Accès ouvert
2023
article
OpenAlex
Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking et autres
Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases in the cytosol, the N-terminal domain of GSDMD forms …
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Accès ouvert
2023
preprint
OpenAlex
Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking et autres
Abstract Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases, the N-terminal domain of GSDMD forms pores in the …
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(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Marie Paradis, Nicole Kucharowski, Gabriela Edwards‐Faret, Santiago José Maya Palacios et autres
Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson’s disease, which is also characterized by impaired complex …
de, be
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Marie Paradis, Nicole Kucharowski, Gabriela Edwards, Santiago Maya Palacios et autres
de, us
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Accès ouvert
2020
article
OpenAlex
Klaus Wunderling, Christina Leopold, Isabell Jamitzky, Mohamed H. Yaghmour et autres
OBJECTIVE: Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG), and the rest is used for oxidative energy production or ketogenesis. We investigated which enzymes catalyse the …
de, at
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