Accès ouvert déclaré
2022
article
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno–Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martín, Benjamin Grenier‐Boley, Víctor Andrade, Peter Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belén Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merçé Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Geneviève Chêne, Jaeyoon Chung, Michael L. Cuccaro, Ãngel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Hung‐Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Kátia de Paiva Lopes, Lot D. de Witte, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Anita L. DeStefano, Martin Dichgans, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott‐Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Fabrizio Tagliavini, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández‐Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. Bullido, Ana Frank, Lutz Froelich, Brian Fulton‐Howard, Daniela Galimberti, José María García‐Alberca, Sebastián García‐Madrona, Guillermo García‐Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González‐Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Michelle Grunin, Vilmundur Guðnason, Tamar Guetta‐Baranes, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton‐Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann‐Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernández, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda Kuzma, Carmen Lage, Erika J. Laukka, Lenore J. Launer, Alessandra Lauria, Chien‐Yueh Lee, Jenni Lehtisalo, Ondřej Lerch, Alberto Lleó, W.T. Longstreth, Oscar L. López, Adolfo López de Munain, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macías, Catherine Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié, Iain Marshall, Eden R. Martin, Ángel Martín Montes, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez‐González, Pablo Mir, Susanne Moebus, Merel O. Mol, Laura Molina‐Porcel, Laura Montrreal, Laura Morelli, Fermín Moreno, Kevin Morgan, Markus M. Nöthen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gaël Nicolas, Børge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Paolo Caffarra, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Gina M. Peloso, Alba Pérez‐Cordón, Jordi Pérez‐Tur, Pierre Péricard, Oliver Peters, Yolande A.L. Pijnenburg, Juan A. Pineda, Gerard Piñol-Ripoll, Claudia Pisanu, Thomas Polak, Julius Popp, Daniëlle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Inés Quintela, Jesper Qvist Thomassen, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luís Miguel Real, Marcel Reinders, Christiane Reitz, Dolly Reyes‐Dumeyer, Perry Ridge, Steffi G. Riedel‐Heller, Peter Riederer, Natalia Roberto, Eloy Rodríguez‐Rodríguez, Arvid Rongve, Irene Rosas Allende, Maitée Rosende-Roca, José Luís Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez, Paraskevi Sakka, Ingvild Saltvedt, Ángela Sanabria, María Bernal Sánchez‐Arjona, Florentino Sánchez-García, Pascual Sánchez‐Juan, Raquel Sánchez‐Valle, Sigrid B. Sando, Chloé Sarnowski, Claudia L. Satizábal, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M. Schott, Geir Selbæk, Davide Seripa, Manuel Serrano‐Ríos, Jin Sha, Alexey Shadrin, Olivia Anna Skrobot, Susan Slifer, Gijsje J. L. Snijders, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Yeunjoo E. Song, Sandro Sorbi, Óscar Sotolongo‐Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluís Tárraga, Niccoló Tesi, Anbupalam Thalamuthu, Thomas Tegos, Giuseppe Tosto, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjærg-Hansen, André G. Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares, Christine Van Broeckhoven, Jeffery M. Vance, Badri N. Vardarajan, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, John C. van Swieten, Rik Vandenberghe, Frans Verhey, Jean‐Sébastien Vidal, Jonathan Vogelgsang, Martin Vyhnálek, Michael Wagner, David Wallon, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, Miren Zulaica, Jan Laczó, Václav Maťoška, María Serpente, Francesca Assogna, Fabrizio Piras, Federica Piras, Valentina Ciullo, Jacob Shofany, Carlo Ferrarese, Simona Andreoni, Gessica Sala, Chiara Paola Zoia, Maria Del Zompo, Alberto Benussi, Patrizia Bastiani, Mari Takalo, Teemu Natunen, Tiina Laatikainen, Jaakko Tuomilehto, Riitta Antikainen, Timo Strandberg, Jaana Lindström, Markku Peltonen, Richard Abraham, Ammar Al‐Chalabi, Nicholas J. Bass, Carol Brayne, Kristelle S. Brown, John Collinge, David Craig, Pangiotis Deloukas, Amy Gerrish, Michael Gill, Rhian Gwilliam, Denise Harold, Paul Hollingworth, Jarret A. Johnston, Lesley Jones, Brian Lawlor, Gill Livingston, Simon Lovestone, Michelle K. Lupton, Aoibhinn Lynch, David Mann, Bernadette McGuinness, Andrew McQuillin, Michael O‘Donovan, Michael J. Owen, Peter Passmore, John Powell, Christopher E. Shaw, A. David Smith, H. Gurling, Stephen Todd, Catherine J. Mummery, Nathalie Ryan, Giordano Lacidogna, Ad Adarmes-Gómez, Ana Mauleón, Ana Pancho, A. Gailhajenet, Asunción Lafuente, Daniel Macías‐García, Elvira Martín, Esther Pelejà, F. Carrillo, Isabel Sastre Merlín, L. Garrote-Espina, Liliana Vargas, Mario Carrión‐Claro, M. Marín, Ma Labrador, Mar Buendía, M. D. Alonso, Marina Guitart, Mariona Moreno, Marta Ibarria, Mt Periñán, Núria Aguilera, Pilar Gómez‐Garre, Rocío Pineda-Sánchez, R. Vigo-Ortega, Silvia Jesús, Sílvia Preckler, Silvia Rodrigo‐Herrero, Susana Diego, Alessandro Vacca, Fausto Roveta, Nicola Salvadori, Elena Chipi, Henning Boecker, Christoph Laske, Robert Perneczky, Costas A. Anastasiou, Daniel Janowitz, Rainer Malik, Anna Anastasiou, Kayenat Parveen, Sara López‐García, Anna Antonell, Kalina Mihova, Diyana Belezhanska, Heike Weber, Silvia Kochen, Patricia Solís, Nancy Medel, Julieta Lisso, Zulma Sevillano, Daniel G. Politis, Valeria Cores, Carolina Cuesta, Cecilia Ortiz, Juan Ignacio Bacha, Mario Rios, Aldo Saenz, Mariana Sanchez Abalos, Eduardo Köhler, Dana Lis Palacio, Ignacio Etchepareborda, Matias Köhler, Gisela V. Novack, Federico Ariel Prestia, Pablo Galeano, Eduardo M. Castaño, Sandra Germani, Carlos Reyes Toso, Matias Rojo, Carlos A. Ingino, Carlos Mangone, David C. Rubinsztein, Stefan Teipel, Nathalie Fiévet, Vincent Deramerourt, Charlotte Forsell, Håkan Thonberg, Maria Bjerke, Ellen De Roeck, Nicholas G. Martin, Natividad Olivar, Amanda Cano, Olalla Maroñas, Raúl Núñez‐Llaves, Clàudia Olivé, E. Pelejà, Astrid D. Adarmes-Gómez, Guillermo Amer-Ferrer, Martirio Antequera, J A Burguera, Fátima Carrillo, M. J. Casajeros, Marian M. de Pancorbo, S. Hevilla, M. A. Labrador Espinosa, Agustina Legaz, Salvadora Manzanares, Marta Marín‐Oto, Juan Marín-Muñoz, Tamara Marín, Begoña Martínez, Victoriana Martínez, Pablo Martínez-Lage Álvarez, María Teresa Periñán-Tocino, Diego Real de Asúa, Silvia Rodrigo, I. Sastre, M.P. Vicente, Liliana Vivancos, Jacques Epelbaum, Didier Hannequin, Dominique Campion, Vincent Deramecourt, Christophe Tzourio, Alexis