Leo Boneschansker

Dual Targeted Therapy With Risankizumab and Upadacitinib in Refractory Ulcerative Colitis

Padmavathi Srivoleti, Nireet Dhillon, Leo Boneschansker

Medically refractory acute severe ulcerative colitis (UC) remains a major therapeutic challenge. We describe a 39-year-old woman with multiple prior treatment failures who presented with a steroid-refractory UC flare. Given that she was symptomatic despite high-dose upadacitinib, dual targeted therapy with upadacitinib …

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Delayed Remission With Advanced Therapies Is Not Associated With Worse 1-Year Outcomes in Inflammatory Bowel Disease

Sara Ghoneim, Heather Choe, Leo Boneschansker, Karan Sachdeva et autres

INTRODUCTION: In randomized trials, early improvement with biologic therapy in Crohn's disease (CD) and ulcerative colitis (UC) is linked to better long-term outcomes. However, some patients may respond later (late remitters). The frequency of such late remitters, predictors of who may belong …

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267: DELAYED REMISSION WITH ADVANCED THERAPY IS NOT ASSOCIATED WITH WORSE ONE-YEAR OUTCOMES IN INFLAMMATORY BOWEL DISEASE

Sara Ghoneim, Heather Choe, Leo Boneschansker, Karan Sachdeva et autres

Immunomodulation by allograft endothelial cells

Sayantan Bose, Vicki Do, Chiara Testini, Suchita Suryakant Jadhav et autres

It is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. We propose that differences in the phenotype of …

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Beyond the Gut: The Epidemiology of Extraintestinal Manifestations in Inflammatory Bowel Disease

Leo Boneschansker, Kristin E. Burke

Inflammatory bowel diseases (Crohn's disease, ulcerative colitis) are chronic immune-mediated diseases of the gastrointestinal tract that are associated with many extraintestinal manifestations (EIMs). EIMs can affect nearly any organ system and are associated with impaired quality of life. This issue of The …

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Upadacitinib as a Novel Treatment in Therapy Refractory Collagenous Colitis

Leo Boneschansker, Kristin E. Burke

Microscopic colitis (MC) is an inflammatory disorder of the colon histologically subclassified into lymphocytic colitis (LC) and collagenous colitis (CC).1,2 Budesonide is an effective first-line treatment in both forms of MC. However treatment-refractory disease, particularly in CC, remains a challenging clinical problem.3,4 …

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Tu1807 PRIOR TREATMENT WITH TOFACITINIB DOES NOT AFFECT INITIAL RESPONSE TO UPADACITINIB IN ULCERATIVE COLITIS

Leo Boneschansker, Bharati D. Kochar, Emily Walsh Lopes, Francis P. Colizzo et autres

Comparative Effectiveness of Upadacitinib and Tofacitinib in Inducing Remission in Ulcerative Colitis: Real-World Data

Leo Boneschansker, Ashwin N. Ananthakrishnan, Kristin E. Burke, Bharati D. Kochar et autres

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Improving the Consent Process With an Informed Consent Video Prior to Outpatient Colonoscopy

Emily Walsh Lopes, Leo Boneschansker, Jacqueline N. Chu, Jasmine B. Ha et autres

Background and Aims Informed consent should allow patients the appropriate time and conditions to make decisions about their care. However, consent is often obtained immediately prior to a colonoscopy. We conducted a quality improvement study to assess how a preprocedure consent video …

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S1878 A Case of Type II Autoimmune Pancreatitis in a Patient Treated With Pembrolizumab Adjuvant Therapy

Leo Boneschansker, Avinash R. Kambadakone, Oladapo Yeku, Martha B. Pitman et autres

Introduction: Immune checkpoint inhibitor (ICI)-therapy causes GI toxicity but its association with mass-forming Type II AIP has not been described. While pancreatic manifestations of ICI-toxicity are known, it does not include mass-forming AIP. This case demonstrates development of a worrisome pancreatic mass …

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Collaborative GI Fellow Project: Improving the Consent Process With an Informational Video Prior to Outpatient Colonoscopy

Emily Walsh Lopes, Leo Boneschansker, Jacqueline N. Chu, James M. Richter et autres

503: COLLABORATIVE GI FELLOW PROJECT: IMPROVING THE CONSENT PROCESS WITH AN INFORMATIONAL VIDEO PRIOR TO OUTPATIENT COLONOSCOPY

Emily Walsh Lopes, Leo Boneschansker, Jacqueline N. Chu, James M. Richter et autres