Paul S. Fishman

Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor

Michael G. Kaplitt, Vibhor Krishna, Howard M. Eisenberg, W. Jeffrey Elias et autres

Importance: Unilateral magnetic resonance-guided focused ultrasound ablation of ventralis intermedius nucleus of the thalamus for essential tremor reduces tremor on 1 side, but untreated contralateral or midline symptoms remain limiting for some patients. Historically, bilateral lesioning produced unacceptable risks and was supplanted …

us (code pays fourni par la source)

Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naïve patients with Parkinson’s disease

Li Jiang, Jiachen Zhuo, Andrew J. Furman, Paul S. Fishman et autres

Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting both motor and cognitive function. Previous neuroimaging studies have reported altered functional connectivity (FC) in distributed functional networks. However, most neuroimaging studies focused on patients at an advanced stage and with antiparkinsonian …

us (code pays fourni par la source)

Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

Vibhor Krishna, Paul S. Fishman, Howard M. Eisenberg, Michael G. Kaplitt et autres

BACKGROUND: Unilateral focused ultrasound ablation of the internal segment of globus pallidus has reduced motor symptoms of Parkinson's disease in open-label studies. METHODS: We randomly assigned, in a 3:1 ratio, patients with Parkinson's disease and dyskinesias or motor fluctuations and motor impairment …

us, kr, tw, es, it, ca, il (code pays fourni par la source)

Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases

Paul S. Fishman, Jonathan M. Fischell

The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease modifying therapies …

us (code pays fourni par la source)

A Multifaceted Approach to Optimizing AAV Delivery to the Brain for the Treatment of Neurodegenerative Diseases

Jonathan M. Fischell, Paul S. Fishman

Despite major advancements in gene therapy technologies, there are no approved gene therapies for diseases which predominantly effect the brain. Adeno-associated virus (AAV) vectors have emerged as the most effective delivery vector for gene therapy owing to their simplicity, wide spread transduction …

us (code pays fourni par la source)

MR-guided focused ultrasound pallidotomy for Parkinson’s disease: safety and feasibility

Howard M. Eisenberg, Vibhor Krishna, W. Jeffrey Elias, Garth Rees Cosgrove et autres

OBJECTIVE: Stereotactic radiofrequency pallidotomy has demonstrated improvement in motor fluctuations in patients with Parkinson's disease (PD), particularly levodopa (L-dopa)-induced dyskinesias. The authors aimed to determine whether or not unilateral pallidotomy with MR-guided focused ultrasound (MRgFUS) could safely improve Unified Dyskinesia Rating Scale …

us (code pays fourni par la source)

Reply to: Comment on “The Role of High‐Intensity Focused Ultrasound as a Symptomatic Treatment for Parkinson's Disease”

Shayan Moosa, Raúl Martínez‐Fernández, W. Jeffrey Elias, Marta del Álamo et autres

us, es (code pays fourni par la source)

Targeting of the dentato-rubro-thalamic tract for MR-guided focused ultrasound treatment of essential tremor

Timothy Ryan Miller, Jiachen Zhuo, Howard M. Eisenberg, Paul S. Fishman et autres

BACKGROUND: Magnetic resonance-guided focused ultrasound ablation of the thalamic ventral intermediate nucleus is a safe and effective treatment for medically refractory essential tremor. However, indirect targeting of the ventral intermediate nucleus using stereotactic coordinates from normal neuroanatomy can be inefficient. We therefore …

us (code pays fourni par la source)

The role of high‐intensity focused ultrasound as a symptomatic treatment for Parkinson's disease

Shayan Moosa, Raúl Martínez‐Fernández, W. Jeffrey Elias, Marta del Álamo et autres

MR-guided focused ultrasound is a novel, minimally invasive surgical procedure for symptomatic treatment of PD. With this technology, the ventral intermediate nucleus, STN, and internal globus pallidus have been targeted for therapeutic cerebral ablation, while also minimizing the risk of hemorrhage and …

us, es (code pays fourni par la source)

Enhancement of FUS Mediated Delivery of Stem Cells to Brain

Paul S. Fishman

We propose that magnetic targeting of super-paramagnetic iron oxide nanoparticles (SPION) labeled cells will enhance the delivery of stem cells to brain after focused ultrasound (FUS) mediated opening of the blood-brain barrier (BBB). FUS mediated opening of the BBB allowing stem cells …

A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions

Tapas Kumar Makar, Vamshi K.C. Nimmagadda, Poornachander Reddy Guda, Brian Hampton et autres

Adult bone marrow contains stem cells that replenish the myeloid and lymphoid lineages. A subset of human and mouse CD34 + bone marrow stem cells can be propagated in culture to autonomously express embryonic stem cell genes and embryonic germ layer lineage …

us, fr (code pays fourni par la source)

Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor

Paul S. Fishman, W. Jeffrey Elias, Pejman Ghanouni, Ryder P. Gwinn et autres

BACKGROUND: Magnetic resonance imaging-guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. OBJECTIVE: To determine the …

us, ca, kr, jp (code pays fourni par la source)