Brice, Bruno Dubois, Amy L. Williams, Charlene Thomas, Chloe Davies, Will Nash, Kimberley Dowzell, Atahualpa Castillo-Morales, Mateus Bernardo-Harrington, James Turton, Jenny Lord, Emma Vardy, Elizabeth Fisher, Jason D. Warren, Natalie S. Ryan, Rita Guerreiro, James Uphill, Reinhard Heun, Heike Kölsch, Britta Schürmann, André Lacour, Christine Herold, Janet Johnston, Yogen Patel, Angela Hodges, Tim Becker, Donald Warden, Gordon Wilcock, Robert Clarke, Yoav Ben‐Shlomo, Nigel M. Hooper, Stuart Pickering‐Brown, Rebecca Sussams, Isabella Heuser, Dmitriy Drichel, Norman Klopp, Manuel Mayhaus, Sabrina Pinchler, Thomas Feulner, Wei Gu, Hendrik van den Bussche, Michael Hüll, Lutz Frölich, H-Erich Wichmann, Karl‐Heinz Jöckel, Michael J. Owen, Shahram Bahrami, Ingunn Bosnes, Per Selnes, Sverre Bergh, Aarno Palotie, Mark J. Daly, Howard J. Jacob, Athena Matakidou, Heiko Runz, Sally John, Robert M. Plenge, Mark McCarthy, Meg Ehm, Dawn Waterworth, Caroline S. Fox, Anders Mälarstig, Kathy Klinger, Kathy Call, Timothy E.J. Behrens, Patrick Loerch, Tomi P. Mäkelä, Jaakko Kaprio, Petri Virolainen, Kari Pulkki, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkäranta, Riitta Kaarteenaho, Seppo Vainio, Miia Turpeinen, Raisa Serpi, Tarja Laitinen, Johanna Mäkelä, Veli‐Matti Kosma, Urho M. Kujala, Outi Tuovila, Minna Hendolin, Raimo Pakkanen, Jeff Waring, Bridget Riley‐Gillis, Shameek Biswas, Dorothée Diogo, Catherine Marshall, Xinli Hu, Matthias Gossel, Robert Graham, Beryl B. Cummings, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Arto Mannermaa, Jari Laukkanen, Valtteri Julkunen, Anne M. Remes, Reetta Kälviäinen, Jukka Peltola, Pentti Tienari, Juha O. Rinne, Adam Ziemann, Jeffrey F. Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenperä, Janet van Adelsberg, John A. Michon, Geoff Kerchner, Natalie Bowers, Edmond Teng, John D. Eicher, Vinay Mehta, Padhraig Gormley, Kari Linden, Christopher D. Whelan, Fanli Xu, David Pulford, Martti Färkkilâ, Sampsa Pikkarainen, Airi Jussila, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Bob Georgantas, Graham Heap, Fedik Rahimov, Keith Usiskin, Tim Lu, Danny Oh, Kirsi Kalpala, Melissa Miller, Linda McCarthy, Kari K. Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen‐Seppänen, Johanna Huhtakangas, Apinya Lertratanakul, Marla Hochfeld, Nan Bing, Jorge Esparza Gordillo, Nina Mars, Margit Pelkonen, Hannu Kankaanranta, Terttu Harju, David A. Close, Steven M. Greenberg, Hubert Chen, Jo Betts, Soumitra Ghosh, Veikko Salomaa, Teemu Niiranen, Markus Juonala, Kaj Metsärinne, Mika Kähönen, Juhani Junttila, Markku Laakso, Jussi Pihlajamäki, Juha Sinisalo, Marja‐Riitta Taskinen, Ben Challis, Andrew S. Peterson, Audrey Y. Chu, Jaakko Parkkinen, Anthony J. Muslin, Heikki Joensuu, Tuomo J Meretoja, Lauri A. Aaltonen, Johanna Mattson, Annika Auranen, Peeter Karihtala, Saila Kauppila, Päivi Auvinen, Klaus Elenius, Relja Popovic, Jennifer L. Schutzman, Andrey Loboda, Aparna Chhibber, Heli Lehtonen, Stefan McDonough, Marika Crohns, Diptee Kulkarni, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo, Vesa Aaltonen, Hannele Uusitalo‐Järvinen, Marja Luodonpää, Nina Hautala, Stephanie Loomis, Erich C. Strauss, Hao Chen, Anna Podgornaia, Joshua Hoffman, Kaisa Tasanen, Laura Huilaja, Katariina Hannula‐Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Ilkka T. Harvima, Ying Wu, David F. Choy, Pirkko J. Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Kahraman Gürsoy, Vuokko Anttonen, Kirsi Sipilä, J. Wade Davis, Danjuma Quarless, Slavé Petrovski, Eleonor Wigmore, Chia-Yen Chen, Paola G. Bronson, Ellen Tsai, Yunfeng Huang, Joseph Maranville, Elhaj Mohammed, Samir Wadhawan, Erika Kvikstad, Minal Çalışkan, Diana Chang, Tushar Bhangale, Sarah A. Pendergrass, Emily Holzinger, Xing Chen, Åsa K. Hedman, Karen S. King, Clarence Wang, Ethan Xu, Franck Augé, Clément Chatelain, Deepak K. Rajpal, Dongyu Liu, Katherine M. Call, Tai-he Xia, Matt Brauer, Mitja Kurki, Juha Karjalainen, Aki S. Havulinna, Anu Jalanko, Priit Palta, Pietro Della Briotta Parolo, Wei Zhou, Susanna Lemmelä, Manuel A. Rivas, Jarmo Harju, Arto Lehistö, Andrea Ganna, Vincent Llorens, Hannele Laivuori, Sina Rüeger, Mari Niemi, Taru Tukiainen, Mary Pat Reeve, Henrike Heyne, Kimmo Palin, Javier Gracia‐Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Amanda Elliott, Kati Kristiansson, Kati Hyvärinen, Jarmo Ritari, Miika Koskinen, Katri Pylkäs, Marita Kalaoja, Minna K. Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Eija K. Laakkonen, Csilla Sipeky, Samuel Heron, Antti Karlsson, Dhanaprakash Jambulingam, Venkat Subramaniam Rathinakannan, Risto Kajanne, Mervi Aavikko, Manuel González Jiménez, Pietro della Briotta Parola, Masahiro Kanai, Mari Kaunisto, Elina Kilpeläinen, Timo P. 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Chui, Suzanne Craft, Paul K. Crane, David H. Cribbs, Elizabeth Crocco, Carlos Cruchaga, C. Munro Cullum, Eveleen Darby, Bárbara Davis, Philip L. De Jager, Charles DeCarli, John C. DeToledo, Malcolm Dick, Dennis W. Dickson, Beth A. Dombroski, Rachelle S. Doody, Ranjan Duara, Nilüfer Ertekin‐Taner, Denis A. Evans, Thomas Fairchild, Kenneth B. Fallon, Martin R. Farlow, John J. Farrell, Victoria Fernandez-Hernandez, Steven H. Ferris, Matthew P. Frosch, Adriana C. Gamboa, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Thomas J. Grabowski, Neill R. Graff‐Radford, Struan F.A. Grant, Robert C. Green, John H. Growdon, Håkon Håkonarson, James Hall, Ronald L. Hamilton, Oscar Harari, Lindy E. Harrell, Jacob Haut, Elizabeth Head, Victor W. Henderson, Michelle L. Hernandez, Timothy J. Hohman, Lawrence S. Honig, Ryan Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibáñez, Gail P. Jarvik, Suman Jayadev, Lee‐Way Jin, Kim G. Johnson, Leigh A. Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, C. Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Frank M. LaFerla, James J. Lah, Eric B. Larson, Edward B. Lee, Alan J. Lerner, Yuk Yee Leung, James B. Leverenz, Allan I. Levey, Mingyao Li, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Constantine G. Lyketsos, John Malamon, Douglas Mains, Daniel Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul J. Massman, Arjun V. Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Jesse Mez, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. Morris, Amanda Myers, Trung Nguyen, Sid E. O’Bryant, John Olichney, Marcia G. Ory, Raymond F. Palmer, Joseph E. Parisi, Henry L. Paulson, Valory Pavlik, David Paydarfar, Victòria Aurora Ferrer Pérez, Elaine R. Peskind, Ronald C. Petersen, Jennifer E. Phillips‐Cremins, Aimee Pierce, Marsha J. Polk, Wayne W. Poon, Huntington Potter, Liming Qu, Mary Quiceno, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Eric M. Reiman, Barry Reisberg, Joan Reisch, John M. Ringman, Erik D. Roberson, Monica Rodriguear, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Donald R. Royall, Mark