Accès ouvert
2025
article
OpenAlex
Johannes Wedel, Nora M. Kochupurakkal, Sek Won Kong, Sayantan Bose et autres
Coinhibitory receptors function as central modulators of the immune response to resolve T effector activation and/or to sustain immune homeostasis. Here, using humanized SCID mice, we found that neuropilin-2 (NRP2) is inducible on late effector and exhausted subsets of human CD4+ T …
us, gb
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Johannes Wedel, Nora M. Kochupurakkal, Sek Won Kong, Sayantan Bose et autres
Abstract Co-inhibitory receptors function as central modulators of the immune response to resolve T effector activation and/or to sustain immune homeostasis. Here, using humanized SCID mice, we found that NRP2 is inducible on late effector and exhausted subsets of human CD4 + …
us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Johannes Wedel, Hironao Nakayama, Nora M. Kochupurakkal, Josephine Koch et autres
PURPOSE OF REVIEW: Chronic rejection is associated with persistent mononuclear cell recruitment, endothelial activation and proliferation, local tissue hypoxia and related biology that enhance effector immune responses. In contrast, the tumor microenvironment elicits signals/factors that inhibit effector T cell responses and rather …
us, jp
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Linda Männ, Nora M. Kochupurakkal, Christian Martin, Eva Verjans et autres
To assess the role of alveolar macrophages (AMs) during a pulmonary Aspergillus fumigatus infection AMs were depleted by intratracheal application of diphtheria toxin (DTX) to transgenic CD11c.DTR mice prior to fungal infection. Unexpectedly, all CD11c.DTR mice treated with DTX died within 4-5 …
ch, de, il
(code pays fourni par la source)
Accès ouvert
2015
article
OpenAlex
Hironao Nakayama, Sarah Bruneau, Nora M. Kochupurakkal, Sílvia Coma et autres
Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its mechanism(s) of function is poorly understood. Here, we …
us
(code pays fourni par la source)
Accès ouvert
2015
article
OpenAlex
Johannes Wedel, Sarah Bruneau, Nora M. Kochupurakkal, Leo Boneschansker et autres
PURPOSE OF REVIEW: New developments suggest that the graft itself and molecules expressed within the graft microenvironment dictate the phenotype and evolution of chronic rejection. RECENT FINDINGS: Once ischemia-reperfusion injury, cellular and humoral immune responses target the microvasculature, the associated local tissue …
us
(code pays fourni par la source)
2014
article
OpenAlex
Hironao Nakayama, Sarah Bruneau, Nora M. Kochupurakkal, Michael Klagsbrun et autres
Class three semaphorins, well characterized as axon guidance molecules, act via neuropilin (NRP) and plexin family receptors and elicit signals, resulting in anti-migration and cytoskeleton collapse. Recently, we have demonstrated that a) Semaphorin 3F (SEMA3F) is potent to inhibit allograft rejection in …
us, gb
(code pays fourni par la source)
2014
article
OpenAlex
Matthew M. Sheehan, Matthew Stack, Takeshi Seto, K. Liu et autres
An understanding of the alloimmune response and events leading to immunoregulation is required to optimize long-term allograft survival. TSAd, an SH2 domain containing intracellular adapter molecule, functions to elicit T cell receptor-mediated signals that result in effector T cell (Teff) cytokine production …
us
(code pays fourni par la source)
2014
article
OpenAlex
E. Lee, Nora M. Kochupurakkal, Hironao Nakayama, Hyunggun Kim et autres
Background: Neuropilins (NRP1 and NRP2) serve as receptors for class 3 family semaphorins and were originally described as axonal guidance molecules. More recently, NRP1 has been found to be highly expressed on most CD4+Foxp3+ regulatory T cells (Treg) and to facilitate DC-Treg …
gb, us
(code pays fourni par la source)
2014
article
OpenAlex
Nora M. Kochupurakkal, Hironao Nakayama, G. Demirci, K. Macleaod et autres
The class3 semaphorins (Sema3A-G) bind to Neuropilin/Plexin complexes on tumor cells and elicit regulatory signals, anti-migration and anti-proliferation. Recently, we found that Sema3F modulates PI-3K-Akt and MAPK signaling via neuropilin-2 (NRP-2), suggesting that this ligand-receptor interaction may be potent to inhibit T …
us, gb
(code pays fourni par la source)
Accès ouvert
2014
article
OpenAlex
Nora M. Kochupurakkal, Annie J. Kruger, Sudipta Tripathi, Bing Mei Zhu et autres
AIMS/HYPOTHESIS: Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not …
us, gb
(code pays fourni par la source)
Accès ouvert
2013
article
OpenAlex
Leonardo Vidal Riella, Shirine Dada, Lola Chabtini, Brian D. Smith et autres
In a successful pregnancy, the semiallogeneic fetus is not rejected by the maternal immune system, which implies tolerance mechanisms protecting fetal tissues from maternal immune attack. Here we report that the ICOS-B7h costimulatory pathway plays a critical role in maintaining the equilibrium …
us, jp
(code pays fourni par la source)