Carolina Cuesta

Beginning Literacy as the Object of Study of Language and Literature Teaching Research, from an Ethnographic Perspective: Contributions to Teacher Training and the Teaching Work

Carolina Cuesta

This article presents the concepts and fundamentals of the lines of research on Language and Literature teaching from an ethnographic perspective, which we have been conducting in Argentina. Currently, these lines of research are being carried out at Universidad Pedagógica Nacional and …

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Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte et autres

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed …

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Prospective memory in patients with Mild Cogntive Impairment

Carolina Cuesta, Evangelina-Valeria Cores, Magalí Rivara, Lucía Soccini et autres

Prospective memory is the ability to remember to carry out intended actions and to evoke delayed intentions. It constitutes a crucial skill for the daily functioning of the elderly. It might also be prematurely compromised in neurodegenerative diseases. In the Latin American …

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Cuestionario de Reserva Cognitiva--Adaptación Argentina

Carolina Cuesta, Florencia Carla Cossini, Daniel Gustavo Politis

Adaptación argentina del Cuestionario de Reserva Cognitiva: CRC-a

Carolina Cuesta, Florencia Carla Cossini, Daniel Gustavo Politis

Cognitive reserve (CR) refers to the level of adaptability of cognition after brain changes. It is based on processes that allow the activation of new synaptic connections after neurodegeneration, which permits to better withstand the consequences. This reserve is constituted by the …

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Tracking the impact of multiple sclerosis on employment status: the development of a questionnaire

Evangelina Valeria Cores, Judith Steinberg, Carolina Cuesta, María Celeste Curbelo et autres

BACKGROUND: Multiple sclerosis (MS) has a negative effect on employment status. OBJECTIVE: To present the preliminary results of a special questionnaire designed to collect employment information on patients with MS. METHODS: The questionnaire on the impact of MS on employment status was …

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New insights into the genetic etiology of Alzheimer’s disease and related dementias

Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam et autres

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. …

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Tracking MS Impact on Work Status Questionnaire

Evangelina Valeria Cores, Judith Steinberg, Carolina Cuesta, María Celeste Curbelo et autres