Qinjie Zhou

Adaptive Brightness Enhancement Algorithm of Small Celestial Bodies Based on Knowledge Embedded

Qinjie Zhou, Guo Wei, Mingda Jin, Haning Xiu et autres

The economic and scientific value that small celestial bodies (SCBs) offer humanity is the main motivation for close exploration of these bodies. However, autonomous optical navigation is challenging due to the light variation caused by the rapid spin of SCBs. In this …

cn, us (code pays fourni par la source)

Unsupervised Enhancement Model for Brightness Equalization of Small Celestial Body

Qinjie Zhou, Wei Shao

The economic and scientific value that small celestial bodies (SCBs) offer humanity are the main motivations for close exploration of these bodies. However, optical autonomous navigation becomes challenging due to the light variation caused by the rapid spin of SCBs. In this …

cn (code pays fourni par la source)

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

Sarah A. Kazzaz, Kashif A. Shaikh, Jesse White, Qinjie Zhou et autres

The innate antiviral response to RNA viruses is initiated by sensing of viral RNAs by RIG-I-like receptors and elicits type I interferon (IFN) production, which stimulates the expression of IFN-stimulated genes that orchestrate the antiviral response to prevent systemic infection. Negative regulation …

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Breastfeeding woes: a family physician’s approach

Qinjie Zhou, Yeow Leng Tan, CH How, Liying Yang

WHAT IS BREASTFEEDING?Breastfeeding is the process of feeding a mother's breast milk to her infant, either directly from the breast or after expression.(1) Breastfeeding and breast milk provide an infant with calories and nutrients, including macronutrients (fat, protein and carbohydrates) and micronutrients …

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490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors

Elaine Shum, Han Myint, Jahangheer S. Shaik, Qinjie Zhou et autres

Background Siglec-15 (S15) is a member of the Siglec family of immunoglobulin superfamily proteins involved in immune regulation. NC318 is a first-in-class humanized IgG1κ monoclonal antibody that blocks S15-mediated immune suppression. Methods The Phase 1 dose-escalation study was a classical 3+3 design …

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487 NC410, a fusion protein of LAIR-2 (Leukocyte Associated Immunoglobulin-like Receptor) with human IgG1 Fc, is safe & tolerable with evidence of immune modulation in subjects with advanced solid tumors

Han Myint, Linjie Tian, Jahangheer S. Shaik, Emilia Barbu et autres

Background Collagen and C1q in the extracellular matrix (ECM), are the predominant ligands for LAIR-1, an inhibitory receptor expressed on the cell surface of several immune cell subsets that inhibits immune activation and migration. LAIR-2, a soluble homolog of LAIR-1, competes for …

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Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

Mark L. Kovler, Andres J. Gonzalez Salazar, William B. Fulton, Peng Lü et autres

) did not show NEC-induced enteric glia depletion and were protected from NEC. Mechanistically, brain-derived neurotrophic factor (BDNF) from enteric glia restrained TLR4 signaling on the intestine to prevent NEC. BDNF was reduced in mouse and human NEC, and BDNF administration reduced …

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573 THE HUMAN MILK OLIGOSACCHARIDES 2’-FUCOSYLLACTOSE AND 6’-SIAYLLACTOSE ATTENUATE NEC-ASSOCIATED BRAIN INJURY

Andres J. Gonzalez Salazar, Qinjie Zhou, Mark L. Kovler, Diego F. Niño et autres

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Peng Lü, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang et autres

Necrotizing enterocolitis (NEC) is a disease of premature infants characterized by acute intestinal necrosis. Current dogma suggests that NEC develops in response to post-natal dietary and bacterial factors, and so a potential role for in utero factors in NEC remains unexplored. We …

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Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain

Qinjie Zhou, Diego F. Niño, Yukihiro Yamaguchi, Sanxia Wang et autres

T cells, suggesting that early management of intestinal inflammation in children with NEC could improve neurological outcomes.

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Insights image for “The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.”

Chhinder Pal Sodhi, Peter Wipf, Yukihiro Yamaguchi, William B. Fulton et autres

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The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Chhinder Pal Sodhi, Peter Wipf, Yukihiro Yamaguchi, William B. Fulton et autres

us (code pays fourni par la source)