A. Sager, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Susan H. Slifer, Scott A. Small, Amanda Smith, Janet P. Smith, Joshua A. Sonnen, Salvatore Spina, Peter St George‐Hyslop, Robert A. Stern, Alan Stevens, Stephen M. Strittmatter, David L. Sultzer, Russell H. Swerdlow, Rudolph E. Tanzi, Jeffrey L. Tilson, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Robert Vassar, Harry V. Vinters, Jean‐Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Patrice L. Whitehead, Ellen M. Wijsman, Kirk C. Wilhelmsen, Benjamin Williams, Jennifer Williamson, Henrik Wilms, Thomas S. Wingo, Thomas Wısnıewskı, Randall L. Woltjer, Martin Woon, Clinton B. Wright, Chuang‐Kuo Wu, Steven G. Younkin, Chang‐En Yu, Lei Yu, Yuanchao Zhang, Xiongwei Zhu, Hieab H.H. Adams, Rufus Akinyemi, Muhammad Ali, Hugo J. Aparicio, Maryam Bahadori, Monique M.B. Breteler, Daniel I. Chasman, Ganesh Chauhan, Hata Comic, Simon R. Cox, L. Adrienne Cupples, Gail Davies, Charles DeCarli, Marie-Gabrielle Duperron, Josée Dupuis, Tavia E. Evans, Frank Fan, Annette L. Fitzpatrick, Alison E. Fohner, Mary Ganguli, Mirjam I. Geerlings, Stephen J. Glatt, Héctor M. González, Monica Goss, Hans J. Grabe, Mohamad Habes, Susan R. Heckbert, Edith Hofer, Elliot Hong, Timothy M. Hughes, Tiffany F. Kautz, Maria J. Knol, William S. Kremen, Paul Lacaze, Jari Lahti, Quentin Le Grand, Elizabeth Litkowski, Shuo Li, Dan Liu, Xuan Liu, Marisa Loitfelder, Alisa K. Manning, Pauline Maillard, Riccardo E. Marioni, Bernard Mazoyer, Debora Melo van Lent, Hao Mei, Aniket Mishra, Paul Nyquist, Jeffrey R. O’Connell, Yash Patel, Tomáš Paus, Zdenka Pausová, Katri Raikkonen-Talvitie, Moeen Riaz, Stephen S. Rich, Jerome I. Rotter, José R. Romero, Gena Roshchupkin, Yasaman Saba, Muralidharan Sargurupremraj, Helena Schmidt, Reinhold Schmidt, Joshua Shulman, Jennifer A. Smith, Hema Sekhar, Reddy Rajula, Jean Shin, Jeannette Simino, Eeva Sliz, Alexander Teumer, Alvin G. Thomas, Adrienne Tin, Elliot M. Tucker–Drob, Dina Vojinović, Yanbing Wang, Galit Weinstein, Dylan M. Williams, Katharina Wittfeld, Lisa R. Yanek, Yunju Yang, Lindsay A. Farrer, Bruce M. Psaty, Mohsen Ghanbari, Towfique Raj, Perminder S. Sachdev, Karen A. Mather, Frank Jessen, M. Arfan Ikram, Alexandre de Mendonça, Jakub Hort, Magda Tsolaki, Margaret A. Pericak‐Vance, Philippe Amouyel, Julie Williams, Ruth Frikke‐Schmidt, Jordi Clarimón, Jean‐François Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustı́n Ruiz, Alfredo Ramı́rez, Jean‐Charles Lambert
2595Citations signalées — pas une note de qualité
362Institutions déclarées
26Pays d’affiliation déclarés
Résumé fourni par la source
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Date Crossref
- 01/04/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
InsermUniversité de LilleInstitut Pasteur de LilleCentre Hospitalier Universitaire de LilleFacteurs de risque et déterminants moléculaires des maladies liées au vieillissementUniversity of AntwerpVIB-UAntwerp Center for Molecular NeurologyAmsterdam NeuroscienceAmsterdam University Medical CentersVrije Universiteit AmsterdamUniversity of CologneUniversity Hospital BonnGerman Center for Neurodegenerative DiseasesInstituto de Salud Carlos IIIBiomedical Research Networking Center on Neurodegenerative DiseasesFundació ACEErasmus MCUniversity of OxfordErasmus University RotterdamUniversity of PennsylvaniaCardiff UniversityCommissariat à l'Énergie Atomique et aux Énergies AlternativesUniversité