Carsten Künne

Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory

Luis Daniel Hernandez Torres, Flávia Rezende, Eva Peschke, Olga Will et autres

Introduction The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice. Methods We induced atherosclerosis in male C57BL/6N mice by injecting AAV-PCSK9DY (2x1011 VG) and …

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Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Verawan Boonsanay, Mohammed H. Mosa, Mario Looso, Dieter Weichenhan et autres

BACKGROUND & AIMS: Epigenetic processes regulating gene expression contribute markedly to epithelial cell plasticity in colorectal carcinogenesis. The lysine methyltransferase SUV420H2 comprises an important regulator of epithelial plasticity and is primarily responsible for trimethylation of H4K20 (H4K20me3). Loss of H4K20me3 has been …

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Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells

Carsten Künne, Dong Ding, Stefan Günther, Xinyue Guo et autres

Transcription replication collisions (TRCs) constitute a major intrinsic source of genome instability but conclusive evidence for a causal role of TRCs in tumor initiation is missing. We discover that lack of the H4K20-dimethyltransferase KMT5B (also known as SUV4-20H1) in muscle stem cells …

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Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression

Angelina M. Georgieva, Xinyue Guo, Marek Bartkuhn, Stefan Günther et autres

-dependent SIRT1-7 family of protein deacetylases plays a vital role in various molecular pathways related to stress response, DNA repair, aging and metabolism. Increased activity of individual sirtuins often exerts beneficial effects in pathophysiological conditions whereas reduced activity is usually associated with …

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Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilić et autres

Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a …

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Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

András Iring, Young‐June Jin, Julián Albarrán-Juárez, Mauro Siragusa et autres

Hypertension is a primary risk factor for cardiovascular diseases including myocardial infarction and stroke. Major determinants of blood pressure are vasodilatory factors such as nitric oxide (NO) released from the endothelium under the influence of fluid shear stress exerted by the flowing …

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Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples – a proof-of-principle assessment

Hagen Frickmann, Carsten Künne, Ralf Matthias Hagen, Andreas Podbielski et autres

BACKGROUND: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis …

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Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

Jens Preussner, Jiasheng Zhong, Krishnamoorthy Sreenivasan, Stefan Günther et autres

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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

Matthias S. Leisegang, Christian Fork, Ivana Josipovic, Florian Martin Richter et autres

Background: The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. Methods: Epigenetically controlled lncRNAs in human umbilical …

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LncRNA MANTIS facilitates endothelial angiogenic function

Matthias S. Leisegang, Christian Fork, Ivana Josipovic, F. Richler et autres

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LSC Abstract – Epigenome-wide mapping of histone modification landscape in human pulmonary arterial hypertension

Prakash Chelladurai, Swati Dabral, Carsten Künne, Shobha Rani Basineni et autres

Genome-wide alteration in the epigenetic regulatory network that facilitates normal cells to acquire pro-proliferative, pro-inflammatory phenotype remains unexplored in pulmonary arterial hypertension (PAH). Our objective is to employ next generation sequencing (NGS) approaches to identify disease-specific epigenetic signatures in idiopathic PAH (IPAH). …

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LSC Abstract – Epigenome-wide mapping of histone modification landscape in human pulmonary arterial hypertension

Prakash Chelladurai, Swati Dabral, Carsten Künne, Shobha Rani Basineni et autres

Genome-wide alteration in the epigenetic regulatory network that facilitates normal cells to acquire pro-proliferative, pro-inflammatory phenotype remains unexplored in pulmonary arterial hypertension (PAH). Our objective is to employ next generation sequencing (NGS) approaches to identify disease-specific epigenetic signatures in idiopathic PAH (IPAH). …

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