YTHDF3 gene polymorphisms increase Wilms tumor risk in Chinese girls
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Le résumé fourni par la source
Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors.m 6 A modification is a common nucleotide modification that plays a role in a variety of cancers.As a "reader", YTHDF3 is essential for recognizing m 6 A modifications.However, the association between YTHDF3 gene polymorphisms and Wilms tumor susceptibility has not been previously reported.A five-center casecontrol study including 414 patients and 1199 controls was conducted to explore the relationship between YTHDF3 gene polymorphisms and Wilms tumor susceptibility.The samples were genotyped via TaqMan real-time quantitative polymerase chain reaction.Odds ratios (ORs) and 95% confidence intervals (CIs) were utilized as indicators to assess their correlation.The YTHDF3 rs2241753 AA genotype was significantly associated with an increased risk of Wilms tumor in females (adjusted OR=1.74, 95% CI=1.05-2.88,P=0.033).The risk of Wilms tumor was also notably elevated in female children with 1-3 risk genotypes (adjusted OR=1.47, 95% CI=1.04-2.07,P=0.028).The YTHDF3 rs2241753 AA genotype and the presence of 1-3 risk genotypes were significantly associated with increased Wilms tumor risk in female children.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <i>YTHDF3</i> gene polymorphisms increase Wilms tumor risk in Chinese girls
- Date Crossref
- 01/01/2024
- Éditeur
- Ivyspring International Publisher
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease pays non établi dans la noticeStructure de recherche
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Guangzhou Medical University Department of Pediatric Surgery pays non établi dans la noticeUniversité ou école supérieure
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Wenzhou Medical University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Zhengzhou University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Xi'an Jiaotong University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Children Hospital and Women Health Center of Shanxi Department of Pathology pays non établi dans la noticeÉtablissement de santé
Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery — Guangzhou Medical University et Department of Hematology — Wenzhou Medical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.