Jaakko Kaprio

Genome-wide association meta-analysis of eating behavior traits revealed one susceptibility locus for emotional eating

Manon Muntaner, Katrin Horn, Blandine de Lauzon‐Guillain, Muriel Tafflet et autres

In order to identify new and genome-wide significant loci for eating behavior traits (cognitive restraint, uncontrolled eating and emotional eating), we conducted a meta-GWAS with seven studies of European ancestry ( n = 11,250). Eating behavior was assessed using the Three-Factor Eating …

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Prehospital death in aneurysmal subarachnoid haemorrhage. A systematic review and meta-analysis of population-based studies

Aleksanteri Asikainen, Ilari Rautalin, Jaakko Kaprio, Miikka Korja

A substantial share of people with aneurysmal subarachnoid haemorrhage (SAH) die before they reach hospital. These deaths are absent from hospital series and from treatment trials, so estimates of how lethal SAH is, and of how much survival has improved, rest on …

Robust inference and correlates from genetic associations with personality

Ted Schwaba, Margaret L. Clapp Sullivan, Wonuola A. Akingbuwa, Kerli Ilves et autres

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, their generalizability and …

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Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes

Jet D. Termorshuizen, Helena L. Davies, Sang Hyuck Lee, Jessica K. Dennis et autres

Eating disorders-including anorexia nervosa (AN), bulimia nervosa and binge-eating disorder-are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. Here we conducted a genomic meta-analysis of case-control studies of binge-eating behavior (BE; 39,279 cases, 1,227,436 controls), …

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The BEAC, an epigenetic clock for birds

Mikaela Hukkanen, Simon Jarman, Alyssa M. Budd, Flávia A. N. Fernandes et autres

Abstract Epigenetic clocks are powerful tools for estimating both chronological and biological age, enabling the integration of age information into population monitoring, demographic modelling, and research on the ecophysiology and evolution of ageing. Most epigenetic clocks so far have been developed for …

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Meta-analysis of genome-wide association studies of alexithymia across multiple cohorts

Zoe Reed, Nurul Hanis Ramzi, Hélio Clemente Cuve, Amanda Hughes et autres

The aim of this study is to conduct a large meta-GWAS of alexithymia using the 20-item Toronto Alexithymia Scale (TAS-20) score across a range of cohorts with available data. By doing so, we aim to identify additional single nucleotide polymorphisms (SNPs) associated …

Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort study

Niko Paavo Tynkkynen, Laura Joensuu, Päivi Herranen, Jaakko Kaprio et autres

We examined whether a genome-wide polygenic lifespan score (PLS) is associated with all-cause mortality and how this association compares with associations between long-term lifestyle factors and mortality. The PLS was computed for the older Finnish Twin Cohort (mean age 57.4 years; 45.2% …

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Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders

Fabian Streit, Swapnil Awasthi, Alisha S. M. Hall, Alice Braun et autres

Borderline personality disorder (BPD) is a severe mental health condition influenced by environmental risk factors (for example, interpersonal trauma) and genetic factors. We conducted the largest genome-wide association study (GWAS) meta-analysis of BPD so far, with a discovery sample of 12,339 cases …

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Epigenome-wide association study meta-analysis of wellbeing

Meike Bartels, Margot P. van de Weijer, Natalia Azcona-Granada, Bart M. L. Baselmans et autres

Wellbeing is associated with both behavioral phenotypes as well as several key life outcomes, such as health, employment, and coping with stressful events. These phenotypes associated with wellbeing could be potential indicators of differential epigenetic patterns between individuals that differ in their …

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CYP2D6 Metabolizer Phenotype Is Associated with Early Antidepressant Discontinuation in the UK Biobank

Tehila Cohen, Estee Rebibo Demry, A H Young, K. Kleine Schaars et autres

Background/Objectives: Antidepressant treatment response is highly variable, and CYP2D6 metabolizer phenotype has been proposed as a contributor to this variability. It was examined whether CYP2D6 metabolizer phenotype is associated with real-world antidepressant treatment outcomes in a large population-based cohort. Methods: Using genetic …

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Genetic and Shared Environmental Influences on Cancer Risk and Cross-Cancer Associations in Nordic Twins

Jennifer R. Harris, Signe Bedsted Clemmensen, Hans‐Olov Adami, Lorelei A. Mucci et autres

ABSTRACT The relative contributions of genetic and shared environmental influences to cancer risk and cross-cancer associations remain poorly understood. We analyzed data from 222,530 same-sex twins from Denmark, Finland, Norway, and Sweden in the Nordic Twin Study of Cancer, including 43,060 incident …

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Exercise Training Improves Skeletal Muscle Insulin Sensitivity and Reprograms the Adipose Transcriptome in Heavier Monozygotic Twins

Jaakko Hentilä, Max Ullrich, Ronja Ojala, Martin S. Lietzén et autres

Exercise training improves skeletal muscle insulin sensitivity, yet its effects on white adipose tissue remain incompletely understood. We investigated how adiposity and exercise training influence insulin-stimulated glucose uptake in skeletal muscle and abdominal subcutaneous adipose tissue (ASAT), alongside adaptations in gene expression …

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