Liang Peng

Comprehensive bioinformatic analysis reveals sorafenib response-related prognostic signature in hepatocellular carcinoma

Yuanyu Zhao, Junfeng Dong, Han-Xiang Zhong, Liang Peng et autres

Background: Sorafenib is the first-line treatment agent for advanced hepatocellular carcinoma (HCC), but it is effective in very few patients. Thus, this study was intended to identify gene signatures associated with sorafenib response in HCC and construct a prognostic risk model based …

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Sequential Chemo-Immunotherapy as a Novel Bridging Strategy for Non-Complete Responders after Neoadjuvant Chemoradiotherapy in Esophageal Cancer: First Prospective Phase 2 Trial Challenging Immediate Surgery Paradigm

Qi Wang, Liang Peng, Cheng Wang, Wei He et autres

GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia

Lingzhi Lai, Hao Wu, Liang Peng, Zhen Zhang et autres

Purpose: Limb ischemia is a refractory disease characterized by insufficient angiogenesis and tissue necrosis. Currently, the primary clinical treatment method is surgical intervention; however, the prognosis for patients with severe limb ischemia remains unsatisfactory. Although some studies have evaluated the effects of …

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Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice

Shuang Chen, Chen‐Song Huang, Kang Li, Maosheng Cheng et autres

Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade immune elimination remains poorly characterized. Combining single-cell RNA-Seq (scRNA-Seq), dual-recombinase-based lineage tracing, and other approaches, we identified a WNT-activated subpopulation of malignant cells that act …

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Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

Kang Li, Caihua Zhang, Ruoxing Zhou, Maosheng Cheng et autres

Head and neck squamous cell carcinoma (HNSCC) is characterized by high recurrence or distant metastases rate and the prognosis is challenging. There is mounting evidence that tumor-infiltrating B cells (TIL-Bs) have a crucial, synergistic role in tumor control. However, little is known …

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SOX18 meditates the resistance of Bmi1‐expressing cells to cetuximab in HNSCC

Caihua Zhang, Zhi Chen, Nailin Gao, Gan Xiong et autres

OBJECTIVE: Head and neck squamous cell carcinoma (HNSCC) is the most common type of malignancy in the head and neck region worldwide. The therapeutic strategies for HNSCC remain unsatisfying and limited. Here, we found a population of resistant Bmi1-expressing cells in the …

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RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac 4 C modification

Xiaochen Wang, Kang Li, Maosheng Cheng, Hao Xu et autres

Abstract NAT10 is dysregulated and plays an essential role in various types of cancers. However, the exact machenism of how NAT10 regulates cancer progression remains debatable. In this report, we show that NAT10 affects tumorigeneis mainly based on its acetylation function on …

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High Expression of POGK Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma

Wenxiong Xu, Yanlin Huang, Yongyu Mei, Yeqiong Zhang et autres

Objective: Kruppel-associated box (KRAB) proteins reportedly play a dual role in neoplastic transformation. At present, little is known about the function of the proteins encoded by the human pogo transposable element derived with KRAB domain (POGK) gene. Herein, we evaluated the prognostic …

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The Role of miR-200c Decorated Liposomal Nanoparticles as a Carrier Target for Wnt/β-Catenin Signaling to Regulate Triple-Negative Breast Cancer Cell Line

Ping Fang, Liang Peng, Hangzheng Wang, Xin Zhang

Treatment of triple-negative breast cancer (TNBC) is not effective and prognosis is poor. This study explored the effect of miR-200c on triple-negative breast cancer cell line (TNBCC) and possible mechanism. L533 cell line was assigned into blank group, empty vector group (transfection …

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Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma

Xiaochen Wang, Kang Li, Yuehan Wan, Fangfang Chen et autres

Methyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation of METTL13 has been reported in a variety of tumors. However, little was known about its potential function in head and neck squamous cell carcinoma …

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Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway

Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang et autres

BACKGROUND: Radiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused on stem cell properties to obtain ideal therapeutic effects, and Sox9 has been reported to be involved in stem cell induction and …

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Corrigendum: Deficiency of Mettl3 in Bladder Cancer Stem Cells Inhibits Bladder Cancer Progression and Angiogenesis

Ganping Wang, Yarong Dai, Kang Li, Maosheng Cheng et autres

Incorrect Funding NumberThere is an error in the Funding statement. The correct number for Natural Science Foundation of Guangdong Province is no. 2018A030313610, and the correct number for National Natural Science Foundation of China is no. 81872409. The authors apologize for this …

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