Ashok B Raj

Infantile Hepatic Hemangiomas and Hemoglobin SC Disease in a Very Low Birth Weight Premature Infant with Pulmonary Hypertension and Congestive Heart Failure: A Case of Multifactorial Etiology

Kassidi Napier, Kerry McGowan, Jamie C Morris, Ashok B Raj

Infantile hepatic hemangiomas (IHHs) are common benign tumors in infants that may have an amplifying effect leading to significant complications, particularly in the context of extreme prematurity.We are reporting a case of a 9-month-old female infant with multiple IHHs, birth weight 700 …

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Enhancing Impact: The Use of VA-ECMO in a Critically Ill Pediatric Patient with Sickle Cell Disease, Acute Chest Syndrome, and Streptococcal Toxic Shock Syndrome

Tiffany Brooks, Ashok B Raj

Streptococcal toxic shock syndrome (STSS) and acute chest syndrome (ACS) present significant challenges in managing pediatric patients with sickle cell disease (SCD).A patient with SCD developed severe STSS and ACS, necessitating advanced interventions due to rapid clinical deterioration.Initial treatments included broad-spectrum antibiotics …

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Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions

Brandon-Joe Cilia, James Haridy, Ashok B Raj, Nicholas Hannah

Hepatic hydrothorax (HH) is an uncommon yet severe manifestation of portal hypertension which develops in 5%-10% of patients with liver cirrhosis. It typically presents as a unilateral, right-sided pleural effusion and in the context of end-stage liver disease and concomitant ascites. The …

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Improving Glioblastoma Radiotherapy Target Delineation via a Diffusion Model

Woon‐Hong Yeo, Sairaman Nagarajan, Ashok B Raj, Dan Ruan et autres

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Abstract Fri012: Dual CXCR4/CXCR7 Modulation: TC14012 as a Novel Therapeutic Strategy Against Doxorubicin-Induced Cardiotoxicity

Xiaodan Hui, Chunjie Gu, Ahmed Abdelbaset‐Ismail, Jianxiang Xu et autres

Background: Doxorubicin (DOX) is an effective chemotherapy but limited by severe cardiotoxicity. Chemokine receptors CXCR4 and CXCR7 are involved in regulating cardiac survival, inflammation, and fibrosis, yet their specific roles in DOX-induced cardiotoxicity (DICT) remain unclear. Objective: We investigated the cardioprotective effects …

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Grandchildren of GRNDaD : Shifts in disease‐modifying therapy at the adolescent transition in sickle cell disease

Matthew Chang, Daniel Semakula, Jane Alison Little, Julie Kanter et autres

Characterizing the modern person living with sickle cell disease (SCD) in the United States has been limited without a well-curated longitudinal registry. To address this, the Globin Research Network for Data and Discovery (GRNDaD) registry strives to collect clinical outcomes and quality …

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease

Farid Rajabli, Penelope H. Benchek, Giuseppe Tosto, Nicholas A. Kushch et autres

BACKGROUND: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We construct and analyze a multi-ancestry GWAS dataset in the Alzheimer's Disease Genetics Consortium (ADGC) …

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WED-424 Fibroscan-based screening to determine the prevalence and severity of steatotic liver disease in type 1 diabetes – an australian quantentary centre experience

Janakan Selvarajah, Omar Salehi, Christine Y. Lu, Faris Gondal et autres

Proton pump inhibitors in cirrhosis: a retrospective five-year analysis of increased risks of hepatic decompensation and infections

Abhimati Ravikulan, NH Russell, Christin Coomarasamy, Ashok B Raj

AIM: Proton pump inhibitors (PPIs) are widely used in cirrhotic patients, often without a clear indication. Evidence links PPI use to adverse outcomes such as hepatic encephalopathy and spontaneous bacterial peritonitis. This study analyses outcomes associated with PPI use in cirrhosis over …

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Maximizing Survival: VA-ECMO As a Lifeline in a Critically Ill Pediatric Patient with Sickle Cell Disease, Acute Chest Syndrome, and Streptococcal Toxic Shock Syndrome

Ashok B Raj, Tiffany Brooks

Streptococcal toxic shock syndrome (STSS) is a rapid-onset medical crisis marked by refractory shock and multi-organ failure, with a high mortality rate. This condition often leads to death shortly after symptom onset. In patients with sickle cell disease (SCD), the simultaneous occurrence …

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Giving the Green Light for Transfer to Adult Care: One Center's Interdisciplinary Approach

Spencer Moorman, Ashok B Raj

Background: Many strides have been made in the transition of care from pediatrics to adult care for patients with sickle cell disease.1 Understandably, efforts have been made to garner feedback from patients to determine which issues are important to them to address …

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Abstract We097: Dual Targeting CXCR4 and CXCR7 Prevents Doxorubicin-Induced Cardiotoxicity by Eliminating Cardiac Inflammation and Preserving Cardiomyocyte Function

Xiaodan Hui, Chunjie Gu, Ahmed Abdelbaset‐Ismail, Jianxiang Xu et autres

Background: Doxorubicin (DOX)-induced cardiotoxicity (DICT) has become a serious health burden for cancer survivors. The detrimental effects of CXCR4-mediated excessive inflammation in myocardium and the protective effects of CXCR7 in cardiomyocytes have been demonstrated. Aims: We tested the protective effects against DICT …

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