W. Jeffrey Elias

Unilateral magnetic resonance-guided focused ultrasound for medication-refractory essential tremor: 5-year continued access study

Pejman Ghanouni, Vibhor Krishna, Michael G. Kaplitt, W. Jeffrey Elias et autres

Essential tremor (ET) is a common neurologic disorder, with 30–50% of patients experiencing medication-refractory symptoms. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an approved, effective treatment for medication-refractory ET. In this open-label, continued access study, subjects were enrolled prospectively after the pivotal …

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Unilateral magnetic resonance-guided focused ultrasound for medication-refractory essential tremor: 5-year continued access study

Pejman Ghanouni, Vibhor Krishna, Howard M. Eisenberg, W. Jeffrey Elias et autres

Background: Essential tremor (ET) is a common neurologic disorder, with 30-50% of patients experiencing medication-refractory symptoms. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an approved, effective treatment for medication-refractory ET. In this open-label, continued access study, subjects were enrolled prospectively after the …

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An Improved 3D Stack-of-Spirals Sequence for Simultaneous Brain and Skull Thermometry in Clinical Transcranial MRgFUS Surgery

Sheng Chen, Steven G. Allen, John P. Mugler, W. Jeffrey Elias et autres

Motivation: Monitoring off-target heating of the skull and soft tissue during transcranial MRgFUS surgery is necessary. However, both T1- and PRF-based thermometry with the previously proposed sequence may be biased in clinical settings. Goal(s): To improve the accuracy of both T1 mapping …

Pain Catastrophising Amplifies Parietal Responses to Painful Laser Stimulation in Healthy Controls

Dan Wang, Xiaohan Zhang, Shuqi Ye, Patrick Realyvasquez et autres

BACKGROUND: Pain catastrophising is a maladaptive cognitive-emotional trait linked to greater pain severity and poorer outcomes, yet its neurophysiological correlates remain unclear. OBJECTIVES: We tested whether pain catastrophising amplifies cortical responses to nociceptive input, independent of subjective pain intensity. METHODS: Fifty-two healthy …

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Stereotactic Focused Ultrasound Mesencephalotomy for the Treatment of Head and Neck Cancer Pain

W. Jeffrey Elias, ChangChia James Liu, Divine C. Nwafor, Patrick H. Finan et autres

INTRODUCTION: Historically, stereotactic mesencephalotomy was developed as a "supraspinal" cordotomy for cancer and neuropathic pain. Early experiences relieved pain, but the procedure was never widely adopted because of the associated morbidity with midbrain lesioning. Contemporary image-guided lesioning could make this a feasible …

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Probabilistic Refinement of Focused Ultrasound Thalamotomy Targeting for Parkinson's Disease Tremor

Cletus Cheyuo, Jürgen Germann, Kazuaki Yamamoto, Zion Zibly et autres

Abstract Background There remains high variability in clinical outcomes when the same magnetic resonance image‐guided focused ultrasound (MRgFUS) thalamotomy target is used for both essential tremor (ET) and tremor‐dominant Parkinson's disease (TDPD). Objective Our goal is to refine the MRgFUS thalamotomy target …

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Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor

Michael G. Kaplitt, Vibhor Krishna, Howard M. Eisenberg, W. Jeffrey Elias et autres

Importance: Unilateral magnetic resonance-guided focused ultrasound ablation of ventralis intermedius nucleus of the thalamus for essential tremor reduces tremor on 1 side, but untreated contralateral or midline symptoms remain limiting for some patients. Historically, bilateral lesioning produced unacceptable risks and was supplanted …

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Essential Tremor

W. Jeffrey Elias, Binit Shah

This JAMA Insights discusses the diagnostic evaluation and treatment, including pharmacological, nonpharmacological, and surgical options, of essential tremor.

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Bilateral focused ultrasound medial thalamotomies for trigeminal neuropathic pain: a randomized controlled study

Mariam Ishaque, Shayan Moosa, Lori A. Urban, Bijoy K. Kundu et autres

OBJECTIVE: Medial thalamotomy has been shown to benefit patients with neuropathic pain, but widespread adoption of this procedure has been limited by reporting of clinical outcomes in studies without a control group. This study aimed to minimize confounders associated with medial thalamotomy …

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Role of High‐Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions

Georgios Α. Maragkos, Georgios Mantziaris, Shayan Moosa, W. Jeffrey Elias

MRI-guided focused ultrasound (MRgFUS) is increasingly used in lesioning for functional neurosurgery and neuro-oncology. Technological advances in transducer design and MR thermometry has allowed for the noninvasive lesioning of deep-seated structures under real-time monitoring. MRgFUS has received FDA approval for the treatment …

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A New Era for Lesioning in Parkinson Disease

Anant R. Tewari, Dayton P. Grogan, Georgios Α. Maragkos, W. Jeffrey Elias et autres

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Painful Cutaneous Laser Stimulation for Temporal Summation of Pain Assessment

Dan Wang, Shayan Moosa, Mariam Ishaque, Patrick H. Finan et autres

Variability in pain sensitivity arises not only from the differences in peripheral sensory receptors but also from the differences in central nervous system (CNS) pain inhibition and facilitation mechanisms. Temporal summation of pain (TSP) is an experimental protocol commonly used in human …

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