Klaus Speck

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth et autres

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from pro-inflammatory toward anti-inflammatory and pro-resolving mediators. …

at, it (code pays fourni par la source)

CCDC 1920377: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1921469: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1921468: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1921470: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1921471: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1920379: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1920381: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1921467: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1920378: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

CCDC 1920380: Experimental Crystal Structure Determination

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

Synthetic Entry to Polyfunctionalized Molecules through the [3+2]-Cycloaddition of Thiocarbonyl Ylides

Franz‐Lucas Haut, Christoph Habiger, Klaus Speck, Klaus Wurst et autres

Abstract Here we present a comprehensive study on the [3+2]-cycloaddition of thiocarbonyl ylides with a wide variety of alkenes and alkynes. The obtained dihydro- and tetrahydrothiophene products serve as exceptionally versatile intermediates providing access to thiophenes, dienes, dendralenes, and vic-quarternary carbon centers. …

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