Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth et autres
Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from pro-inflammatory toward anti-inflammatory and pro-resolving mediators. …
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Advanced Science