Toru Maruyama

CD169-positive macrophages in lymph nodes and the tumor microenvironment: harnessing their biology for clinical diagnosis and anticancer therapeutic strategies

Ryo Fukuda, Yukio Fujiwara, Toru Maruyama, Yoshihiro Komohara

CD169 + macrophages are strategically positioned in secondary lymphoid organs and diverse peripheral tissues, where they orchestrate tissue-specific immune homeostasis by regulating local cellular and humoral responses. In the context of cancer, CD169 + macrophages within tumor-draining lymph nodes (tdLNs) and the …

jp (code pays fourni par la source)

Unique response of polysulfide in serum albumin to oxidative stress

Mayumi Ikeda, Maki Wakuta Sakai, Keitaro Umezawa, Hidehiko Nakagawa et autres

H). The physiological activities of intracellular supersulfides have been widely studied, but little is known about the role of supersulfides in extracellular biological fluids. We therefore analyzed the pathological changes and oxidative stress responses of the reduced and oxidized forms of polysulfides …

jp, us (code pays fourni par la source)

Indoxyl Sulfate Contributes to Selenium Deficiency and Renal Ferroptosis by Decreasing the Expression of Selenium Transport Protein Selenoprotein P

Takehiro Nakano, Yutaka Kitazato, Kai Tokumaru, Yuhi Shintani et autres

Key Points Indoxyl sulfate (IS) is involved in the liver-kidney axis by inducing renal ferroptosis by selenium deficiency due to suppression of selenoprotein P (SEPP1) expression in the liver. IS concentrations were negatively associated with selenium concentrations and SEPP1 concentrations in serum …

jp (code pays fourni par la source)

Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages

Ryo Fukuda, Yukio Fujiwara, Hitoshi Maeda, Cheng Wei Pan et autres

Abstract Background CD169 + macrophages in lymph nodes (LNs) activate cytotoxic T lymphocytes (CTLs), which play a crucial role in anticancer immunity, through antigen presentation and co-stimulation by CD169. Interferon alpha (IFNα) is capable of inducing the CD169 + phenotype of macrophages; …

jp (code pays fourni par la source)

Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages

Hiroaki Matsuzaki, Keitaro Kai, Yoshihiro Komohara, Hiromu Yano et autres

Glioblastoma (GBM) involves disruptions in the blood-brain barrier (BBB) and alterations in the immune microenvironment, including the activation of glioma-associated macrophages (GAMs). Vascular endothelial growth factor inhibitors, commonly used in recurrent GBM treatment, can influence these processes. This study investigates the relationship …

jp (code pays fourni par la source)

Immunohistochemical Analysis of a1-Acid Glycoprotein and Tumor Associated Macrophages in Clear Cell Renal Cell Carcinoma

Ayano Ezaki, Hiromu Yano, Cheng Pan, Yukio Fujiwara et autres

BACKGROUND/AIM: α1-Acid glycoprotein (AGP), also known as orosomucoid, is an acute-phase protein that has been found increased in plasma of cancer patients. This study investigates the role of AGP expression in clear cell renal cell carcinoma (ccRCC) and its association with clinical …

jp (code pays fourni par la source)

Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages

Ryo Fukuda, Yukio Fujiwara, Hitoshi Maeda, Cheng Wei Pan et autres

jp (code pays fourni par la source)

Omega 3 Fatty Acids Attenuate the Acute Kidney Injury to CKD Transition and Renal Fibrosis

Kai Tokumaru, Tadashi Imafuku, Takao Satoh, Tomoaki Inazumi et autres

Key Points Omega-3 polyunsaturated fatty acids prevent AKI to CKD transition and renal fibrosis. Eicosapentaenoic acid metabolites 18-hydroxyeicosapentaenoic acid, 17,18-epoxyeicosatetraenoic acid, and 17,18-dihydroxyeicosatetraenoic acid have antifibrotic effects. Background AKI is an established risk factor for developing CKD. Recently, the renoprotective effect of …

jp (code pays fourni par la source)

Contribution of Phe112, Ser114, and Tyr115 to Drug-Binding Selectivity in the A Variant of α1-Acid Glycoprotein

Yuka Nakamura, Hiroshi Watanabe, Teruya Nakamura, Mami Chirifu et autres

-acid glycoprotein (AGP) primarily affects the pharmacokinetics of basic drugs. There are two AGP variants in humans, A and F1*S, exhibiting distinct drug-binding selectivity. Elucidation of the drug-binding selectivity of human AGP variants is essential for drug development and personalized drug therapy. …

jp (code pays fourni par la source)

Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation

Kazuaki Taguchi, Shigeru Ogaki, Hitoshi Maeda, Yu Ishima et autres

Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative agents for skeletal muscle ischemia injury are unavailable in clinics to date. …

jp (code pays fourni par la source)

Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application

Mayumi Ikeda, Tatsuya Fukuta, Yasunori Iwao, Masaki Otagiri et autres

Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in serum. Various methods for measuring supersulfides …

jp (code pays fourni par la source)

Omega 3 Fatty Acids Attenuated AKI to CKD Transition and Renal Fibrosis: Identification of Anti-Fibrotic Metabolites

Kai Tokumaru, Hiroshi Watanabe, Toru Maruyama

Background: Renal fibrosis, recognized as a histological hallmark of CKD, has become an object of interest as a prospective therapeutic target. Recent meta-analyses showed that the patients with AKI are at high risk of developing CKD, and the concept of AKI to …

jp (code pays fourni par la source)