Hyllana C. D. Medeiros

Cystine-Dependent Redox Metabolism Determines Photodynamic Therapy Response in Head and Neck Squamous Cell Carcinoma

Amir Roshanzadeh, Hyllana C. D. Medeiros, Tessa Jordan, Carson Malhado et autres

Abstract Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat without substantial functional and cosmetic morbidity, as current management relies largely on surgery, radiation, and chemotherapy. However, these approaches often fail to achieve effective tumor control in therapy-resistant HNSCC. Photodynamic …

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Next‐Generation Photosensitizers: Cyanine‐Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer

Amir Roshanzadeh, Hyllana C. D. Medeiros, Christopher K. Herrera, Carson Malhado et autres

Abstract Photodynamic therapy (PDT) has emerged as a promising targeted treatment for cancer. However, current PDT is limited by low tissue penetration, insufficient phototoxicity (toxicity with light irradiation), and undesirable cytotoxicity (toxicity without light irradiation). Here, we report the discovery of cyanine‐carborane …

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Next‐Generation Photosensitizers: Cyanine‐Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer

Amir Roshanzadeh, Hyllana C. D. Medeiros, Christopher K. Herrera, Carson Malhado et autres

Abstract Photodynamic therapy (PDT) has emerged as a promising targeted treatment for cancer. However, current PDT is limited by low tissue penetration, insufficient phototoxicity (toxicity with light irradiation), and undesirable cytotoxicity (toxicity without light irradiation). Here, we report the discovery of cyanine‐carborane …

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The liver converts fructose into lipids to fuel tumours

Hyllana C. D. Medeiros, Sophia Y. Lunt

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Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

Elliot Ensink, Tessa Jordan, Hyllana C. D. Medeiros, Galloway Thurston et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high mortality and limited efficacious therapeutic options. PDAC cells undergo metabolic alterations to survive within a nutrient-depleted tumor microenvironment. One critical metabolic shift in PDAC cells occurs through altered isoform expression of …

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Adipocyte-derived kynurenine stimulates malignant transformation of mammary epithelial cells through the aryl hydrocarbon receptor

Jonathan D. Diedrich, Romina Gonzalez-Pons, Hyllana C. D. Medeiros, Elliot Ensink et autres

Anti-hormone therapies are not efficacious for reducing the incidence of triple negative breast cancer (TNBC), which lacks both estrogen and progesterone receptors. While the etiology of this aggressive breast cancer subtype is unclear, visceral obesity is a strong risk factor for both …

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Adipocyte-Derived Kynurenine Stimulates Malignant Transformation of Mammary Epithelial Cells Through the Aryl Hydrocarbon Receptor

Jonathan D. Diedrich, Romina Gonzalez-Pons, Hyllana C. D. Medeiros, Elliot Ensink et autres

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Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis Through Malic Enzyme 1 in Pancreatic Cancer Cells

Elliot Ensink, Tessa Jordan, Hyllana C. D. Medeiros, Galloway Thurston et autres

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Counterion Tuning of Near-Infrared Organic Salts Dictates Phototoxicity to Inhibit Tumor Growth

Deanna Broadwater, Hyllana C. D. Medeiros, Matthew Bates, Amir Roshanzadeh et autres

High Resolution Image Download MS PowerPoint Slide Photodynamic therapy (PDT) has the potential to improve cancer treatment by providing dual selectivity through the use of both photoactive agent and light, with the goal of minimal harmful effects from either the agent or …

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Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy

Hyllana C. D. Medeiros, Chenchen Yang, Christopher K. Herrera, Deanna Broadwater et autres

Photodynamic therapy (PDT) is currently limited by the inability of photosensitizers (PSs) to enter cancer cells and generate sufficient reactive oxygen species. Utilizing phosphorescent triplet states of novel PSs to generate singlet oxygen offers exciting possibilities for PDT. Here, we report phosphorescent …

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The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation

Hyllana C. D. Medeiros, Sophia Y. Lunt

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Current Advances in Photoactive Agents for Cancer Imaging and Therapy

Deanna Broadwater, Hyllana C. D. Medeiros, Richard R. Lunt, Sophia Y. Lunt

Photoactive agents are promising complements for both early diagnosis and targeted treatment of cancer. The dual combination of diagnostics and therapeutics is known as theranostics. Photoactive theranostic agents are activated by a specific wavelength of light and emit another wavelength, which can …

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