Paris-SaclayCentre National de Recherche en Génomique HumaineCEA Paris-SaclayUniversidade Federal do Rio Grande do NorteUniversity of Eastern FinlandBoston UniversityUniversity of WashingtonLeiden University Medical CenterUppsala UniversityStavanger University HospitalUniversidad de MálagaUniversitat Autònoma de BarcelonaHospital de Sant PauUniversity Hospital Mútua de TerrassaMútua TerrassaInstituto de Investigación Biosanitaria de GranadaHospital Universitario Central de AsturiasInstituto de Investigación Sanitaria del Principado de AsturiasUNSW SydneyCentre for Healthy Brain AgeingAristotle University of ThessalonikiGreek Association of Alzheimer's Disease and Related DisordersHospital Universitario Virgen de la ArrixacaAzienda Ospedaliera San GerardoUniversity of Milano-BicoccaFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoUniversity of BresciaHospital Universitari de Santa MariaInstituto de Investigación Biomédica de LleidaFundacion Centro De Investigacion De Enfermedades NeurologicasUniversity of MilanUniversity of OsloUniversité Paris CitéAssistance Publique – Hôpitaux de ParisHôpital BrocaMaladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologieFondazione Santa LuciaHospital Universitari i Politècnic La FeUniversity of ParmaMedical University of SofiaColumbia UniversityFramingham Heart StudyVanderbilt UniversityVanderbilt HealthThe University of Texas Health Science Center at HoustonCase Western Reserve UniversityCentro San Giovanni di Dio FatebenefratelliUniversité de MontpellierNeuropsychiatrie : Recherche Epidemiologique et CliniqueAzienda Ospedaliero-Universitaria CareggiUniversity of FlorenceAgostino Gemelli University PolyclinicIstituti di Ricovero e Cura a Carattere ScientificoBaylor College of MedicineUniversity of TurinNorwegian University of Science and TechnologySt Olav's University HospitalDementia Collaborative Research CentresNottingham Trent UniversityUniversidad de Buenos AiresInstitut für Schlaganfall- und DemenzforschungLudwig-Maximilians-Universität MünchenUniversity of AucklandUnidad Funcional de Investigación de Enfermedades CrónicasUniversité de BordeauxCentre Hospitalier Universitaire de BordeauxBordeaux Population HealthCentre d'Investigation Clinique Plurithématique de BordeauxUniversity of MiamiDr. John T. Macdonald FoundationUniversidade de Santiago de CompostelaFundación Pública Galega de Medicina XenómicaUniversity of PerugiaNormandie UniversitéGénomique du cancer et du cerveauUniversité de Rouen NormandieUniversity of CagliariRadboud University NijmegenRadboud University Medical CenterUniversity of ZurichHospital Universitario de ValmeUniversity of Bari Aldo MoroUniversity of ThessalyUniversity Medical Center GroningenIcahn School of Medicine at Mount SinaiMunich Cluster for Systems NeurologyTUM KlinikumTechnical University of MunichIcelandic Heart AssociationVrije Universiteit BrusselUniversitair Ziekenhuis BrusselIndiana University – Purdue University IndianapolisFondazione IRCCS Istituto Neurologico Carlo BestaGentofte HospitalUniversity of KentuckyTexas Tech UniversityUniversity College LondonTexas Tech University Health Sciences CenterUniversity of LisbonDonauspitalThe University of Texas at San Antonio Health Science CenterInstitute for Neurodegenerative DisordersUK Dementia Research InstituteNational Hospital for Neurology and NeurosurgeryInstituto de Biomedicina de SevillaHospital Universitario Virgen del RocíoUniversidad de