Wagner Alves de Souza Júdice

Natural metabolites from Tabebuia aurea reveal isoform-specific and cooperative modulation of cathepsins B and L

Marli de Fátima Corrêa Emiliano, Mariele Rondon Santos Gonçalves, Leice Milla Ribeiro de Novais, Marcos J. Jacinto et autres

= 12.47 μM) while sparing non-tumor HaCaT cells. Molecular docking and molecular dynamics simulations of 1:1 complexes provided structural context for the observed isoform-specific binding modes. These results demonstrate that structurally simple phenolic compounds can induce fundamentally different inhibition mechanisms in closely …

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Critical role of Asp283 in modulating calcium-dependent autoprocessing of yeast Metacaspase ScMCA-Ia

Mariana Nascimento Romero Trujilho, Laura de Azevedo Maffeis Dalzoto, Taiz dos Reis Santos, Ane Caroline Moreira Duarte et autres

Metacaspases are Ca 2+ -dependent cysteine proteases essential for programmed cell death. This study elucidates the regulatory mechanisms of Saccharomyces cerevisiae type I metacaspase (ScMCA-IA), focusing on Ca 2+ -dependent autoprocessing and the function of its N-terminal hydrophobic prodomain. Through cloning, heterologous …

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Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ANA CAROLINA ROCHA BARRETO, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição et autres

Chagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi) , remains a major public health challenge due to the limited efficacy and high toxicity of current treatments. In this study, we describe the design and synthesis of 10 imidazo[1,2‐a]pyridine derivatives as …

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Imine-metal complexes showing remarkable antiparasitic activity against Trypanosoma cruzi: different modes of action modulated by the ligand and the metal ion

Marcelo Cecconi Portes, Luan dos Santos Vianna, Maria Luiza Gonçalves Gallego Rosa, Silvana Ribeiro et autres

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Chalcones and flavonoids: New perspectives in the modulation of Trypanosoma brucei metacaspase-2

Laura Helena Araujo, Mariana Nascimento Romero Trujilho, Estela Mariana Guimarães Lourenço, Ane Caroline Moreira Duarte et autres

values. Mechanistic studies identified competitive inhibition for EM-1A, EM-1C, and EM-F12C, while EM-1B exhibited non-competitive inhibition. These findings demonstrate chalcone and flavonoid derivatives as potential anti-AHT agents, effectively inhibiting T. brucei metacaspase-2 at micromolar concentrations. Further research is essential to validate their …

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QUALITY OF LIFE AFTER HYSTERECTOMY: CLINICAL AND FUNCTIONAL ASSESSMENT OF WOMEN WITH GYNECOLOGICAL CONDITIONS

Clara Vallejo Alvarez, Lívia Vallone Kobbaz, Maria Rita Aquino, Sophia Beltrame Sawaya De Lima et autres

Hysterectomy is among the most frequently performed gynecological procedures worldwide and may produce important physical, emotional, and functional repercussions on women’s quality of life (QoL). This exploratory cross-sectional study evaluated the sociodemographic and clinical characteristics and quality of life of 116 women …

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Anxiety in medical students: curricular implications and evidence for institutional student support policies

Cesar Yudi Martins Yamashita, Enzo Meister, Gustavo Monteagudo Gibim, Rodrigo Ikegami Ottengy et autres

Introduction: Medical education is characterized by high academic demands and early exposure to human suffering, which favors the development of psychological distress. Anxiety is the most prevalent condition among medical students, with negative effects on academic performance and potential pathophysiological repercussions, including …

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Calcium dependence and biochemical characterization of metacaspase-3 from Trypanosoma cruzi

Ane Caroline Moreira Duarte, Vinícius Henrique De Oliveira, João Pedro Martins Silva Costa, Mariana Nascimento Romero Trujilho et autres

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Análise do absenteísmo em consultas e sua participação na descontinuidade do cuidado na atenção primária de saúde: revisão narrativa

Gabrielly Barros de Souza, Vitória Quesia Martins Santana, R. F. Oliveira, Maria Teresa Gagliazzi et autres

O absenteísmo em consultas e procedimentos na Atenção Primária à Saúde representa um desafio recorrente no Sistema Único de Saúde (SUS), comprometendo a continuidade do cuidado, a eficiência da gestão e a integralidade da assistência. Este estudo, de caráter qualitativo, descritivo e …

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The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

Ane Caroline Moreira Duarte, Mariana Nascimento Romero Trujilho, Karolaine Stella Siqueirade Moraes Valdivia, Aline F. Araujo et autres

Metacaspases are cysteine proteases found in fungi, protozoa, and plants, where they regulate critical cellular processes such as programmed cell death (PCD), cell cycle progression, and protein homeostasis. Although structurally related to caspases, metacaspases differ in mechanism of activation, substrate specificity, and …

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Alimentação e sono como pré-determinantes do rendimento acadêmico

Gabriela Rita Alves Colaço, M. Beatriz P.P. Oliveira, Matheus Gonçalves Della Nina Raffo, Allan Vinicius Santos do Prado et autres

A qualidade do sono e uma dieta equilibrada são cruciais para a saúde física, mental e o rendimento acadêmico, com privação de sono e má alimentação associadas a prejuízos cognitivos e aumento de doenças crônicas. O estudo investigou a relação entre alimentação, …

Impact of Burnout on medical students in the preclinical phase: analysis of emotional exhaustion, cynicism, and academic efficacy

felipe abrão saad, guilherme kenzo fujita, riccardo de oliveira milani, pedro vincenzi fachin et autres

The Burnout Syndrome has emerged as a critical phenomenon in the field of mental health, particularly among medical students, who face intense emotional and cognitive demands. Our objective was to investigate burnout levels among first- to third-year medical students. The study had …

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