Rayssa de Mello Lopes

Natural metabolites from Tabebuia aurea reveal isoform-specific and cooperative modulation of cathepsins B and L

Marli de Fátima Corrêa Emiliano, Mariele Rondon Santos Gonçalves, Leice Milla Ribeiro de Novais, Marcos J. Jacinto et autres

= 12.47 μM) while sparing non-tumor HaCaT cells. Molecular docking and molecular dynamics simulations of 1:1 complexes provided structural context for the observed isoform-specific binding modes. These results demonstrate that structurally simple phenolic compounds can induce fundamentally different inhibition mechanisms in closely …

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PRECLINICAL EVALUATION OF QONA11, A NOVEL QUINAZOLINONE, IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA

Gilberto Carlos Franchi, Giorgio Antoniolli, CSP Lima, Keli Lima et autres

This work describes the evaluation of the novel derivative Qona11 (2-substituted quinazolin-4(3H) -one), synthesised via the condensation of 2-aminobenzamide and 1H-benzo[d]imidazole-2-carbaldehyde, with its structure confirmed by IR and ¹H/¹³C NMR spectroscopy. In silico characterisation predicted a favourable pharmacokinetic profile with high intestinal …

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In Silico, in vitro, and in vivo studies of a 2-substituted quinazolin-4(3H)-one in T-cell acute lymphoblastic leukemia

Giorgio Antoniolli, Gilberto C. Franchi, Keli Lima, Rayssa de Mello Lopes et autres

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Targeting autophagy by antipsychotic phenothiazines: potential drug repurposing for cancer therapy

Rayssa de Mello Lopes, Ana Carolina Santos de Souza, Michał Otręba, Anna Rzepecka‐Stojko et autres

Cancer is recognized as the major cause of death worldwide and the most challenging public health issues. Tumor cells exhibit molecular adaptations and metabolic reprograming to sustain their high proliferative rate and autophagy plays a pivotal role to supply the high demand …

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Astaxanthin induces autophagy and apoptosis in murine melanoma B16F10-Nex2 cells and exhibits antitumor activity in vivo

Fernanda Fernandes Miranda da Cunha, Ângela Pedroso Tonon, Fabricio Castro Machado, Luis Rodolpho Travassos et autres

Countless efforts have been made to prevent and suppress the formation and spread of melanoma. Natural astaxanthin (AST; extracted from the alga Haematococcus pluvialis) showed an antitumor effect on various cancer cell lines due to its interaction with the cell membrane. This …

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Rosemary (Rosmarinus officinalis L.) Glycolic Extract Protects Liver Mitochondria from Oxidative Damage and Prevents Acetaminophen-Induced Hepatotoxicity

Natalia Sernizon Guimarães, Vyctória S. Ramos, Laura Francisca Leite do Prado-Souza, Rayssa de Mello Lopes et autres

Rosmarinus officinalis L. (rosemary) is an aromatic culinary herb. Native to the Mediterranean region, it is currently cultivated worldwide. In addition to its use as a condiment in food preparation and in teas, rosemary has been widely employed in folk medicine and …

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O papel da autofagia sobre a morte celular induzida por fenotiazina em células de leucemia

Rayssa de Mello Lopes

Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior

Targeting Ca2+ and Mitochondrial Homeostasis by Antipsychotic Thioridazine in Leukemia Cells

Vivian Moraes, Vivian M. Santos, Eloah Rabello Suarez, Letícia Silva Ferraz et autres

Mitochondria have pivotal roles in cellular physiology including energy metabolism, reactive oxygen species production, Ca2+ homeostasis, and apoptosis. Altered mitochondrial morphology and function is a common feature of cancer cells and the regulation of mitochondrial homeostasis has been identified as a key …

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Cysteine proteases as potential targets for anti-trypanosomatid drug discovery

Wagner Alves de Souza Júdice, Letícia Silva Ferraz, Rayssa de Mello Lopes, Luan dos Santos Vianna et autres

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Inhibition of Autophagy Enhances the Antitumor Effect of Thioridazine in Acute Lymphoblastic Leukemia Cells

Carina Colturato-Kido, Rayssa de Mello Lopes, Hyllana C. D. Medeiros, Claudia A. Costa et autres

Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells that affects children and adults. Despite the high cure rates, drug resistance still remains a significant clinical problem, which stimulates the development of new therapeutic strategies and drugs to …

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BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors

Gabriela Nohemi Nuñez Esteves, Letícia Silva Ferraz, Marcela Maciel Palacio Alvarez, Claudia A. Costa et autres

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Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential

Claudia A. Costa, Rayssa de Mello Lopes, Letícia Silva Ferraz, Gabriela Nohemi Nuñez Esteves et autres

Chemical modifications of quinoline moiety have been recognized as a useful strategy to development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted quinolines (named HTI) was screened for their antitumor and antileishmanial potential in vitro, and the underlying …

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