Anita Siller

Adaptation of the Yield-Scaling Factor to Reduce Target Yield Deviation and Donation Time in Pathogen-Reduced Apheresis Platelet Collections Using the Sysmex XN1000 Blood Bank Mode

Marco Amato, Anita Siller, Lisa Seekircher, Manfred Astl et autres

Background: Platelet concentrates from apheresis donations are indispensable in transfusion medicine. Integration of pathogen reduction (PR) technologies into platelet manufacturing requires adjustment of apheresis devices to ensure consistent platelet yields while minimizing donation time. We investigated the suitability of Sysmex XN1000 (Sysmex …

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Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth et autres

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from pro-inflammatory toward anti-inflammatory and pro-resolving mediators. …

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Leaf senescence reshapes phytochemistry and bioactivity in Carica papaya: Implications for the traditional use of aged leaf extracts

Christian A. Elvert, Sven Nicolay, Elif N. Cömen, Zhigang Rao et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Leaf preparations of Carica papaya L. (Caricaceae) are widely used in traditional medicine across Africa, Asia, the Caribbean, and Australia for the management of inflammatory conditions, dengue fever, asthma, infections, wound healing, and, in some traditions, cancer. Ethnopharmacological reports further …

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Tocotrienol metabolites redirect lipid mediator production in innate immune cells towards inflammation resolution

Stephan Permann, Elena Brunner, Khaled Alsabil, Markus Werner et autres

Restoring homeostasis in persistent inflammation requires suppressing the inflammatory response and promoting resolution. Currently, no clinically used small molecules intentionally achieve both effects. Endogenous long-chain vitamin E metabolites (LCMs) address inflammation at multiple sites, including pro-inflammatory leukotriene production and cytokine release, thus …

Regional and demographic patterns of seroprevalence of Borrelia burgdorferi IgG and IgM antibodies in blood donors in Austria

Mateusz Markowicz, Andreas Wolfsbauer, Christof Jungbauer, Patrick Paul Torreiter et autres

Knowledge about the epidemiology of Lyme borreliosis in Austria remains limited. We conducted a nationwide cross-sectional study among blood donors from all Austrian provinces to assess the exposure to Borrelia burgorferi sensu lato. A total of 1841 serum samples from blood donors …

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Seroprevalence of IgM and IgG Antibodies Directed Against Hepatitis E Virus in 4867 Blood Donors From Tyrol, Austria

Lisa Seekircher, A. Mühlbacher, Lena Tschiderer, Marco Amato et autres

There may be a risk of transmitting Hepatitis E Virus (HEV) through blood transfusions, however screening blood donors for HEV is not mandatory in Austria. We assessed the seroprevalence of anti-HEV antibodies among blood donors, thereby informing about the risk of HEV-contaminated …

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Virtual reality for pain and anxiety reduction during venous puncture procedures

Andreas Rosenecker, Marco Amato, Isabel Geiger, Simon Winkler et autres

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Context-dependent Activities of Mitrephorone Link Lipid Redirection, Anti-inflammatory Action, and Ferroptosis Control to Hepatocyte Protection

Lorenz Waltl, Lukas A. Wein, Leonhard Bereuter, Fengting Su et autres

Rationale: . Methods: disease models. Quantitative lipidomics, cell viability and membrane integrity assays, overexpression studies, immunodetection, molecular probes, expression analysis, and cell-free activity assays were used to assess effects on programmed cell death, lipid mediator biosynthesis, cytokine expression, and alternations of the …

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Serum Eye Drops: Implementation, Upscaling, and Patient-Centered Care – Insights from a Blood Bank in Western Austria

Anita Siller, Harald Schennach, Marco Amato

Background: Serum eye drops (SEDs) have emerged as an important therapeutic option for the management of severe ocular surface diseases, particularly in cases refractory to conventional treatments. Despite their proven efficacy, the implementation and expansion of SED therapy in clinical practice present …

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A Validated Method for the Simultaneous Measurement of Tryptophan, Kynurenine, Phenylalanine, and Tyrosine by High-Performance Liquid Chromatography–Ultraviolet/Fluorescence Detection in Human Plasma and Serum

Lucia Parráková, Cornelia A. Karg, S Hofer, Pablo Monfort‐Lanzas et autres

High Resolution Image Download MS PowerPoint Slide Aromatic amino acids are precursors of neurotransmitters and immunomodulatory molecules, and their catabolism is dysregulated in various disorders associated with inflammation. This dysregulation often correlates with disease stage, symptom severity, comorbidities, quality of life, and …

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Francisella tularensis surveillance - infection-induced seroprevalences in Western Austria 2025

Anita Siller, Lidia Chitimia‐Dobler, Fabian Wilhelm, Marco Amato et autres

Background: Notified tularemia cases have been increasing in both the European Union and Austria, yet no contemporary seroprevalence data are available. This study aimed to estimate the current tularemia seroprevalence in Western Austria and to inform prevention programs by comparing seroprevalence-derived incidence …

Babesiosis and Its Significance in Transfusion Medicine from a European Point of View

Marco Amato, Anita Siller, Harald Schennach

Background: Babesiosis, caused by intraerythrocytic parasites of the genus Babesia, represents an emerging global health threat due to its capacity for persistent infection and transfusion transmission. The ability of Babesia spp. to establish chronic, asymptomatic infections lasting up to 2 years in …

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