Maria Pia Rigobello

Amino Oxidase Hard Protein Corona with Metabolic-Triggered Intracellular Biocatalysis

Federica Tonolo, Mary Bortoluzzi, Graziano Rilievo, Alessandro Cecconello et autres

A hard protein corona was engineered onto tannic acid-modified magnetic nanoparticles (SAMN@TA), a magnetic and luminescent core–shell nano-carrier, using bovine serum amine oxidase (BSAO), an enzyme catalyzing the oxidation of polyamines and producing the corresponding aldehydes and hydrogen peroxide. The absorption and …

From By-Product to Bioactive: New Antioxidant and Bioavailable Peptides Derived from Milk Permeate Targeting the Nrf2/Keap1 Pathway in Intestinal Cell Models

Valeria Scalcon, Alessandro Grinzato, Federico Fiorese, Alessandra Folda et autres

This study investigates the antioxidant properties of several synthetic peptides derived from milk proteins previously identified in milk permeate, a by-product of the dairy industry. The aim of the research is to identify which peptides present in milk permeate are responsible for …

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From Byproduct to Bioactive: New Antioxidant and Bioavailable Peptides Derived from Milk Permeate Targeting Nrf2/Keap1 Pathway in Intestinal Cell Models

Valeria Scalcon, Alessandro Grinzato, Federico Fiorese, Alessandra Folda et autres

Lactobionic Acid as a Biocompatibility Switch: Physicochemical and Biological Characterization of Copper(II)–Primaquine Complexes

Alessia Distefano, Laura Cifalinò, Alessia Sambugaro, Erik Murador et autres

Metal dyshomeostasis and oxidative stress are implicated in the progression of cancer, and neurodegenerative and peripheral aggregation-related disorders. In this study, we investigated primaquine (PQ), a clinically used antimalarial drug, and PQ-lactobionic acid conjugate (LAPQ), a newly synthesized and characterized derivative obtained …

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By-Products Valorization: Peptide Fractions from Milk Permeate Exert Antioxidant Activity in Cellular and In Vivo Models

Valeria Scalcon, Federico Fiorese, Marica Albanesi, Alessandra Folda et autres

The discarding of agri-food by-products is a stringent problem due to their high environmental impact. Recovery strategies can lead to a reduction of waste and result in new applications. Agri-food waste represents a source of bioactive molecules, which could promote health benefits. …

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Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems

Alessandra Folda, Valeria Scalcon, Federica Tonolo, Maria Pia Rigobello et autres

Thiamine (vitamin B1), under the proper conditions, is able to reversibly open the thiazole ring, forming a thiol-bearing molecule that can be further oxidized to the corresponding disulfide. To improve the bioavailability of the vitamin, several derivatives of thiamine in the thioester …

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Bioactive peptides from food waste: New innovative bio-nanocomplexes to enhance cellular uptake and biological effects

Federica Tonolo, Federico Fiorese, Graziano Rilievo, Alessandro Grinzato et autres

Mastitis is the most important bovine disease, causing dramatic economic losses to the dairy industry, worldwide. This study explores the valorization of whey from cows affected by mastitis, through a novel separation approach. Surface Active Maghemite Nanoparticles (SAMNs) were used as magnetic …

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The Role of Antioxidant Foods and Nutraceuticals in Ageing

Marco Giorgio, Maria Pia Rigobello

The free radical theory of aging proposed by Denham Harman in the 1950s identified the accumulation of oxidative damage over time as a cause of aging [...].

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Sunflower seed-derived bioactive peptides show antioxidant and anti-inflammatory activity: From in silico simulation to the animal model

Federica Tonolo, Sara Coletta, Federico Fiorese, Alessandro Grinzato et autres

The evolving field of food technology is increasingly dedicated to developing functional foods. This study explored bioactive peptides from sunflower protein isolate (SPI), obtained from defatted flour, a by-product of the oil processing industry. SPI underwent simulated gastrointestinal digestion and the obtained …

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Exploring the Anticancer Activity of Tamoxifen-Based Metal Complexes Targeting Mitochondria

Valeria Scalcon, Riccardo Bonsignore, Jana Aupič, Sophie R. Thomas et autres

High Resolution Image Download MS PowerPoint Slide Two new ‘hybrid’ metallodrugs of Au(III) (AuTAML) and Cu(II) (CuTAML) were designed featuring a tamoxifen-derived pharmacophore to ideally synergize the anticancer activity of both the metal center and the organic ligand. The compounds have antiproliferative …

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Mitochondrial targeting properties of new gold and copper complexes in breast cancer

Valeria Scalcon, Alessandra Folda, Riccardo Bonsignore, Jana Aupič et autres

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Fermentation of Corn By-Products: From Agrifood Waste to Higher Value Antioxidant Products

Federica Tonolo, Alessandra Folda, Stefania Ferro, Roberta Seraglia et autres

To improve the nutri-functional quality and, in particular, the antioxidant capacity of corn by-products, fermentation with selected lactic acid bacteria was carried out. To this purpose, white-1 and 2 and yellow corn by-products were fermented and then extracted. In all the samples, …

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