Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study
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Le résumé fourni par la source
BACKGROUND: Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is a gene encoding acetyltransferase, which is involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic role of NAT10 in cancer has garnered significant attention. However, research on NAT10 genetic variants and their associations with cancer is nascent. METHODS: This study investigated the link between NAT10 genetic variants and Wilms tumor risk via a case‒control design with genomic DNA from 414 patients and 1199 controls. Genotyping was performed via the TaqMan method, and logistic regression statistical analysis was conducted to identify significant associations, followed by extra analysis to minimize false positive significant results. RESULTS: Our findings revealed that the rs8187 G > A polymorphism in the NAT10 gene is significantly correlated with a decreased risk of developing Wilms tumor (GA vs. GG, adjusted odds ratio (AOR) = 0.60, 95% confidence interval (CI) = 0.46-0.77, P < 0.0001; GA/AA vs. GG, AOR = 0.74, 95% CI = 0.59-0.93, P = 0.011). Stratified analyses further revealed a significant association in children aged 18 months or under and in subgroups with stage II, stage IV, or combined stage I + II tumors. CONCLUSION: These results highlight the potential of NAT10 rs8187 G > A polymorphism as genetic markers for Wilms tumor susceptibility. This study clarifies the genetic basis of Wilms tumor susceptibility and highlights the role of NAT10 rs8187 G > A polymorphism in early detection and risk assessment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study
- Date Crossref
- 17/03/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease pays non établi dans la noticeStructure de recherche
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Guangzhou Medical University Department of Pediatric Surgery pays non établi dans la noticeUniversité ou école supérieure
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Harbin Medical University Department of Clinical Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
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Hebei Medical University Department of Pediatric General Surgery pays non établi dans la noticeUniversité ou école supérieure
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Wenzhou Medical University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Zhengzhou University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Xi'an Jiaotong University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Guangzhou Women and Children Medical Center pays non établi dans la noticeÉtablissement de santé
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Children Hospital and Women Health Center of Shanxi Department of Pathology pays non établi dans la noticeÉtablissement de santé
Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery — Guangzhou Medical University et Department of Clinical Laboratory — Harbin Medical University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.