Erin L. MacMillan

Longitudinal magnetic resonance spectroscopy study of metabolite changes over 2 years in relapsing and primary progressive multiple sclerosis treated with ocrelizumab

Erin L. MacMillan, Bretta Russell‐Schulz, Glaynel Alejo, Christopher Harp et autres

Background: Magnetic resonance spectroscopy (MRS) offers non-invasive assessments of neuron–oligodendrocyte coupling and neuroinflammation to monitor treatment response in multiple sclerosis (MS). Objective: To track changes in N-acetylaspartate and myo-inositol in relapsing MS (RMS) and primary progressive MS (PPMS) patients treated with ocrelizumab …

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Design of Differential Single‐Block and Multi‐Block Presaturated Ultrashort Echo Time Pulse Sequences for Fast and Flexible Short‐ T 2 Imaging

Jason A. Reich, Shannon L. Taylor, Kevin D. Harkins, Rachelle Crescenzi et autres

ABSTRACT Purpose Ultrashort echo time (UTE) techniques are essential for the magnetic resonance imaging of short‐ T 2 signals. Current UTE techniques are time‐consuming and often require the acquisition of an inflexible volume. In this work, we implement new UTE sequences—differential single‐block …

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Design of a differential single-band presaturated ultrashort echo time (dSB-UTE) sequence for accelerated short-T2 imaging

Jason Reich, Kevin D. Harkins, Rachelle Crescenzi, Erin L. MacMillan et autres

Motivation: Short-T2 imaging requires ultrashort echo time (UTE) sequences with long scan times. The PINS-UTE sequence uses simultaneous multi-slice techniques to reduce UTE scan times, but its prepulse results in short-T2 signal loss and out-of-slice signal. Goal(s): To implement a novel differential …

Application of the power independent of number of slices presaturated ultrashort echo time (PINS-UTE) sequence to sodium MRI

Jason Reich, Erin L. MacMillan, Rebecca Feldman

Motivation: Sodium (23Na) MRI produces images with complimentary information about tissue viability; however time-consuming ultrashort echo time (UTE) sequences are required. Simultaneous multi-slice techniques reduce scan times, but were not compatible with UTE sequences until the PINS-UTE sequence was developed. Goal(s): To …

Improving Temporal Resolution in fMRS: Assessing Reduced Phase Cycling in semi-LASER MRS

Alex Ensworth, John Kramer, Erin L. MacMillan, Cornelia Laule

Motivation: Phase cycling is important for removal of ghosts but limits temporal resolution of functional MRS (fMRS). Goal(s): To investigate the effects of reducing phase cycle steps in semi-LASER fMRS to enhance temporal resolution while maintaining data integrity. Approach: Static 1H-MRS on …

Radio frequency coil failure assessment through characterization of coil noise

Krystyna Mylostna, Seger Nelson, Islam Osman, Mohamed Shehata et autres

Motivation: Clinical imaging which occurs between coil failure and quality assurance detection of coil failure can be costly and detrimental to patient care. Efficient, automated quality assurance has the potential to reduce rescans and improve imaging reliability. Goal(s): Explore noise characteristics in …

Myelin water and tensor‐valued diffusion imaging: (How) are they related?

Sharada Balaji, Adam Dvorak, Neale Wiley, Erin L. MacMillan et autres

Abstract Purpose Conventional MRI offers limited insight into specific characteristics of central nervous system tissue, whereas quantitative MRI measures can provide more detailed information about different aspects of microstructure. A multi‐metric approach involving multiple quantitative measures may improve our understanding of healthy …

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Glutamate levels in the cingulate cortex are associated with objective markers of pain sensitivity by way of pre-stimulus alpha band oscillations

Paulina S. Scheuren, Oscar Ortiz, Lukas D. Linde, Cassandra M. Choles et autres

• Glutamate signaling across the cingulate cortex is related to laser evoked potential amplitudes. • The effect of the ACC/PCC glutamate ratio on LEP amplitudes is mediated by pre-stimulus alpha band oscillations. • Brain metabolites and spontaneous brain fluctuations shape subsequent individual …

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The Goldilocks Zone for 3‐T MRS Studies Using Semi‐LASER: Determining the Optimal Balance Between Repetition Time and Scan Time

Alex Ensworth, Laura Barlow, Piotr Kozłowski, Erin L. MacMillan et autres

ABSTRACT 1 H‐MR spectroscopy studies often use a short TR to reduce scan time. However, this causes significant T 1 ‐weighting (T 1 w), which can alter metabolite estimates due to acquisition factors rather than biochemistry. Our goal was to determine the …

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Assessment of 1H-MRS spectra via multiset canonical correlation analysis and empirical mode decomposition

Alieh Ahdi, Alex Ensworth, B. Schulz, Erin L. MacMillan et autres

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Integrating Structural, Functional, and Biochemical Brain Imaging Data with MRShiny Brain - An Interactive Web Application

Jessica Archibald, Alexander Mark Weber, Paulina S. Scheuren, Oscar Ortiz et autres

Archibald et al., (2024). Integrating Structural, Functional, and Biochemical Brain Imaging Data with MRShiny Brain - An Interactive Web Application. NeuroLibre Reproducible Preprints, 29, https://doi.org/10.55458/neurolibre.00029

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Perivascular space semi-automated segmentation (PVSSAS) of 7T images from patients with and without epilepsy following traumatic brain injury

Jason Reich, Krystyna Mylostna, Kristen Dams-O'Connor, Katherine Dorman et autres

Motivation: Perivascular spaces (PVSs) are small fluid-filled spaces between blood vessels and pia mater. PVSs may appear differently in traumatic brain injury (TBI) patients with and without post-traumatic epilepsy (PTE) due to their role in waste removal. Goal(s): To investigate characteristics of …