Koichi Tsuboi

Maternal nicotine vaping activates neonatal innate immunity in mice 3745

Sierra Williams-McLeod, Aishat Fagun, A. James Mason, Koichi Tsuboi et autres

Abstract Description Electronic cigarettes, also known as e-cigarettes or vapes, are battery-operated devices that heat and produce aerosols for inhalation. Maternal nicotine e-cigarette use during pregnancy can have detrimental effects on fetal growth and development, which may be in part due to …

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Heat exposure impacts the incidence of intussusception in children

Koichi Tsuboi, Chhinder P. Sodhi

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Necrotizing enterocolitis: specific human milk oligosaccharides prevent enteric glia loss and hypomotility

Chhinder Pal Sodhi, Daniel J. Scheese, Cody J. Tragesser, William B. Fulton et autres

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Xenotransplanted human organoids identify transepithelial zinc transport as a key mediator of intestinal adaptation

Maame Efua Sampah, Hannah Moore, Raheel Ahmad, Johannes Wolfgang Duess et autres

Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small intestinal organoids explanted from mice with experimental SBS. …

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Necrotizing enterocolitis, gut microbes, and sepsis

Johannes Wolfgang Duess, Maame Efua Sampah, Carla Marisa Lopez, Koichi Tsuboi et autres

Necrotizing enterocolitis (NEC) is a devastating disease in premature infants and the leading cause of death and disability from gastrointestinal disease in this vulnerable population. Although the pathophysiology of NEC remains incompletely understood, current thinking indicates that the disease develops in response …

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507 OCCURRENCE OF SMALL INTESTINAL DYSMOTILITY IN A MURINE MODEL OF DSS-COLITIS IS ASSOCIATED WITH ALTERED SEROTONERGIC SIGNALING

Zachariah Raouf, Steven Nathaniel Steinway, Dan Scheese, Hannah Moore et autres

Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice

Chhinder Pal Sodhi, Raheel Ahmad, William B. Fulton, Carla Marisa Lopez et autres

This study reveals that the administration of human milk oligosaccharides, which are present in human breast milk, can interfere with the proinflammatory gut-brain axis and prevent neuroinflammation in the setting of necrotizing enterocolitis, a major intestinal disorder seen in premature infants.

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Hydrogen Embrittlement by Formation of Stable Austenite-Layer in Metastable Austenitic Stainless Steel

耕一 坪井, Koichi Tsuboi, 拓朗 増村, Takuro Masumura et autres

Thermodynamics and kinetics of solution nitriding

Nobuo Nakada, Koichi Tsuboi, Tatsuro Onomoto, Toshihiro Tsuchiyama et autres

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Suppression of hydrogen embrittlement by formation of a stable austenite layer in metastable austenitic stainless steel

Toshihiro Tsuchiyama, Koichi Tsuboi, Shuichi Iwanaga, Takuro Masumura et autres

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Effect of ultra-grain refinement on the tensile behaviour of an austenitic steel charged with hydrogen

Arnaud Macadre, Koichi Tsuboi, Nobuo Nakada, Toshihiro Tsuchiyama et autres

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Ultra-grain Refinement Effect on Tensile and Phase Transformation Behaviour in a Metastable Austenitic Steel Charged in Hydrogen Gas

Arnaud Macadre, Koichi Tsuboi, Nobuo Nakada, Toshihiro Tsuchiyama et autres

To ensure the safety of hydrogen systems, materials must be selected according to strength levels and susceptibility to hydrogen. Austenitic steels are notoriously resistant to hydrogen embrittlement, but usually suffer from relatively low strength levels. In this study, the material used is …

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