Ivana Josipovic

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion

Florian Jürgen Raimann, Stefan Dröse, Erik Bonke, Lea Schneider et autres

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Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli et autres

Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene network regulating serine-glycine metabolism with the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) as a causal regulator using integrative network modeling and Bayesian network analysis in human aortic endothelial …

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Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function

Ivana Josipovic, Beatrice Pflüger, Christian Fork, Andrea E Vasconez et autres

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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

Matthias S. Leisegang, Christian Fork, Ivana Josipovic, Florian Martin Richter et autres

Background: The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. Methods: Epigenetically controlled lncRNAs in human umbilical …

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LncRNA MANTIS facilitates endothelial angiogenic function

Matthias S. Leisegang, Christian Fork, Ivana Josipovic, F. Richler et autres

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CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

Kim-Kristin Prior, Matthias S. Leisegang, Ivana Josipovic, Oliver Löwe et autres

The NADPH oxidases are important transmembrane proteins producing reactive oxygen species (ROS). Within the Nox family, different modes of activation can be discriminated. Nox1-3 are dependent on different cytosolic subunits, Nox4 seems to be constitutively active and Nox5 is directly activated by …

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The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype

Ralf Peter Brandes, Sabine Harenkamp, Christoph Schürmann, Ivana Josipovic et autres

OBJECTIVE: Reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidases contribute to angiogenesis and vascular repair. NADPH oxidase organizer 1 (NoxO1) is a cytosolic protein facilitating assembly of constitutively active NADPH oxidases. We speculate that NoxO1 also contributes to basal …

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PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells

Ivana Josipovic, Christian Fork, Jens Preussner, K‐K. Prior et autres

AIM: Platelet-activating factor acetyl hydrolase 1B1 (PAFAH1B1, also known as Lis1) is a protein essentially involved in neurogenesis and mostly studied in the nervous system. As we observed a significant expression of PAFAH1B1 in the vascular system, we hypothesized that PAFAH1B1 is …

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PAFAH1B1 is important for endothelial cell angiogenic function

Ivana Josipovic, Matthias S. Leisegang, Christian Fork, Jens Preussner et autres

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Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5

Christian Fork, Lunda Gu, Juliane Hitzel, Ivana Josipovic et autres

OBJECTIVE: Altering endothelial biology through epigenetic modifiers is an attractive novel concept, which is, however, just in its beginnings. We therefore set out to identify chromatin modifiers important for endothelial gene expression and contributing to angiogenesis. APPROACH AND RESULTS: To identify chromatin …

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