Krishnamoorthy Sreenivasan

SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF

Poonam Kumari, Shahriar Tarighi, Eva Fuchshuber, Luhan Li et autres

Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylases, known as sirtuins. It acts as a potent oncogene in numerous malignancies, but the molecular mechanisms employed by SIRT7 to sustain lung cancer …

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Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice

Holger Lörchner, Juan M. Adrian-Segarra, Christian Waechter, Roxanne Wagner et autres

Oncostatin M (OSM) and leukemia inhibitory factor (LIF) signaling protects the heart after myocardial infarction (MI). In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective cognate ligands while OSM activates both the OSMR …

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CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

Krishnamoorthy Sreenivasan, Alejandra Rodríguez‐delaRosa, Johnny Kim, Diana Mesquita et autres

Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of satellite cells. We …

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Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles

Krishnamoorthy Sreenivasan, Alessandro Ianni, Carsten Künne, Boris Strilić et autres

Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not fully understood. Here, we show that a …

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Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

Jens Preussner, Jiasheng Zhong, Krishnamoorthy Sreenivasan, Stefan Günther et autres

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The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice

Juan M. Adrian-Segarra, Krishnamoorthy Sreenivasan, Praveen Gajawada, Holger Lörchner et autres

The pleiotropic interleukin-6 (IL-6)-type cytokine oncostatin M (OSM) signals in multiple cell types, affecting processes such as cell differentiation, hematopoiesis, and inflammation. In humans, OSM exerts its effects through activation of either of two different heterodimeric receptor complexes, formed by glycoprotein 130 …

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Systematic Identification of Genes Regulating Muscle Stem Cell Self-Renewal and Differentiation

Krishnamoorthy Sreenivasan, Thomas W Braun, Johnny Kim

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The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

Pablo Gómez‐del Arco, Eusebio Perdiguero, Paula Sofía Yunes-Leites, Rebeca Acín‐Pérez et autres

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Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate

Ramesh Kumar Krishnan, Hendrik Nolte, Tianliang Sun, Harmandeep Kaur et autres

The inhibitor of the nuclear factor-κB (IκB) kinase (IKK) complex is a key regulator of the canonical NF-κB signalling cascade and is crucial for fundamental cellular functions, including stress and immune responses. The majority of IKK complex functions are attributed to NF-κB …

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Synthesis of thiamine by moulds.

Chandrasekharan Ramakrishnan, Krishnamoorthy Sreenivasan