Iva Šplíchalová

Kupffer cell programming by maternal obesity triggers fatty liver disease

Hao Huang, Nora Reka Balzer, Lea Seep, Iva Šplíchalová et autres

Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1–3. Throughout development and adulthood, KCs perform distinct core functions …

de, at, se, be, cn, sg, fr (code pays fourni par la source)

From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists

Lea Seep, Stephan Grein, Iva Šplíchalová, Danli Ran et autres

Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. However, relevant information resides at differing stages across the data-lifecycle. Often, this information is defined and …

de, us (code pays fourni par la source)

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

During embryogenesis, the fetal liver becomes the main hematopoietic organ, where stem and progenitor cells as well as immature and mature immune cells form an intricate cellular network. Hematopoietic stem cells (HSCs) reside in a specialized niche, which is essential for their …

de, us (code pays fourni par la source)

Author response: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.

de, us (code pays fourni par la source)

From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists

Lea Seep, Stephan Grein, Iva Šplíchalová, Danli Ran et autres

ABSTRACT Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. However, relevant information resides at differing stages across the data-lifecycle. Often, this information is defined …

de, cz, us (code pays fourni par la source)

Correction: Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover

Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová et autres

us (code pays fourni par la source)

Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover

Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová et autres

Intestinal epithelial cells have the capacity to upregulate MHCII molecules in response to certain epithelial-adhesive microbes, such as segmented filamentous bacteria (SFB). However, the mechanism regulating MHCII expression as well as the impact of epithelial MHCII-mediated antigen presentation on T cell responses …

cz, il (code pays fourni par la source)

Fate-Mapping of Yolk Sac-Derived Macrophages

Iva Šplíchalová, Elvira Mass

de (code pays fourni par la source)

Developmental programming of Kupffer cells by maternal obesity causes fatty liver disease in the offspring

Hao Huang, Iva Šplíchalová, Nora Reka Balzer, Lea Seep et autres

de, cz, cn, hr, sg, fr (code pays fourni par la source)

P1332: ALL EMBRYONIC HEMATOPOIETIC WAVES EMERGE FROM HEMATO-ENDOTHELIAL PROGENITORS

Michaela Šímová, Carlos Eduardo Madureira Trufen, Iva Šplíchalová, Jan Kubovčiak et autres

Topic: 23. Hematopoiesis, stem cells and microenvironment Background: The emergence of blood cells during mammalian embryonic development occurs in three independent waves of different origin. Importantly, the first blood cells emerge in the extra embryonic Yolk-sac (YS). The YS provides the embryo …

cz (code pays fourni par la source)

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

Amir Hossein Kayvanjoo, Iva Šplíchalová, David Alejandro Bejarano, Hao Huang et autres

Abstract During embryogenesis, the fetal liver becomes the main hematopoietic organ, where stem and progenitor cells as well as immature and mature immune cells form an intricate cellular network. Hematopoietic stem cells (HSCs) reside in a specialized niche, which is essential for …

de, us (code pays fourni par la source)

IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

Tomáš Brabec, Matouš Vobořil, Dagmar Schierová, Evgeny Valter et autres

Interleukin (IL)-17 protects epithelial barriers by inducing the secretion of antimicrobial peptides. However, the effect of IL-17 on Paneth cells (PCs), the major producers of antimicrobial peptides in the small intestine, is unclear. Here, we show that the targeted ablation of the …

cz, ru, us, de (code pays fourni par la source)