Claudia A. Costa

Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

Carina Colturato-Kido, Rayssa de Mello Lopes, Hyllana C. D. Medeiros, Claudia A. Costa et autres

Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the development of new therapeutic strategies and drugs to …

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Targeting mitochondria in melanoma: Interplay between MAPK signaling pathway and mitochondrial dynamics

Letícia Silva Ferraz, Renata Torres da Costa, Claudia A. Costa, César Augusto João Ribeiro et autres

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BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors

Gabriela Nohemi Nuñez Esteves, Letícia Silva Ferraz, Marcela Maciel Palacio Alvarez, Claudia A. Costa et autres

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Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential

Claudia A. Costa, Rayssa de Mello Lopes, Letícia Silva Ferraz, Gabriela Nohemi Nuñez Esteves et autres

Chemical modifications of quinoline moiety have been recognized as a useful strategy to development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted quinolines (named HTI) was screened for their antitumor and antileishmanial potential in vitro, and the underlying …

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Nanostructured Hematite Decorated with Gold Nanoparticles for Functionalization and Biocompatibility

Lucivaldo R. Menezes, Guilherme Sombrio, Claudia A. Costa, Julia D. Bronzato et autres

Biocompatibility Hematite nanowires grown on the surface of microtubes are decorated with gold nanoparticles produced in situ by the use of the reducing capacity of the semiconductor on gold ions. Gold nanoparticles allow functionalization with thiolic compounds and improve the biocompatibility of …

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Nanostructured Hematite Decorated with Gold Nanoparticles for Functionalization and Biocompatibility

Lucivaldo R. Menezes, Guilherme Sombrio, Claudia A. Costa, Julia D. Bronzato et autres

Iron oxides have attracted the attention of researchers due to their abundance, low cost, low toxicity, and versatility of applications. According to the composition and crystalline structure, iron oxides may have characteristics of semiconductors and magnetic materials, such as hematite (α‐Fe2O3) and …

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AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia

Hyllana C. D. Medeiros, Carina Colturato-Kido, Letícia Silva Ferraz, Claudia A. Costa et autres

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Next generation sequencing: a golden tool in mitochondrial diseases

Célia Nogueira, Cristina Pereira, Lisbeth Sousa Silva, Elisa Leão Teles et autres

The development of Next Generation Sequencing (NGS) has revolutionized the diagnostic approach of mitochondrial disorders, particularly in children. The purpose of our project is to develop a NGS strategy to identify the genetic defect in 250 patients, to confirm the clinical diagnosis …

Analysis in silico of phospholipase A1 sequences (PLA 1) in the order Hymenoptera

Alicia Arica, Claudia A. Costa, Roberto Pineda

Hymenoptera possess poisons that are a mixture of different substances. Among them we find vasoactive amines, peptides and proteins, mostly enzymes such as phospholipases. Phospholipase A1 is one that cleaves the ester bond between the first acyl and glycerol, hydrolyzing the phospholipids …

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Next Generation Sequencing Improves Mitochondrial Diseases Diagnosis

Célia Nogueira, Laura Vilarinho, Cristina Pereira, Lisbeth Sousa Silva et autres

Objectives: The overall aim of our research project was to develop a Next Generation Sequencing strategy to identify nuclear disease causing-mutations in patients suspicious of mitochondrial disorders but without molecular etiology.

Mitochondrial disorders: insights into diagnosis and management in the new era of genomic medicine

Célia Nogueira, Laura Vilarinho, Cristina Pereira, Lisbeth Sousa Silva et autres

Objectives: The overall aim of our research project was to develop a Next Generation Sequencing strategy to identify nuclear disease causing-mutations in patients suspicious of mitochondrial disorders but without molecular etiology.

Evaluation of isoflavone content and cytotoxic activity of two new mexican alfalfa-based foodstuffs

Maria Guadalupe Soto-Zarazúa, Francisca América Fernandes Rodrigues, Claudia A. Costa, Filipa B. Pimentel et autres

Alfalfa (Medicago sativa) has been used as traditional medicine for the treatment of some diseases, being a source of phytoestrogens (mainly isoflavones), with beneficial properties for humans. Furthermore, this plant is widely consumed, either directly ingested as a fresh food or as …