Hui Shu

Isolation and quantification of L1CAM/ATP1A3/GAP43-positive extracellular vesicles on a EVArray biochip as potential biomarkers for Parkinson’s disease

Yuwan Lin, Chunchen Liu, Zongtang Xu, Hui Shu et autres

cn (code pays fourni par la source)

Exploring potential genetic correlation and causality between cathepsins and neurodegenerative diseases: Insight from Mendelian randomization analyses

Hui Shu, Rongmao He, Ziting Zhu, Wenlong Zhang et autres

Background Previous research has exhibited a potential association between cathepsins and neurodegenerative diseases (NDDs). Nevertheless, the causal relationships between cathepsins and different types of NDDs remain inadequately clear. Objective We aim to explore the genetically correlation and causality between 4 NDDs and …

cn (code pays fourni par la source)

RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson’s disease mice

Liuyan Ding, Yuchen Xiao, Zongtang Xu, Ziting Zhu et autres

BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons. The development of effective neuroprotective therapies is severely hampered by the blood-brain barrier (BBB), which restricts drug delivery to the central nervous system. This study …

cn (code pays fourni par la source)

RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson’s disease mouse model

Hui Shu, Xingting Huang, Zhongqiang Su, Fengchu Liang et autres

Parkinson's disease (PD) is characterized by progressive neurodegeneration closely linked to neuroinflammation and oxidative stress-induced damage and is characterized by the loss of dopaminergic (DAergic) neurons and the inflammatory response associated with glial cells. RRx-001 (RRx, 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone) is a small-molecule immunoregulator. Recent …

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LncRNA Tug1 Regulates Post-Stroke Microglial Pyroptosis via PINK1/Parkin-Mediated Mitophagy

Meiling Yao, Xiaobei Wang, Hao Lin, Hui Shu et autres

cn (code pays fourni par la source)