Laura Barlow

The Goldilocks Zone for 3‐T MRS Studies Using Semi‐LASER: Determining the Optimal Balance Between Repetition Time and Scan Time

Alex Ensworth, Laura Barlow, Piotr Kozłowski, Erin L. MacMillan et autres

ABSTRACT 1 H‐MR spectroscopy studies often use a short TR to reduce scan time. However, this causes significant T 1 ‐weighting (T 1 w), which can alter metabolite estimates due to acquisition factors rather than biochemistry. Our goal was to determine the …

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Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study

René Labounek, Monica T. Bondy, Amy Paulson, Sandrine Bédard et autres

Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e., height and weight) are mostly lacking in …

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The Goldilocks zone for 3T MRS studies using semi-LASER: Determining the optimal balance between repetition time and scan time using FSL-MRS

Alex Ensworth, Laura Barlow, Piotr Kozłowski, Erin L. MacMillan et autres

Motivation: A short TR is often used in clinical MRS brain studies, leading to T1-weighting of metabolites and inaccurate T1 correction. Goal(s): To determine the optimal balance between scan time and TR that minimizes T1-weighting effects when using semi-LASER MRS. Approach: SNR …

Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study

René Labounek, Monica T. Bondy, Amy Paulson, Sandrine Bédard et autres

Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e. height and weight) are mostly lacking in …

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Progressive steps towards a standardized MRI protocol for people with multiple sclerosis in British Columbia

David Li, Samuel Yim, Laura Barlow, Monty Martin et autres

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Making myelin water imaging “normal”: Robust acquisition for cervical cord with low peripheral nerve stimulation

Sharada Balaji, Adam Dvorak, Neale Wiley, Laura Barlow et autres

The standard myelin water imaging (MWI) sequence for cervical spinal cord, 3D gradient and spin echo (GRASE), was modified to allow scanning in “normal mode” (limiting imaging parameters that may cause physiologic stress) for patients who may not tolerate peripheral nerve stimulation …

semi-LASER MRS at 3T with TR=5s: All the Signal, Similar Scan Time, and Minimal T1 Weighting

Alex Ensworth, Laura Barlow, Piotr Kozłowski, Erin L. MacMillan et autres

The choice of repetition time (TR) in MR spectroscopy studies is widely debated. A shorter TR results in more clinically acceptable scan times, however due to T1 effects, the metabolite concentrations are reduced. We used semi-LASER MRS to compare the SNR and …

Nonaqueous magnetization following adiabatic and selective pulses in brain: T1 and cross‐relaxation dynamics

Luke A. Reynolds, Sarah Morris, Irene M. Vavasour, Laura Barlow et autres

Abstract Inversion pulses are commonly employed in MRI for ‐weighted contrast and relaxation measurements. In the brain, it is often assumed that adiabatic pulses saturate the nonaqueous magnetization. We investigated this assumption using solid‐state NMR to monitor the nonaqueous signal directly following …

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Predictive Value of Acute Neuroplastic Response to rTMS in Treatment Outcome in Depression: A Concurrent TMS-fMRI Trial

Ruiyang Ge, Afifa Humaira, Elizabeth Gregory, Golnoush Alamian et autres

OBJECTIVE: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. METHODS: Cross-sectional changes in functional connectivity induced by a single concurrent rTMS-fMRI session were …

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen‐Adad, Eva Alonso‐Ortiz, Mihael Abramovic, Carina Arneitz et autres

In the original version of this Data Descriptor, the Figure 4 legend was a duplicate of the Figure 3 legend. The Figure 4 legend has now been corrected to read as follows in both the PDF and HTML versions of the Data …

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen‐Adad, Eva Alonso‐Ortiz, Mihael Abramovic, Carina Arneitz et autres

In the original version of this Data Descriptor, the legend to Figure 16 incorrectly stated that the figure depicts the results of the multi-subject study for the MT protocol and that the mean MTR was computed. The legend has now been corrected …

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Generic acquisition protocol for quantitative MRI of the spinal cord

Julien Cohen‐Adad, Eva Alonso‐Ortiz, Mihael Abramovic, Carina Arneitz et autres

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