Hao Wu

Hierarchical Precision Nanoplatform for Synergistic Radio‐Immunotherapy in Glioblastoma via Controllable P‐Selectin Targeting

Caiting Meng, Chenyang Qiao, Qian Hao, Jiahong Shi et autres

Abstract The combination of radiotherapy and immune checkpoint blockade (ICB) therapy has demonstrated considerable efficacy in oncological treatment. However, the clinical PD‐L1 antibody (anti‐PD‐L1) for glioblastoma (GBM) imprecisely accumulated in intracranial radiotherapy target and is often compromised by the formidable blood‐brain barrier …

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Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy

Hao Wu, Hongping Li, Li Li, Yung‐Chang Chen et autres

ABSTRACT The dense tumor microenvironment (TME) hinders drug delivery. Herein, we report hyaluronidase/acid/NIR-responsive, size-adaptive nanoparticles (IDHNs) co-loaded with doxorubicin (DOX) and IR780. IDHNs integrate dual targeting with fissile size: biocompatible HSA prolongs circulation, while HA enables CD44-mediated accumulation and hyaluronidase (HAase)-triggered fission …

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MRE-Assessed Hepatic Stiffness Gradient Distinguishes Congestive Hepatopathy from Non-congestive Chronic Liver Disease

Jiahui Li, Peng Xu, Hao Wu, Alina M. Allen et autres

Motivation: Congestion and consequent fibrosis lead to increased liver stiffness in Fontan-associated liver disease (FALD). Stiffness gradient (SG) may distinguish congestive hepatopathy from other chronic liver diseases. Goal(s): To evaluate the repeatability of MRE-assessed hepatic SG and evaluate its ability to differentiate …

Low Expression of Selenoprotein S Modulates Osteogenic Differentiation Through Bidirectional Regulation of the SP7–HSP47/COL1A1/SPARC Axis

Hao Wu, Yunshan Zhao, Chunhao Li, Jingyi Shi et autres

Previous studies revealed that low expression of Selenoprotein S (SELS) could enhance osteogenic differentiation, but the underlying mechanisms remain unclear. In this study, we aimed to elucidate the role of SELS and its transcription-factor-based regulatory mechanism during osteogenic differentiation. In comparison with …

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TyG ‐ BMI index as a valuable risk of acute kidney injury in patients with heart failure: Insights from the MIMIC ‐ IV and eICU cohorts

Yi‐Ming Hua, Ze Chen, Lele Cheng, Ning Ding et autres

BACKGROUND: The triglyceride glucose-body mass index (TyG-BMI) has emerged as a predictor of complications in patients with heart failure (HF). While elevated TyG-BMI levels have been linked to adverse outcomes in HF patients, their predictive value for acute kidney injury (AKI) risk …

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The associations among genetic features, late gadolinium enhancement and prognosis in hypertrophic cardiomyopathy

Wenhua Su, Hao Wu, Chen Chen, Hongjiang Zhang et autres

Aims To assess the combined prognostic value of genotype and late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients, including those with preserved left ventricular ejection fraction (LVEF). Methods In 135 HCM patients (age 52.43 ± 11.35 years, 79.26% male), whole-exome sequencing, …

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Low Expression of Selenoprotein S Promotes Osteogenic Differentiation in Bone Marrow Mesenchymal Stromal Cells

Hao Wu, Jingyi Shi, Yunshan Zhao, Yawen Shi et autres

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Treadmill exercise ameliorates hippocampal synaptic injury and recognition memory deficits by TREM2 in AD rat model

Linlin Zhang, Xin Wang, Hao Wu, Jiahui Xie et autres

The impairment of cognitive function has been associated with Alzheimer’s disease (AD). Exercise exerts a positive modulatory effect on cognition by reducing synapse injury. However, limited in vivo evidence is available to validate the neuroprotective effect of TREM2 on synaptic function in …

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Photoelectrochemical Detection of Alzheimer's Disease Biomarker Using Atomically Dispersed Copper Atoms in Two-Dimensional Porphyrin-Based Metal-Organic Frameworks

Wenting Chen, Chong Cheng, Shuang Li, Hao Wu

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Photoelectrochemical Detection of Alzheimer's Disease Biomarker Using Atomically Dispersed Copper Atoms in Two-Dimensional Porphyrin-Based Metal-Organic Frameworks

Wenting Chen, Chong Cheng, Shuang Li, Hao Wu

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Association of APOE ε4 with cerebrospinal fluid protein and amyloid-β 42 levels in Alzheimer's disease

Fang Yuan, Shuai Liu, Hao Wu, Zhihong Shi et autres

Background Alzheimer's disease (AD) is a neurodegenerative disease, with APOE ε4 as the most common genetic risk factor. This protein has been implicated in amyloid-β peptide (Aβ)-mediated pathological processes in patients with AD. However, the mechanism by which APOE ε4 regulates cerebrospinal …

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Oral Lactoferrin‐Responsive Formulation Anchoring around Inflammatory Bowel Region for IBD Therapy

Jinfan Yang, Ning Shang, Zhengqing Li, Ji Xu et autres

Oral formulation is the ideal treatment method for inflammatory bowel disease (IBD) therapy, but the mucosal damage and diarrhea symptoms impede the drug retention around the inflammatory region, severely limiting IBD therapeutic efficacy. To address this, an oral astaxanthin (Ast) precise delivery …

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