Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children
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Le résumé fourni par la source
BACKGROUND: A methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear. METHODS: We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls. The relationship between the genotype of each sublayer and the risk of Wilms tumor was studied by stratified analysis. The GTEx database was used to analyze the influence of TRMT61B rs4563180 G > C polymorphism on mRNA expression. RESULTS: The TRMT61B gene polymorphism significantly reduced the susceptibility to Wilms tumor (GC vs. GG: adjusted odds ratio [AOR] = 0.72, 95% confidence interval [CI] = 0.56-0.93, P = 0.012; GC/CC vs. GG: AOR = 0.76, 95% CI = 0.60-0.96, P = 0.021). GC/CC genotype had a protective effect in boys and children with stage III tumors compared with rs4563180 GG genotype. Additionally, the C allele was significantly associated with decreased mRNA expression of TRMT61B gene compared with rs4563180G allele in cultured fibroblasts (P = 3.3e - 80), EBV-transformed lymphocytes (P = 9.5e - 14), and whole blood (P = 6.0e - 12). CONCLUSIONS: Our results confirm that TRMT61B gene is associated with the development of Wilms tumors, but its underlying mechanism requires further exploration.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children
- Date Crossref
- 14/02/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wenzhou Medical University Department of Hematology pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University pays non établi dans la noticeÉtablissement de santé
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Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease pays non établi dans la noticeStructure de recherche
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Guangzhou Medical University Department of Pediatric Surgery pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Zhengzhou University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Xi'an Jiaotong University Department of Pediatric Surgery pays non établi dans la noticeÉtablissement de santé
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Guangzhou Women and Children Medical Center pays non établi dans la noticeÉtablissement de santé
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Children Hospital and Women Health Center of Shanxi Department of Pathology pays non établi dans la noticeÉtablissement de santé
Department of Hematology — Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University et Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.