Jinyu Lu

A phase 1 study of PF-07260437, a B7-H4 × CD3 bispecific T-cell engager, in patients with advanced or metastatic breast, ovarian, and endometrial cancer

Fengting Yan, Marcia Cruz-Correa, Jennifer Specht, Wenge Wang et autres

B7-H4 is overexpressed in various cancers, making it a promising target for cancer immunotherapy. This phase 1, open-label, first-in-human study in patients with advanced/metastatic breast, ovarian and endometrial cancer evaluates the safety, pharmacokinetics (PK), and anti-tumour activity of PF-07260437, a novel B7-H4xCD3 …

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Reply to the Letter to the Editor: A deep learning framework to stratify Nottingham histologic grade 2 breast tumors based on dynamic contrast-enhanced MRI

Roham Hadidchi, Anchita Agrawal, Michael Z. Liu, Takouhie Maldjian et autres

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Absolute quantification of tricarboxylic acid (TCA) cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism

Cloe Ratliff, David Hansman, Tuan Ngo, Yinxiao Xiang et autres

The mitochondrial tricarboxylic acid (TCA) cycle is central to cellular energy production and redox homeostasis in the eye, which must sustain exceptionally high metabolic activity to support vision. Retinal neurons, the retinal pigment epithelium (RPE), cornea, and lens perform distinct physiological functions …

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Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children

Xiaokai Huang, Jinyu Lu, Changmi Deng, Weixian Tang et autres

BACKGROUND: A methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear. METHODS: We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls. The relationship …

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Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor

Yaping Yan, Lanxiao Cao, Luyan Gu, Congying Xu et autres

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691 A phase I study of AN4005, an orally available PD-L1 inhibitor, in patients with advanced tumors: safety and preliminary efficacy

Yanqiao Zhang, Jinyu Lu, David Levitz, Xiaorong Dong et autres

Background AN4005 is an orally available, small-molecule programmed cell death ligand 1 (PD-L1) inhibitor that demonstrates antitumor activity by blocking the interaction between PD-L1 and programmed cell death-1 (PD-1). In animal studies, AN4005 demonstrated tumor growth inhibition comparable to that of anti-PD-L1 …

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Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China

Zhilin Zheng, Zeyu Zhu, Jiali Pu, Chen Zhou et autres

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Analysis of common genetic variation of anxiety disorders in essential tremor

Yaping Yan, Lanxiao Cao, Luyan Gu, Congying Xu et autres

Abstract Objective To explore the association of common genetic variation of anxiety disorders and essential tremor (ET). Methods We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 505 age and gender-matched healthy controls from eastern China …

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Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China

Zhilin Zheng, Zeyu Zhu, Jiali Pu, Zhou Chen et autres

Abstract BackgroundEssential tremor (ET) is a neurological disease characterized by action tremor in upper arms. Although its high heritability and prevalence worldwide, its etiology and association with other diseases are still unknown.MethodWe investigated 10 common spinocerebellar ataxias (SCAs), including SCA1, SCA2, SCA3, …

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Association Analysis of 27 Single Nucleotide Polymorphisms in a Chinese Population with Essential Tremor

Lanxiao Cao, Luyan Gu, Jiali Pu, Dayao Lv et autres

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Brain microstructural changes in essential tremor patients and correlations with clinical characteristics: a diffusion kurtosis imaging study

Jinyu Lu, Cheng Zhou, Jiali Pu, Jun Tian et autres

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Noninvasive neuroimaging provides evidence for deterioration of the glymphatic system in Parkinson's disease relative to essential tremor

Luyan Gu, Shaobing Dai, Tao Guo, Xiaoli Si et autres

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