Ildebrando Appollonio

Gray matter atrophy and structural connectivity in Posterior Cortical Atrophy: A voxel-based meta-analysis

Daniele Licciardo, Chiara Matti, Alberto Benelli, Isella et autres

Posterior Cortical Atrophy (PCA) is a neurodegenerative syndrome most commonly associated with Alzheimer's disease, characterized by progressive visuospatial and visuoperceptual decline. Although voxel-based morphometry studies have described gray matter loss in PCA, a comprehensive and updated coordinate-based meta-analysis is still missing, and …

us, ch, it (code pays fourni par la source)

Cognitive and social intervention with Go and chess in early and subjective cognitive decline: The COGniChESs study results, with an updated meta-analysis

Federico Emanuele Pozzi, Alessandro Spanio, Francesco Gallo, G. Isgro et autres

Background There is a growing interest in dementia prevention and scalable cognitive enhancement strategies for individuals at-risk, with or without Alzheimer's disease. Board games have shown potential cognitive and mood benefits, but randomized controlled evidence remains limited and heterogeneous. Objective We aimed …

it (code pays fourni par la source)

Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program

Chukwuma Okoye, Luca Cuffaro, Federico Emanuele Pozzi, Maria Cristina Ferrara et autres

OBJECTIVES: Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings. METHODS: Spoke …

it, ca (code pays fourni par la source)

Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants

Edoardo Gioele Spinelli, Francesca Orlandi, Silvia Basaia, Francesco Costa et autres

BACKGROUND: Frontotemporal dementia (FTD) encompasses diverse clinical phenotypes, primarily characterized by behavioral and/or language dysfunction. A newly characterized variant, semantic behavioral variant FTD (sbvFTD), exhibits predominant right temporal atrophy with features bridging behavioral variant FTD (bvFTD) and semantic variant primary progressive aphasia …

it (code pays fourni par la source)

The Brain Functional Neural Organisation of Apathy and Depression in Amyotrophic Lateral Sclerosis: A Connectome-Based Study

Veronica Castelnovo, Elisa Canu, Silvia Basaia, Edoardo Gioele Spinelli et autres

it (code pays fourni par la source)

Machine learning in Alzheimer’s disease genetics

Matthew Bracher‐Smith, Federico Melograna, Brittany Ulm, Céline Bellenguez et autres

Traditional statistical approaches have advanced our understanding of the genetics of complex diseases, yet are limited to linear additive models. Here we applied machine learning (ML) to genome-wide data from 41,686 individuals in the largest European consortium on Alzheimer's disease (AD) to …

gb, be, us, ca, fr, nl, es, ar, de, at, gr, fi, pt, bg, cz, dk, se, ch, it, Tunisie, no (code pays fourni par la source)

Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression

Veronica Castelnovo, Elisa Canu, Silvia Basaia, Edoardo Gioele Spinelli et autres

BACKGROUND: Apathy and depression are the most prevalent neuropsychiatric symptoms in amyotrophic lateral sclerosis (ALS). Although insufficiently investigated, their distinction holds important clinical relevance for accurate diagnosis of ALS with behavioural impairment and for patients' prognosis and management. In the present study, …

it (code pays fourni par la source)

Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study

Federico Emanuele Pozzi, Anna Falco, Giuseppe Fiamingo, Giulia Remoli et autres

Abstract Aim Neurological soft signs (NSSs) encompass subtle neurological abnormalities, often indicative of impaired motor and sensory integration, observed in various neuropsychiatric conditions. NSSs have been recently investigated as potential diagnostic markers in neurodegenerative dementias. We aimed to confirm an NSS increase …

it (code pays fourni par la source)

Distinctive Brain Atrophy Progression Patterns Aid Classification of Frontotemporal Dementia Variants (P4-3.011)

Edoardo Gioele Spinelli, Francesca Orlandi, Silvia Basaia, Francesco Costa et autres

To describe longitudinal structural MRI correlates of clinically overlapping frontotemporal dementia (FTD) variants, describing their patterns of cortical and subcortical atrophy and assessing their utility for differential diagnosis and prognosis.

it, fr, us (code pays fourni par la source)

Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review

G Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti et autres

Introduction: Behavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course of dementia and impact caregiving. Among these, the Hyperactivity-Impulsivity-Irritiability-Disinhibition-Aggression-Agitation (HIDA) and Psychosis (P) domains are particularly challenging to manage. Despite their prevalence, their underlying mechanisms …

it (code pays fourni par la source)

Core blood biomarkers of Alzheimer's disease: A single-center real-world performance study

Federico Emanuele Pozzi, Elisa Conti, Giulia Remoli, Niccolò dell'Orto et autres

BACKGROUND: The new criteria for Alzheimer's disease pave the way for the introduction of core blood biomarkers of Alzheimer's disease (BBAD) into clinical practice. However, this depends on the demonstration of sufficient accuracy and robustness of BBADs in the intended population. OBJECTIVES: …

it (code pays fourni par la source)

Frontotemporal dementia characterization using neurite orientation dispersion and density imaging

Stefano Pisano, Silvia Basaia, Federica Agosta, Elisa Canu et autres

Microstructural alterations in brain tissue play a crucial role in the pathophysiology of frontotemporal dementia (FTD). This study assessed brain white matter (WM) and grey-matter (GM) microstructure in FTD variants using neurite orientation dispersion and density imaging (NODDI) diffusion MRI model and …

it, Afrique du Sud (code pays fourni par la source)