Yuwan Lin

Anxiety in male psoriasis mouse model is mediated by the interaction between γδ T cell-derived IL-17A and microglia

Juexi Yang, Song Zhang, Cuiying Fu, Yan Dai et autres

cn, hk (code pays fourni par la source)

Transaldolase 1 impacts Parkinson’s disease pathogenesis via metabolic reprogramming and autophagy-lysosomal pathway

Zixin Tan, Huimin Hu, Hao Chen, Yuwan Lin et autres

Parkinson's disease (PD) progression involves dopaminergic neurodegeneration and pathological α-synuclein aggregation, processes linked to metabolic dysregulation and autophagy-lysosomal pathway (ALP) impairment. Transaldolase1 (TAL1) is a key enzyme of the pentose phosphate pathway. While elevated TAL1 protein levels have been observed in postmortem …

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MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity

Pallavi Asthana, Liguo Li, Lin Lü, Jiayan Wu et autres

Obesity has been linked to an increased risk of cognitive impairment and dementia in later life. Although aging and obesity are both associated with cognitive decline, it remains unclear how they interact to affect cognitive function across the lifespan and how brain …

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Identification of a novel mutation in RBM10 gene: A case report of TARP syndrome with deletion mutation

Xiaodan Chen, Wen Zhang, Yuwan Lin

Background RNA-binding motif protein 10 plays a crucial role in RNA splicing and is implicated in various human diseases, including Tracheoesophageal-Absent Radius-Polydactyly syndrome. Previously considered universally fatal in the early neonatal period, recent cases have demonstrated patients surviving beyond this stage. To …

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ATP6V0A1 protects dopaminergic neurons via the autophagy–lysosomal pathway in Parkinson’s disease

Yuwan Lin, Zixin Tan, Wenfeng Ye, Weimin Li et autres

Parkinson’s disease is the second most common neurodegenerative disorder. ATPase H+ transporting V0 subunit A1 (ATP6V0A1) is a component of vacuolar H+-ATPase (V-ATPase), an ATP-dependent proton pump. Our previous research identified an association between the ATP6V0A1 rs601999 variant and Parkinson’s disease; however, …

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Corrigendum: Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease

Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li et autres

Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease by Qiu J, Peng G, Tang Y, Li S, Liu Z, Zheng J, Wang Y, Liu H, Wei L, Su Y, Lin Y, Dai W, …

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Time and Space Dual‐Blockade Strategy for Highly Invasive Nature of Triple‐Negative Breast Cancer in Enhanced Sonodynamic Therapy Based on Fe‐MOF Nanoplatforms

Cheng Cao, Yi Lu, Xinni Pan, Yuwan Lin et autres

Abstract Triple‐negative breast cancer (TNBC), due to its high malignant degree and strong invasion ability, leads to poor prognosis and easy recurrence, so effectively curbing the invasion of TNBC is the key to obtaining the ideal therapeutic effect. Herein, a therapeutic strategy …

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Correlation of SV2C rs1423099 single nucleotide polymorphism with sporadic Parkinson's disease in Han population in Southern China

Zixin Tan, Yuwan Lin, Miaomiao Zhou, Wenyuan Guo et autres

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Integrated analysis of copy number variation-associated lncRNAs identifies candidates contributing to the etiologies of congenital kidney anomalies

Yibo Lu, Yiyang Zhou, Jing Guo, Ming Qi et autres

Abstract Congenital anomalies of the kidney and urinary tract (CAKUT) are disorders resulting from defects in the development of the kidneys and their outflow tract. Copy number variations (CNVs) have been identified as important genetic variations leading to CAKUT, whereas most CAKUT-associated …

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CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson’s disease

Xiang Chen, Yuwan Lin, Zhiling Zhang, Yuting Tang et autres

Mitochondrial dysfunction is a significant pathological alteration that occurs in Parkinson’s disease (PD), and the Thr61Ile (T61I) mutation in coiled-coil helix coiled-coil helix domain containing 2 (CHCHD2), a crucial mitochondrial protein, has been reported to cause Parkinson’s disease. F1F0-ATPase participates in the …

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Copy number variation-associated lncRNAs may contribute to the etiologies of congenital heart disease

Yibo Lu, Qing Fang, Ming Qi, Xiaoliang Li et autres

Copy number variations (CNVs) have long been recognized as pathogenic factors for congenital heart disease (CHD). Few CHD associated CNVs could be interpreted as dosage effect due to disruption of coding sequences. Emerging evidences have highlighted the regulatory roles of long noncoding …

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Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson’s disease

Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li et autres

Background: Parkinson's disease (PD) is a progressive neurodegenerative disease with characteristic pathological abnormalities, including the loss of dopaminergic (DA) neurons, a dopamine-depleted striatum, and microglial activation. Lipid accumulation exhibits a close relationship with these pathologies in PD. Methods: Here, 6-hydroxydopamine (6-OHDA) was …

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