Sven Nicolay

Leaf senescence reshapes phytochemistry and bioactivity in Carica papaya: Implications for the traditional use of aged leaf extracts

Christian A. Elvert, Sven Nicolay, Elif N. Cömen, Zhigang Rao et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Leaf preparations of Carica papaya L. (Caricaceae) are widely used in traditional medicine across Africa, Asia, the Caribbean, and Australia for the management of inflammatory conditions, dengue fever, asthma, infections, wound healing, and, in some traditions, cancer. Ethnopharmacological reports further …

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The power of combining MS and NMR in biochemometrics: Identification of bioactives from Buddleja officinalis Maxim. flowers

Andreas Wasilewicz, Alexander Areesanan, Benjamin Kirchweger, Sven Nicolay et autres

The biological testing of natural extracts containing hundreds of constituents has always been a prolific yet challenging approach to identify bioactive natural compounds. In recent years, sophisticated biochemometric tools have emerged as strategy to unravel bioactive constituents from multi-component mixtures. This computer-assisted …

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Potential benefits of Malva sylvestris in treating dry-eye pathology in vitro

Alexander Areesanan, Sven Nicolay, Morris Keller, Amy Marisa Zimmermann-Klemd et autres

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Immunomodulatory Effects of Copper Bis-Glycinate In Vitro

Alexander Areesanan, Sven Nicolay, Amy Marisa Zimmermann-Klemd, Carsten Gründemann

Copper functions as a cofactor and antioxidants in a large number of enzymes that are important for cellular respiration and the nervous system. In the last century scholars have explored copper’s relationship with the immune system, with copper deficiency drastically upsetting the …

ch (code pays fourni par la source)

Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease

Alexander Areesanan, Andreas Wasilewicz, Sven Nicolay, Ulrike Grienke et autres

Introduction Ethnic groups worldwide use mushrooms, particularly polypores (a group of fungi with woody fruiting bodies), to manage inflammatory conditions. In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies of Fomes …

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Pharmacological in vitro profiling of Buddleja officinalis flower extracts in the context of dry eye disease

Alexander Areesanan, Andreas Wasilewicz, Benjamin Kirchweger, Sven Nicolay et autres

BACKGROUND: Dry eye disease (DED) is caused by inflammation on the ocular surface and insufficient quality or production of the tear film. Due to various harmful environmental conditions, a gradual increase of DED cases has been reported. HYPOTHESIS/PURPOSE: This study aims for …

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Combining the Strengths of MS and NMR in Biochemometrics: A Case Study on Buddleja officinalis

Andreas Wasilewicz, Alexander Areesanan, Benjamin Kirchweger, Sven Nicolay et autres

High Resolution Image Download MS PowerPoint Slide Biochemometrics has emerged as promising strategy for the targeted identification of bioactive constituents from natural sources. It is based on the correlation of bioactivity data with chemical data to reveal constituents contributing to activity. Providing …

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Impact of Fermentation on the Phytochemical Profile and Bioactivity Characteristics of Aqueous Matricaria recutita L. Root Extracts

Lilo K. Mailänder, Khadijeh Nosrati Gazafroudi, Marit Greiß, Peter Lorenz et autres

Abstract While the flowers of Matricaria recutita L., German chamomile, are widely used for medicinal and cosmetic purposes, little is known about its roots, which are used in complementary medicine for the preparation of aqueous fermented extracts for the treatment of cramps …

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Potential benefits of Malva sylvestris in dry-eye disease pathology in vitro based on antioxidant, wound-healing and anti-inflammatory properties

Alexander Areesanan, Sven Nicolay, Morris Keller, Amy Marisa Zimmermann-Klemd et autres

Dry eye disease (DED) is a common chronic ocular surface disease. Available therapies are effective but often associated with side effects. This study investigates the potential of a Malva sylvestris L. flower extract and two defined preparations, a mucilage and a polyphenol …

ch (code pays fourni par la source)

Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations

Bernhard Retzl, Amy Marisa Zimmermann-Klemd, Carsten Gründemann, Christian W. Gruber et autres

Abstract Viola tricolor is a medicinal plant with documented application as an anti-inflammatory herb. The standard of care for the treatment of inflammatory bowel disease is immunosuppressive therapeutics or biologics, which often have undesired effects. We explored V. tricolor herbal preparations that …

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Comparison of Aqueous and Lactobacterial-Fermented Mercurialis perennis L. (Dog’s Mercury) Extracts with Respect to Their Immunostimulating Activity

Peter Lorenz, Ilona Zilkowski, Lilo K. Mailänder, Iris Klaiber et autres

Lactic acid (LA) fermentation of dog’s mercury (M. perennis L.) herbal parts was investigated in samples inoculated with either Lactobacteria (Lactobacillus plantarum and Pediococcus pentosaceus, LBF) or whey (WF). Depending on fermentation time, LA concentrations were monitored in a range of 3.4–15.6 …

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Bi-allelic expression of the RyR1 p.A4329D mutation decreases muscle strength in slow-twitch muscles in mice

Moran Elbaz, Alexis Ruiz, Sven Nicolay, Chiara Tupini et autres

Mutations in the ryanodine receptor 1 ( RYR1 ) gene are associated with several human congenital myopathies, including the dominantly inherited central core disease and exercise-induced rhabdomyolysis, and the more severe recessive phenotypes, including multiminicore disease, centronuclear myopathy, and congenital fiber type …

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