SevillaHospital La Paz Institute for Health ResearchCentro de Biología Molecular Severo OchoaUniversidad Autónoma de MadridHospital Universitario La PazHeidelberg UniversityCentral Institute of Mental HealthInstituto Ramón y Cajal de Investigación SanitariaHospital Universitario Ramón y CajalMedical University of ViennaCentro Andaluz de Biología del DesarrolloKarolinska University HospitalKarolinska InstitutetStockholm UniversityUniversity of CambridgeETH ZurichUniversity Hospital ZurichSwiss Integrative Center for Human HealthUniversity of IcelandUniversity of NottinghamUniversity of CyprusSorbonne UniversitéPitié-Salpêtrière HospitalAlzheimer Precision MedicineUniversity of BonnUniversity of SouthamptonAllen Institute for Brain ScienceUniversity Medical Center UtrechtBrigham Young UniversityUniversity of BristolHässleholms SjukhusImperial College LondonUniversity of HelsinkiHelsinki University HospitalKuopio University HospitalFriedrich-Alexander-Universität Erlangen-NürnbergUniversitätsklinikum ErlangenUniversidad de CantabriaMarqués de Valdecilla University HospitalInstituto de Investigación Marqués de ValdecillaStockholm Gerontology Research Center FoundationNational Institutes of HealthInstitute on AgingNational Institute on AgingFinnish Institute for Health and WelfareCharles UniversityUniversity Hospital BrnoSt. Anne's University Hospital BrnoBiogipuzkoa Health Research InstituteBangor UniversityUniversità Cattolica del Sacro CuoreMRC Prion UnitUniversity of Duisburg-EssenHospital Clínic de BarcelonaBanc de Sang i TeixitsConsorci Institut D'Investigacions Biomediques August Pi I SunyerConsejo Nacional de Investigaciones Científicas y TécnicasUniversity of Mississippi Medical CenterInstitute for Medical ResearchDon Carlo Gnocchi FoundationUniversity of CopenhagenInstituto de Biomedicina de ValenciaInstituto de Investigación Sanitaria La FeCentre National de la Recherche ScientifiqueFreie Universität BerlinCharité - Universitätsmedizin BerlinHôpital Orthopédique de la Suisse RomandeUniversity of LausanneRigshospitaletMaastricht UniversityDelft University of TechnologyLeipzig UniversityUniversitätsklinikum WürzburgPrivatsykehuset HaugesundFonna Hospital TrustUniversity of BergenAzienda Ospedaliera Citta' della Salute e della Scienza di TorinoHospital Universitario de Gran Canaria Doctor NegrínUniversitat de BarcelonaNational and Kapodistrian University of AthensEginition HospitalUniversität HamburgUniversity Medical Center Hamburg-EppendorfZimmer Biomet (Germany)Oslo University HospitalOspedale Vito FazziHospital Clínico San CarlosCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas AsociadasNamsos HospitalKU LeuvenHarvard UniversityMcLean HospitalHarokopio University of AthensNa Homolce HospitalUniversity of OuluKing's College LondonQueen's Medical CentreQueen's University BelfastWellcome Sanger InstituteSt. James's HospitalDublin City UniversityQIMR Berghofer Medical Research InstituteManchester Academic Health Science CentreUniversity of ManchesterJohn Radcliffe HospitalHospital Clínico Universitario de ValenciaHertie Institute for Clinical Brain ResearchHospital El CruceHospital Privado de ComunidadUniversidad Nacional de La PampaInstituto de Neurología CognitivaHospital Universitario Son EspasesUniversity of the Basque CountryFundacion CITA AlzheimerNavarrabiomedHospital Universitario de La PrincesaStructure et Instabilité des GénomesInstitut de Psychiatrie et Neurosciences