Accès ouvert
2025
article
OpenAlex
Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV, Inaam Sado et autres
During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting neonatal energy demands. Shortly after birth, lipogenesis begins, driven by transcriptional activation of enzymes …
de, au, fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Aurora Bernal, Arslan Hamid, Cristina Grao-Roldán, Alice Scarpa et autres
ABSTRACT Background and aims Lipids play a critical role in atherosclerosis. Low-density lipoprotein (LDL)-cholesterol and certain lipid classes like sphingomyelins are associated with inflammation and poor cardiovascular outcomes. Phosphatidylserine (PS), on the other hand, is a negatively charged anti-inflammatory phospholipid class involved …
cu, de, es, us, nl
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Alina Schieren, Hanna Huber, Carolina Alvarez-Garavito, Aakash Mantri et autres
Metabolic responses to dietary interventions often show high inter-individual variations, but the factors explaining these variations as well as underlying mechanisms and their interrelation remain largely unknown. Knowing which factors are relevant for the individual response to a dietary intervention and to …
de, nl, dk
(code pays fourni par la source)
2025
preprint
OpenAlex
Hanna Huber, Alina Schieren, A.C.D. Donkers, Aakash Mantri et autres
ABSTRACT Background Beneficial effects of diets with predominance of plant-based foods as fruits, vegetables, whole grain and plant-protein and less animal-based foods, or so-called “ plant-based ” diets, on cardiometabolic risk have been reported. We aimed to examine the effects of two …
de, dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yanxia Liu, Sandra Theil, Mohamed H. Yaghmour, Anja Kerksiek et autres
Retention in endoplasmic reticulum sorting receptor 1 (RER1) mediates the retention and retrieval of select cargo proteins, and thereby regulates protein transport in the secretory pathway and assembly of distinct protein complexes. Recently, RER1 was implicated in the assembly and subcellular transport …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hao Huang, Nora Reka Balzer, Lea Seep, Iva Šplíchalová et autres
Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1–3. Throughout development and adulthood, KCs perform distinct core functions …
de, at, se, be, cn, sg, fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Nicole Kucharowski, Diana Ramos, Hannah Soyka, Klaus Wunderling et autres
Abstract Insulin is a peptide hormone that is secreted in Golgi-derived dense-core vesicles from mammalian pancreatic beta-cells in response to nutrients. In Drosophila melanogaster , three insulin-like peptides are secreted as neuropeptides from the insulin-producing cells in the brain. Peroxisomes are lipid-metabolizing …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mohamed H. Yaghmour, Theja Sajeevan, Christoph Thiele, Lars Kuerschner
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain composition. This batch is constantly remodeled by the Lands cycle, a metabolic pathway replacing one chain at a time. Using the alkyne …
de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV, Inaam Sado et autres
Abstract During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting the energy demands of the neonate. Shortly after birth, lipogenesis begins, driven by …
de, au
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Mohamed H. Yaghmour, Christoph Thiele, Lars Kuerschner
Phospholipids with a choline head group are an abundant component of cellular membranes and are involved in many important biological functions. For studies on the cell biology and metabolism of these lipids, traceable analogues where propargylcholine replaces the choline head group have …
de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Klaus Wunderling, Christina Leopold, Isabell Jamitzky, Mohamed H. Yaghmour et autres
OBJECTIVE: Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG), and the rest is used for oxidative energy production or ketogenesis. We investigated which enzymes catalyse the …
de, at
(code pays fourni par la source)