Huimin Li

A systematic transcriptomic atlas and predictive framework for metabolite-driven T cell state transitions

Yiyang Xu, Yiheng Zhao, Sizhe Yang, Huimin Li et autres

Gut microbial and endogenous metabolites are key regulators at the interface of host metabolism and immunity, yet their global effects on human T cell states remain poorly defined. Here, we profile primary human T cell responses to 364 endogenous and microbiota-derived metabolites …

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TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Xinhui Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang et autres

The mandibular condyle is covered by fibrocartilage, and its degeneration, termed temporomandibular joint osteoarthritis (TMJOA), currently lacks effective disease-modifying therapies. In this study, we uncover a previously unrecognized mechanism by which the extracellular matrix protein TGFBI (TGF-β-induced) sustains condylar fibrocartilage homeostasis by …

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Advanced nanocatalytic medicine for genitourinary diseases: Reactive oxygen modulation, precision therapeutics, and clinical translation

Huimin Li, Ye Geng, Lina Wang, Shangxu Jiang et autres

) levels, altered glutathione (GSH) metabolism, mitochondrial dysfunction, and redox imbalance. Biocatalytic nanomaterials, including nanozymes, metallic and metal-oxide nanostructures, single-atom catalysts, hybrid platforms, biomimetic systems, and stimuli-responsive materials, enable context-dependent regulation of reactive oxygen species (ROS). Nanocatalytic platforms exploit these conserved tumor …

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The critical role of ceramide in mental health and psychiatric diseases

Xinran Xu, Huimin Li, Yuncheng Zhu, Xiaoqing Fu et autres

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Association of TNNI3 and MYBPC3 variants with clinical phenotype and metabolic disorders in patients with hypertrophic cardiomyopathy

H B Wu, Qiuyue Yu, Huimin Li, Z L Yang et autres

INTRODUCTION: Hypertrophic cardiomyopathy is an inherited cardiovascular disease with heterogeneous presentation. However, the metabolic changes resulting from mutations and their relationship to the phenotype remain unclear. OBJECTIVES: To investigate the association between TNNI3 and MYBPC3 variants and both clinical phenotype and metabolic …

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng et autres

Mitochondria‑endoplasmic reticulum contact sites (MERCs) are dynamic, nanoscale membrane domains that serve as crucial signaling hubs for inter‑organellar communication. These specialized interfaces are maintained by a complex network composed of tethering, promoter, and disruptor proteins and coordinate a wide range of cellular …

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LINC01234 Coordinates Protein Interactions and ceRNA Networks to Enhance YWHAZ-Driven Malignancy in Triple-Negative Breast Cancer

Diping Yu, Li Chen, Huimin Li, Shiyao Kang et autres

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Dual Regulative Role of Alpha‐Kinase 1 on Synovial Angiogenesis and Chondrocyte Ferroptosis in Inflammatory Osteoarthritis

Xinhui Liu, Xinyue Luo, Jiayi Zhai, Jie Zhao et autres

Alpha-kinase 1 (Alpk1) is identified as a novel pattern recognition receptor with immunomodulatory functions in inflammatory responses. This study investigates the previously unexplored role of Alpk1 in synovial angiogenesis and chondrocyte ferroptosis during osteoarthritis (OA) progression, a degenerative joint disorder currently lacking …

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2-Hydroxyanthraquinone exposure causes the damage of cerebrovascular and blood brain barrier in zebrafish via inducing inflammation and downregulation of the Wnt/β-catenin signaling pathway

Huimin Li, Ziang Wang, S. He, Minghui Zhong et autres

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Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

Juan Yu, Zufeng Zhang, Qingru Yuan, Haobing Hu et autres

Introduction: This study to assess the associations between different rivaroxaban doses and clinical outcomes in elderly NVAF patients in a real-world setting, and to explore factors influencing dose selection. Methods: A retrospective analysis was conducted on elderly patients (aged ≥65 years) diagnosed …

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Single-cell and spatial transcriptomics reveal P4HA2-mediated radiotherapy resistance mechanisms in breast cancer

Huimin Li, Junzhi Liu, Yuheng Jiao, Fengyu Xu et autres

is a potential therapeutic target that sensitizes breast cancer to radiotherapy. The RR gene panel and SSRR model provide insights into resistance mechanisms and prognostic stratification.

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Restricting lipid accumulation in tumor-infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects

Jian Jun Gao, Wei Zhang, Qian Li, Dan Zhao et autres

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