Xiaobei Wang

Profiles and candidate educational targets of large language model dependence among Chinese nursing students: a cross-sectional study

Yiguo Deng, Luqing Liao, Xiaobei Wang, Siqi Wu et autres

Abstract Background Large language model (LLM) are increasingly applied in nursing education, yet the manifestations of LLM dependence remain unclear. This study aimed to explore the status, response characteristics, and candidate educational targets of LLM dependence among nursing students. Methods A cross-sectional …

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Musculoskeletal Adverse Events Following BCMA CAR T-Cell Therapy in Multiple Myeloma: Clinical Characteristics and Immune Correlates

Amber Feng, Jian Wu, Taewoong Choi, Xiaobei Wang et autres

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Process intensification of Dimethoxymethane–methanol azeotrope separation via ionic liquid-based extractive distillation: From computational screening to thermally integrated process optimization

Xueyu Lu, Xiaobei Wang, Duan Niu, Zhaoyang Liu et autres

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Beta-Arrestin 1 Deficiency Enhances Host Anti-Myeloma Immunity Through T Cell Activation and Checkpoint Modulation

Jian Wu, Xiaobei Wang, Shaima Jabbar, Niyant Ganesh et autres

Beta-arrestin 1 (ARRB1) is a multifunctional adaptor protein that regulates diverse signaling pathways beyond its canonical role in G-protein-coupled receptor desensitization. While ARRB1 has been implicated in cancer progression, its role in modulating host immunity against multiple myeloma (MM) remains unexplored. Here, …

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Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar et autres

Abstract Human thioredoxin‐1 (TRX) is a target‐selective disulfide reductase with antioxidant, anti‐inflammatory, and regulatory functions that mitigates cellular stresses in various organ systems, providing a compelling rationale for therapeutic use as a broad‐spectrum cell protectant. However, clinical application of recombinant TRX (rhTRX) …

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Progress of plant biomass nanomaterials in the adsorption and removal of environmental pollutants

Lu Wang, Zigong Shao, Hongmei Du, Wei Sun et autres

Environmental pollution caused by heavy metals, dyes, and emerging contaminants is a critical ecological and health risk. Recently, plant biomass-derived nanomaterials have emerged as promising green adsorbents for removing such pollutants, because of their abundance, renewability, and eco-friendly properties. This review systematically …

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Integrative single-cell RNA-seq and ATAC-seq identifies transcriptional and epigenetic blueprint guiding osteoclastogenic trajectory

Amitabh Das, Keita Saeki, Stefania Dell’Orso, Xiaobei Wang et autres

Osteoclasts (OCs) are multinucleated bone resorbing cells essential for skeletal development and remodeling. In adulthood, OCs originate from the serial fusion of monocytes, yet the transcriptional and epigenetic mechanisms shaping their osteoclastogenic potential at a single-cell resolution remain poorly understood. Here, we …

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Predicting Stroke-Associated Pneumonia in Acute Ischemic Stroke: A Machine Learning Model Development and Validation Study with CBC-Derived Inflammatory Indices

Mengqi Xie, Zhiying Liu, Dai Fangfang, Zhen Cao et autres

Purpose: Stroke-associated pneumonia (SAP), a critical complication of ischemic stroke, significantly worsens outcomes. Our aim was to identify SAP risk factors and develop a machine learning (ML) model for early risk stratification. Methods: This retrospective study analyzed 574 ischemic stroke patients, divided …

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Biomass fuel induces neuroinflammation and neurodegeneration via the astrocyte-microglia IL-17A/IL-17RA pathway

Fengchu Liang, Zongtang Xu, Liuyan Ding, Ziting Zhu et autres

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Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases

Huan Xia, Zihao Wang, Xiaobei Wang, Meirong Gao et autres

OBJECTIVE: This study aims to investigate the causal relationship between Mitochondrial DNA (mtDNA) copy number and several common neurodegenerative diseases (NDs). METHODS: We conducted a bidirectional two-sample Mendelian randomization (MR) analysis using data from genome-wide association studies (GWAS) as instrumental variables (IVs). …

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β-Arrestin 2 as a Prognostic Indicator and Immunomodulatory Factor in Multiple Myeloma

Parker Mathews, Xiaobei Wang, Jian Wu, Shaima Jabbar et autres

β-arrestin 2 (ARRB2) is involved in the desensitization and trafficking of G protein-coupled receptors (GPCRs) and plays a critical role in cell proliferation, apoptosis, chemotaxis, and immune response modulation. The role of ARRB2 in the pathogenesis of multiple myeloma (MM) has not …

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Machine Learning-Assisted Catalysts for Advanced Oxidation Processes: Progress, Challenges, and Prospects

Xiaobei Wang, Dongdong Xu, Hongyan Liu, Hanwen Zhang et autres

Advanced oxidation processes (AOPs) are recognized as one of the most effective methods in the field of wastewater treatment, and the selection of catalysts in the oxidation process is very important. In the face of the traditional test trial-and-error method, the method …

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