Wenyuan Guo

DAE-Net: A Dual-View asymmetric extraction network with pathology-Aware Multi-level fusion for gastrointestinal tumour classification

Siyao Liu, Jiayi Xu, Jiaxi Mao, Yazhou Wang et autres

gb, cn (code pays fourni par la source)

Causal association between oral microbiota and hepatocellular carcinoma in East Asian populations: a Mendelian randomization study.

Hanxiang Zhong, Yuanyu Zhao, Hong Fu, Jiayong Dong et autres

OBJECTIVES: Emerging evidence highlights the crucial role of the oral microbiota in various malignancies, but its causal relationship with hepatocellular carcinoma (HCC) remains largely unexplored. This study aimed to investigate the causal association between oral microbiota composition and HCC risk in East …

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Comprehensive bioinformatic analysis reveals sorafenib response-related prognostic signature in hepatocellular carcinoma

Yuanyu Zhao, Junfeng Dong, Han-Xiang Zhong, Liang Peng et autres

Background: Sorafenib is the first-line treatment agent for advanced hepatocellular carcinoma (HCC), but it is effective in very few patients. Thus, this study was intended to identify gene signatures associated with sorafenib response in HCC and construct a prognostic risk model based …

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LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model

Zhiling Zhang, Songlin Li, Si Zhu, Chong Li et autres

BACKGROUND: Pathological α-synuclein (α-syn) can spread from the gut to the central nervous system (CNS), with CD4 + T cells playing a key role in this process. Lymphocyte activation gene 3 (LAG3) is involved in intestinal inflammation, regulates CD4 + T cell …

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ATP6V0A1 protects dopaminergic neurons via the autophagy–lysosomal pathway in Parkinson’s disease

Yuwan Lin, Zixin Tan, Wenfeng Ye, Weimin Li et autres

Parkinson’s disease is the second most common neurodegenerative disorder. ATPase H+ transporting V0 subunit A1 (ATP6V0A1) is a component of vacuolar H+-ATPase (V-ATPase), an ATP-dependent proton pump. Our previous research identified an association between the ATP6V0A1 rs601999 variant and Parkinson’s disease; however, …

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Upregulation of PD-1 on Peripheral T cells Subsets is Associated with Parkinson's Disease

Zhiling Zhang, Panghai Ye, Jin Li, Si Zhu et autres

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LncRNA Tug1 Regulates Post-Stroke Microglial Pyroptosis via PINK1/Parkin-Mediated Mitophagy

Meiling Yao, Xiaobei Wang, Hao Lin, Hui Shu et autres

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Corrigendum: Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease

Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li et autres

Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease by Qiu J, Peng G, Tang Y, Li S, Liu Z, Zheng J, Wang Y, Liu H, Wei L, Su Y, Lin Y, Dai W, …

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Optimal Preservation of PFFs in Glycerol Enhances Suitability for Modeling Parkinson's Disease

Hengxu Mao, Yaoyun Kuang, Weiqing Huang, Tingting Gan et autres

Injecting α-synuclein pre-formed fibrils (αSyn PFFs) into various tissues and organs involves converting monomeric αSyn into a fibrillar form, inducing extensive αSyn pathology that effectively models Parkinson's disease (PD). However, the distinct physicochemical properties of αSyn amyloid fibrils can potentially reduce their …

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Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease

Hengxu Mao, Yaoyun Kuang, Feng Du, Xiang Chen et autres

BACKGROUND: Seed amplification assays (SAA) enable the amplification of pathological misfolded proteins, including α-synuclein (αSyn), in both tissue homogenates and body fluids of Parkinson's disease (PD) patients. SAA involves repeated cycles of shaking or sonication coupled with incubation periods. However, this amplification …

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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease

Yaoyun Kuang, Hengxu Mao, Tingting Gan, Wenyuan Guo et autres

The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically accessible biospecimens. Despite its efficiency and specificity, optimal tissue-specific conditions for distinguishing Parkinson's disease (PD) from non-PD outside the brain remain underexplored. …

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Propensity score matching is recommended for retrospective comparative analysis of sarcopenia’s clinical prognostic impact on hepatocellular carcinoma resection patients in Eastern and Western cohorts

Jia-Xi Mao, Jing‐Jing Li, Yuanyu Zhao, Han-Xiang Zhong et autres

Mao, Jia-Xi MM; Li, Jing-Jing MM; Zhao, Yuan-Yu BMed; Zhong, Han-Xiang MM; Lu, Xin-Yi MM; Zhu, Li-Ye BMed; Fu, Hong MD; Ding, Guo-Shan MD; Guo, Wen-Yuan MD; Teng, Fei MD Author Information

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