Seroprevalence of IgM and IgG Antibodies Directed Against Hepatitis E Virus in 4867 Blood Donors From Tyrol, Austria
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Le résumé fourni par la source
There may be a risk of transmitting Hepatitis E Virus (HEV) through blood transfusions, however screening blood donors for HEV is not mandatory in Austria. We assessed the seroprevalence of anti-HEV antibodies among blood donors, thereby informing about the risk of HEV-contaminated blood products. Between May and July 2022, we enrolled 4867 blood donors aged 18-70 years at 38 donation events spread across the Federal State of Tyrol, Austria. We measured anti-HEV IgG and IgM antibodies using five validated assays, based on which overall anti-HEV seropositivity was defined. We determined seroprevalences with 95% confidence intervals (CI) and calculated odds ratios for seropositivity using logistic regression. Median age of participants was 45.99 years (25th-75th percentile: 31.49-55.80); 41.15% were female, and 75.82% lived in rural areas. Anti-HEV IgM was detected in 13 individuals, i.e. 0.27% (95% CI: 0.16-0.47%). Anti-HEV IgG seroprevalence was 19.26% (18.17-20.40%) overall. It was higher in older blood donors - peaking in the 65-70-year age group (47.92%) -, higher in males (20.70%) than females (17.20%) and higher in urban (21.28%) compared to rural areas (18.61%). Multivariable adjusted odds ratios for IgG seropositivity were 1.19 for male sex (1.01-1.39; p = 0.033), 2.15 per 10-year older age (2.00-2.30; p < 0.001) and 1.21 for residing in an urban area (1.02-1.45; p = 0.030). Our findings indicate that HEV is widespread in Austria. Implementation of mandatory routine HEV nucleic acid testing should be considered in blood donations to enhance transfusion safety.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Seroprevalence of IgM and IgG Antibodies Directed Against Hepatitis E Virus in 4867 Blood Donors From Tyrol, Austria
- Date Crossref
- 29/05/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Innsbruck Medical University pays non établi dans la noticeUniversité ou école supérieure
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Universität Innsbruck pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Innsbruck pays non établi dans la noticeÉtablissement de santé
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University of Cambridge pays non établi dans la noticeUniversité ou école supérieure
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Medical Statistics and Informatics Medical University of Innsbruck Innsbruck Austria Institute of Clinical Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Ignaz Semmelweis Institute Interuniversity Institute for Infection Research Vienna Austria pays non établi dans la noticeUniversité ou école supérieure
Innsbruck Medical University, Universität Innsbruck et University Hospital Innsbruck, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.