William B. Fulton

Transcutaneous auricular vagus nerve stimulation attenuates neuroinflammation in a mouse model of traumatic brain injury

Mahmoud G. El Baassiri, Leonard Lawandos, Daniel J. Scheese, Cody J. Tragesser et autres

INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Although TBI pathophysiology has been thoroughly investigated, the effectivity of therapeutic approaches for TBI is still lacking. Our group has developed a novel approach of noninvasive transcutaneous auricular …

us (code pays fourni par la source)

Maternal nicotine vaping activates neonatal innate immunity in mice 3745

Sierra Williams-McLeod, Aishat Fagun, A. James Mason, Koichi Tsuboi et autres

Abstract Description Electronic cigarettes, also known as e-cigarettes or vapes, are battery-operated devices that heat and produce aerosols for inhalation. Maternal nicotine e-cigarette use during pregnancy can have detrimental effects on fetal growth and development, which may be in part due to …

us (code pays fourni par la source)

Ccr2-dependent monocytes exacerbate intestinal inflammation and modulate gut serotonergic signaling following traumatic brain injury

Mahmoud G. El Baassiri, Zachariah Raouf, Hee‐Seong Jang, Daniel J. Scheese et autres

BACKGROUND: Traumatic brain injury (TBI) leads to acute gastrointestinal dysfunction and mucosal damage, resulting in feeding intolerance. C-C motif chemokine receptor 2 (Ccr2 + ) monocytes are crucial immune cells that regulate the gut's inflammatory response via the brain-gut axis. Using Ccr2 …

us (code pays fourni par la source)

Colitis-Induced Small Intestinal Hypomotility Is Dependent on Enteroendocrine Cell Loss in Mice

Zachariah Raouf, Steve N. Steinway, Daniel J. Scheese, Carla Marisa Lopez et autres

BACKGROUND & AIMS: The abdominal discomfort experienced by patients with colitis may be attributable in part to the presence of small intestinal dysmotility, yet mechanisms linking colonic inflammation with small-bowel motility remain largely unexplored. We hypothesize that colitis results in small intestinal …

us (code pays fourni par la source)

507 OCCURRENCE OF SMALL INTESTINAL DYSMOTILITY IN A MURINE MODEL OF DSS-COLITIS IS ASSOCIATED WITH ALTERED SEROTONERGIC SIGNALING

Zachariah Raouf, Steven Nathaniel Steinway, Dan Scheese, Hannah Moore et autres

Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice

Chhinder Pal Sodhi, Raheel Ahmad, William B. Fulton, Carla Marisa Lopez et autres

This study reveals that the administration of human milk oligosaccharides, which are present in human breast milk, can interfere with the proinflammatory gut-brain axis and prevent neuroinflammation in the setting of necrotizing enterocolitis, a major intestinal disorder seen in premature infants.

us (code pays fourni par la source)

Pharmacologic Toll-like receptor 4 inhibition skews toward a favorable A1/A2 astrocytic ratio improving neurocognitive outcomes following traumatic brain injury

Mahmoud G. El Baassiri, Simon S. Rahal, William B. Fulton, Chhinder Pal Sodhi et autres

BACKGROUND: Astrocytes are critical neuroimmune cells that modulate the neuroinflammatory response following traumatic brain injury (TBI) because of their ability to acquire neurotoxic (A1) or neuroprotective (A2) phenotypes. Using C34, a novel pharmacologic Toll-like receptor (TLR) 4 inhibitor, we explored their respective …

us (code pays fourni par la source)

Infiltrating anti-inflammatory monocytes modulate microglial activation through toll-like receptor 4/interferon–dependent pathways following traumatic brain injury

Mahmoud G. El Baassiri, Young Hak Chun, Simon S. Rahal, William B. Fulton et autres

BACKGROUND: Traumatic brain injury (TBI) is the leading cause of morbidity and mortality in the pediatric population. Microglia and infiltrating monocyte-derived macrophages are crucial immune cells that modulate the neuroinflammatory response following TBI. Using C34, a novel pharmacologic toll-like receptor 4 inhibitor, …

us (code pays fourni par la source)

The administration of amnion-derived multipotent cell secretome ST266 protects against necrotizing enterocolitis in mice and piglets

Chhinder Pal Sodhi, Raheel Ahmad, Hongpeng Jia, William B. Fulton et autres

This work provides hope for children who develop NEC, a devastating disease of premature infants that is often fatal, by revealing that the secreted product of amniotic progenitor cells (called ST266) can prevent or treat NEC in mice, piglet, and "NEC-in-a-dish" models …

us (code pays fourni par la source)

The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice

Chhinder Pal Sodhi, Andres J. Gonzalez Salazar, Mark L. Kovler, William B. Fulton et autres

Necrotising enterocolitis (NEC) is a devastating gastrointestinal disease of prematurity that typically develops after the administration of infant formula, suggesting a link between nutritional components and disease development. One of the most significant complications that develops in patients with NEC is severe …

us (code pays fourni par la source)

Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

Mark L. Kovler, Andres J. Gonzalez Salazar, William B. Fulton, Peng Lü et autres

) did not show NEC-induced enteric glia depletion and were protected from NEC. Mechanistically, brain-derived neurotrophic factor (BDNF) from enteric glia restrained TLR4 signaling on the intestine to prevent NEC. BDNF was reduced in mouse and human NEC, and BDNF administration reduced …

us (code pays fourni par la source)

573 THE HUMAN MILK OLIGOSACCHARIDES 2’-FUCOSYLLACTOSE AND 6’-SIAYLLACTOSE ATTENUATE NEC-ASSOCIATED BRAIN INJURY

Andres J. Gonzalez Salazar, Qinjie Zhou, Mark L. Kovler, Diego F. Niño et autres