Liwen Liang

Transcriptome analysis of HMG family in Salix × Jiangsunesis ‘J795’: characterization, expression patterns and roles in sex differentiation

Pu Wang, Liwen Liang, Jue Zhang, Jie Zhou

The molecular mechanisms underlying sex differentiation in willows remain elusive. To uncover these mechanisms, we performed RNA-Seq on ‘J795’ male, female, and bisexual inflorescences collected from a unique mutant willow that is monoecious but also produces female individuals. The results revealed 7,089 …

cn (code pays fourni par la source)

Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis

Lujun Zhang, Junjiang Fu, Zicheng Hu, Yunli Zhao et autres

Olfactory receptor 6A2 (OR6A2) signaling stimulates atherogenic NLRP3 inflammasome activation in vascular macrophages (Mϕs). Current evidence suggests that interleukin-1 receptor type 1 (IL-1R1)/Toll-like receptor (TLR) signaling may modulate this OR6A2-mediated inflammasome response. However, the role of and mechanism(s) by which IL-1R1/TLR signaling …

cn, us (code pays fourni par la source)

Identifying conservation gaps and proposing climate-smart strategies for amphibians and reptiles on the Qinghai-Tibet Plateau

Lulu Sui, Shun Ma, Shengchao Shi, Xiu-Dong Shi et autres

cn (code pays fourni par la source)

Abstract B130: DUP9, a novel ecteinascidin derivative, as a payload for antibody drug conjugates, exhibits promising preclinical efficacy

Shengchao Lin, Yi Lei, Yu Zhang, Jun Ping Yao et autres

Abstract Introduction: Deruxtecan (DXd)-based antibody drug conjugates (ADCs) have demonstrated remarkable efficacy across a range of cancers in preclinical and clinical studies. However, challenges remain, including intrinsic resistance arises from low or heterogeneous expression of target antigens, or acquired resistance develops after …

Abstract B129: DUP5, a novel mRNA translation inhibitor as a payload for antibody drug conjugates, exhibits promising preclinical efficacy

Shengchao Lin, Bing Li, Yu Zhang, Jun Ping Yao et autres

Abstract Introduction: Currently majority of clinical stage antibody-drug conjugates (ADCs) are based on payloads with either tubulin inhibitors or topoisomerase I inhibitors. There is unmet medical need for ADCs with novel mechanisms of action to treat patients with primary or acquired resistance …

Scutellarin attenuates keloid fibroblast progression by targeting EGFR/PI3K/AKT signaling: An integrated network pharmacology and in vitro experimental study

Zhuohong Li, Liwen Liang, K.K. Li, Bin Yang

cn (code pays fourni par la source)

Electrospray‐based sample preparation for high‐resolution protein structure elucidation by cryo‐EM

Jingjin Fan, Zi Yang, Liwen Liang, Jia Wang et autres

Electrospray-

ru, cn, kr (code pays fourni par la source)

The associations among genetic features, late gadolinium enhancement and prognosis in hypertrophic cardiomyopathy

Wenhua Su, Hao Wu, Chen Chen, Hongjiang Zhang et autres

Aims To assess the combined prognostic value of genotype and late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients, including those with preserved left ventricular ejection fraction (LVEF). Methods In 135 HCM patients (age 52.43 ± 11.35 years, 79.26% male), whole-exome sequencing, …

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Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang et autres

ABSTRACT The healing of diabetic wounds is primarily hindered by persistent inflammation and excessive oxidative stress, increasing the risks of amputation and sepsis. Strategies based on bioactive substances, including recombinant growth factors and histatin proteins (Hsts), have been shown to promote skin‐related …

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Overexpressing OsCCT23 Delays Heading Date and Increases Grain Yield by Activating Ghd7 in Rice

Haijiao Dong, Qingli Wen, Bi Wu, Yutong Yan et autres

Heading date and panicle architecture are pivotal traits that significantly influence rice yield. Here, we identified a gene OsCCT23 encoding a CCT domain-containing protein that delays heading by over 40 days and increases grain yield by 60-104% through overexpressing. Two types transcripts …

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DB-1310, a HER3-targeting antibody-drug conjugate, has synergistic anti-tumor activity with trastuzumab in HER2- and HER3-expressing breast cancer

Xi Li, Liwen Liang, Zhongyuan Zhu, Haiqing Hua et autres

HER3 overexpression has been described in patients with HER2-positive BC[1][1]. We determined the levels of HER2 and HER3 expression in BC using RNA-seq data from 1,082 BC patient samples in the TCGA dataset and 67 BC cell lines in the CCLE database …

cn (code pays fourni par la source)

Effect of Aging Temperature on the Impact Wear Properties and Wear Mechanism of Lightweight Wear-Resistant Steel

Liwen Liang, Jijun Sun, Suotao Wang, Qingfeng Wang

In this study, the microstructure, mechanical properties, wear resistance, and wear-hardening mechanism of Fe-28Mn-8.5Al-1.0C lightweight wear-resistant steel after heat treatment at different aging temperatures were examined. The results show that the nano-scale κ-carbides precipitated in the grains after aging treatment increased the …

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