Accès ouvert
2025
article
OpenAlex
Changmi Deng, Haixia Zhou, Na Zhang, Min Chen et autres
Wilms tumour (WT) is the most predominant renal carcinoma that affects children, and the understanding of the genetic mechanisms underlying WT development is continually evolving. The role of the demethylase ALKBH1, which is known for its association with diverse cancers, in WT …
cn
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Accès ouvert
2025
article
OpenAlex
Tong‐Min Wang, Wenli Zhang, Jin-Ru Xie, Yong‐Qiao He et autres
Nasopharyngeal carcinoma is an aggressive malignancy originating from the nasopharyngeal mucosa and associated with genetic factors. Many nasopharyngeal carcinoma susceptibility loci have been identified by genome-wide association studies (GWASs), but their underlying functional insights are largely unexplained. A meta-GWAS including 5073 nasopharyngeal …
cn, us, hk, sg, no, se
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Accès ouvert
2025
article
OpenAlex
Changmi Deng, Jinhong Zhu, Fei Duan, Wenli Zhang et autres
BACKGROUND: Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is a gene encoding acetyltransferase, which is involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic …
cn
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Accès ouvert
2025
retraction
OpenAlex
Guannan Shu, Zhao Zhang, Tianxin Zhao, Changmi Deng et autres
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-024-03113-9.
cn
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Accès ouvert
2025
article
OpenAlex
Xiaokai Huang, Jinyu Lu, Changmi Deng, Weixian Tang et autres
BACKGROUND: A methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear. METHODS: We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls. The relationship …
cn
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Accès ouvert
2025
article
OpenAlex
Changmi Deng, Jinhong Zhu, Fei Duan, Min Chen et autres
Wilms tumor is a prevalent childhood kidney cancer, which is known to be influenced by genetic predisposition. TRMT10C plays a role in RNA modification and mitochondrial function. This study explored the associations of four TRMT10C variants with susceptibility to Wilms tumor in …
cn
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Accès ouvert
2024
article
OpenAlex
Shuang Wu, Changmi Deng, Yufeng Han, Wen Fu et autres
Wilms tumor is the most common kidney tumor in children aged 0-14 years. MicroRNAs are small, noncoding RNAs linked to the development of malignant tumors. Several studies have shown the association between single nucleotide polymorphism in miR-27a and cancer risk. This study …
cn
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2024
article
OpenAlex
Xueli Zhan, Haixia Zhou, Changmi Deng, Rui‐Xi Hua et autres
The nucleotide excision repair (NER) system is one of the main ways to protect organisms from DNA damage caused by endogenous and exogenous carcinogens. NER deficiency increases genome mutations, chromosomal aberrations, and cancer viability. However, the genetic association between Wilms tumor and …
cn
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Accès ouvert
2024
article
OpenAlex
Guannan Shu, Zhao Zhang, Tianxin Zhao, Changmi Deng et autres
Abstract Background The potential involvement of circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification in the progression of Wilms tumor (WT) has not been fully elucidated. This study investigates the regulatory mechanisms and clinical significance of m6A-modified circMARK2 and its role in WT …
cn
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Accès ouvert
2024
article
OpenAlex
Wen Fu, Linqing Deng, Xiaosong Yan, Rui‐Xi Hua et autres
BACKGROUND: Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the susceptibility to develop certain tumor types. Apart from LMO1, the LMO gene family …
cn
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Accès ouvert
2024
article
OpenAlex
Cao‐Li Tang, Xi‐Zhao Li, Ting Zhou, Changmi Deng et autres
BACKGROUND: As an oncovirus, EBV is associated with multiple cancers, including solid tumors and hematological malignancies. EBV methylation plays an important role in regulating tumor occurrence. However, the EBV methylation profiles in EBV-associated tumor tissues are poorly understood. RESULTS: In this study, …
cn
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Accès ouvert
2024
article
OpenAlex
Changmi Deng, Yufeng Han, Haixia Zhou, Jiao Zhang et autres
Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors.m 6 A modification is a common nucleotide modification that plays a role in a variety of cancers.As a "reader", YTHDF3 is essential for recognizing m 6 A modifications.However, the association …
cn
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