Accès ouvert
2025
article
OpenAlex
Pejman Ghanouni, Vibhor Krishna, Michael G. Kaplitt, W. Jeffrey Elias et autres
Essential tremor (ET) is a common neurologic disorder, with 30–50% of patients experiencing medication-refractory symptoms. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an approved, effective treatment for medication-refractory ET. In this open-label, continued access study, subjects were enrolled prospectively after the pivotal …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Pejman Ghanouni, Vibhor Krishna, Howard M. Eisenberg, W. Jeffrey Elias et autres
Background: Essential tremor (ET) is a common neurologic disorder, with 30-50% of patients experiencing medication-refractory symptoms. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an approved, effective treatment for medication-refractory ET. In this open-label, continued access study, subjects were enrolled prospectively after the …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Samira Pardakhtim, Landon Basner, Aiyush Bansal, Katie Krause et autres
Background and objectives Deep brain stimulation (DBS) has proven to be safe and effective in the treatment of certain movement disorders. Although the risk profile is low, surgical site infection (SSI) remains a common complication associated with DBS implantation. Currently, no standardized …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Brian Lee, Rachel Dalley, Jeremy A. Miller, Thomas Chartrand et autres
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain …
us, hu, dk
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A. Goriounova et autres
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 …
us, nl, hu
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Nelson Johansen, Saroja Somasundaram, Kyle J. Travaglini, Anna Marie Yanny et autres
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumor surgeries. Nearly all nuclei map to one of 125 …
us
(code pays fourni par la source)
2023
preprint
OpenAlex
Eline J. Mertens, Yoni Leibner, Jean L. Pie, Anna A. Galakhova et autres
ABSTRACT Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though human hippocampus underwent strong evolutionary reorganization and shows lower theta rhythm frequencies. To test whether …
nl, il, Afrique du Sud, us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Nelson Johansen, Saroja Somasundaram, Kyle J. Travaglini, Anna Marie Yanny et autres
Single cell gene expression studies have found that cell types are well-matched between species and related brain regions; however, matched cell types can show substantial differences in gene expression, abundance, or spatial location. Some cell types also change in neurological and psychiatric …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Monet et autres
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where there are major technical challenges in reliably …
us, it
(code pays fourni par la source)
Accès ouvert
2023
peer-review
OpenAlex
Mean-Hwan Kim, Cristina Radaelli, Elliot R. Thomsen, Deja Monet et autres
Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on their subclass interneuron identity.
us, it
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Vibhor Krishna, Paul S. Fishman, Howard M. Eisenberg, Michael G. Kaplitt et autres
BACKGROUND: Unilateral focused ultrasound ablation of the internal segment of globus pallidus has reduced motor symptoms of Parkinson's disease in open-label studies. METHODS: We randomly assigned, in a 3:1 ratio, patients with Parkinson's disease and dyskinesias or motor fluctuations and motor impairment …
us, kr, tw, es, it, ca, il
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Richard Rauck, Eric Loudermilk, Simon Thomson, J. Paz et autres
Aim: The availability of long-term (>2 years) safety outcomes of spinal cord stimulation (SCS) remains limited. We evaluated safety in a global SCS registry for chronic pain. Methods: Participants were prospectively enrolled globally at 79 implanting centers and followed out to 3 …
us, es, de, ca, ch, gb, il, au, it, jp, dk, se, be, nl
(code pays fourni par la source)