Qiuyue Yu

Association of TNNI3 and MYBPC3 variants with clinical phenotype and metabolic disorders in patients with hypertrophic cardiomyopathy

H B Wu, Qiuyue Yu, Huimin Li, Z L Yang et autres

INTRODUCTION: Hypertrophic cardiomyopathy is an inherited cardiovascular disease with heterogeneous presentation. However, the metabolic changes resulting from mutations and their relationship to the phenotype remain unclear. OBJECTIVES: To investigate the association between TNNI3 and MYBPC3 variants and both clinical phenotype and metabolic …

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Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale

Nuo Ma, Juan Tao, Qiong Dong, Qiuyue Yu et autres

Background: Enlarged perivascular spaces (EPVS) represent a hallmark imaging feature of cerebral small vessel disease. The ocular vasculature is an anatomical extension of cerebral vessels, constituting part of the microvascular system; however, the relationship between ocular vascular characteristics and EPVS remains poorly …

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The associations among genetic features, late gadolinium enhancement and prognosis in hypertrophic cardiomyopathy

Wenhua Su, Hao Wu, Chen Chen, Hongjiang Zhang et autres

Aims To assess the combined prognostic value of genotype and late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients, including those with preserved left ventricular ejection fraction (LVEF). Methods In 135 HCM patients (age 52.43 ± 11.35 years, 79.26% male), whole-exome sequencing, …

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Enlarged Perivascular Spaces (EPVS) Associated with Functional and Cognitive Outcome After Aneurysm Subarachnoid Hemorrhage (aSAH)

Haichao Wang, Qiuyue Yu, Wenyi Zhang, Shengqi Yao et autres

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MRI-visible enlarged perivascular spaces in basal ganglia rather than centrum semiovale was associated with aneurysmal subarachnoid hemorrhage

Qiuyue Yu, Haichao Wang, Wenyi Zhang, Xiang Zhang et autres

Background: The subarachnoid space is continuous with the perivascular compartment in the central nervous system. However, whether the topography and severity of enlarged perivascular spaces (EPVS) correlates with spontaneous subarachnoid hemorrhage (SAH) remains unknown. Based on the underlying arteriopathy distributions, we hypothesized …

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Neurofilament Light Chain (NF‐L) Stimulates Lipid Peroxidation to Neuronal Membrane through Microglia‐Derived Ferritin Heavy Chain (FTH) Secretion

Li Gong, Qiuyue Yu, Haichao Wang, Chenhaoyi Xu et autres

A part of the axonal cytoskeleton protein complex, neurofilament light chain (NF‐L) has been suggested as a pathological hallmark in various neurological disorders, including hemorrhagic stroke, vascular dementia, and cerebral small vessel disease. Neuroaxonal debris are mainly engulfed and phagocytosed by microglia, …

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Nomogram to Predict Cognitive Dysfunction After a Minor Ischemic Stroke in Hospitalized-Population

Li Gong, Haichao Wang, Xiaofeng Zhu, Qiong Dong et autres

An easily scoring system to predict the risk of cognitive impairment after minor ischemic stroke has not been available. We aimed to develop and externally validate a nomogram for predicting the probability of post-stroke cognitive impairment (PSCI) among hospitalized population with minor …

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Prognostic Factors for Cognitive Recovery Beyond Early Poststroke Cognitive Impairment (PSCI): A Prospective Cohort Study of Spontaneous Intracerebral Hemorrhage

Li Gong, Yongzhe Gu, Qiuyue Yu, Haichao Wang et autres

Background: Post-stroke cognitive impairment (PSCI) has been increasingly recognized in patients, but some stroke survivors appear to show cognitive improvement beyond the acute stage. The risk factors associated with cognitive recovery after spontaneous intracerebral hemorrhage (ICH) onset have not yet been sufficiently …

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