de ParisInstitut du CerveauNewcastle Hospitals - Campus for Ageing and VitalityNewcastle UniversityInstitut für Medizinische Biometrie, Informatik und EpidemiologieSomerset Partnership NHS Foundation TrustUniversity Hospital of WalesHelmholtz MunichSaarland UniversityUniversity of FreiburgUniversity Hospital HeidelbergAkershus University HospitalInnlandet Hospital TrustInstitute for Molecular Medicine FinlandAbbVie (United States)AstraZeneca (United Kingdom)Biogen (United States)GlaxoSmithKline (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)Pfizer (United States)Sanofi (France)Maze (United States)Janssen (Belgium)University of TurkuTurku University HospitalVarsinais-Suomen SairaanhoitopiiriFinnish Red CrossHospital District of Helsinki and UusimaaBorealis (Finland)Northern Ostrobothnia Hospital DistrictTampere UniversityPirkanmaa Hospital DistrictTampere UniversityFinland UniversityCentral Finland Health Care DistrictUniversity of JyväskyläBusiness FinlandBristol-Myers Squibb (United States)Broad InstituteStanford UniversityThe University of Texas Southwestern Medical CenterThe University of Texas at AustinJohns Hopkins UniversityUniversity of MichiganMichigan MedicineMayo Clinic in FloridaUniversity of North TexasUniversity of North Texas Health Science CenterIndiana University School of MedicineUniversity of Wisconsin–MadisonGeriatric Research Education and Clinical CenterRush University Medical CenterBanner Sun Health Research InstituteUniversity of PittsburghHope Center for Neurological DisordersNorthwestern UniversityVA Puget Sound Health Care SystemMayo Clinic in ArizonaSwedish Medical CenterUniversity of California, San FranciscoUniversity of California San DiegoDuke UniversityUniversity of Kansas Medical CenterWashington University in St. LouisUniversity of South FloridaUSF Health Byrd Alzheimer's InstituteFred Hutch Cancer CenterBruce W. Carter VA Medical CenterUniversity of North Carolina at Chapel HillUniversity of California, Los AngelesUniversity of Southern CaliforniaWake Forest UniversityUniversity of California, IrvineColumbia University Irving Medical CenterUniversity of California, DavisMount Sinai Medical CenterUniversity of Alabama at BirminghamNew York UniversityMassachusetts General HospitalEmory HealthcareEmory UniversityWinnMedChildren's Hospital of PhiladelphiaBrigham and Women's HospitalVanderbilt University Medical CenterTranslational Genomics Research InstituteAlbert Einstein College of MedicineOregon Health & Science UniversityPortland VA Medical CenterKaiser Permanente Washington Health Research InstituteCleveland ClinicLou Ruvo Brain InstituteNational Center for PTSDUniversity of Colorado DenverUniversity of TorontoOccupational Cancer Research CentreYale UniversityRenaissance Computing InstituteCurtin UniversityUniversity of EdinburghSUNY Upstate Medical UniversityUniversitätsmedizin GreifswaldMedical University of GrazUniversity of Maryland, College ParkMonash UniversityUniversity of Colorado AnschutzInstitut des Maladies NeurodégénérativesJackson Memorial HospitalJohns Hopkins MedicineCentre Hospitalier Universitaire Sainte-JustineUniversité de MontréalHospital for Sick ChildrenSickKids FoundationThe Lundquist InstituteHarbor–UCLA Medical CenterBoston Medical CenterCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Une affiliation ne permet pas de déduire la nationalité d’un auteur.
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