Cheng Pan

Naringin promotes cancer immunity by inducing cross-presentation by antigen-presenting cells

Cheng Pan, Yukio Fujiwara, Daiki Yoshii, Jiahao Pan et autres

Successful immune checkpoint inhibitor (ICI) treatment of cancer requires adequate infiltration of cytotoxic CD8+T lymphocytes (CTLs) in tumors. Previous studies have identified the compound naringin, which increases CTL infiltration and rescues ICI efficacy in CTL-lacking tumors, and cancer CTL priming has been …

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Gut microbial remodeling as an ecological strategy for host metabolic management under environmental stress on the Xizang Plateau

Cheng Pan, Yangzong Zhaxi, Junru Pan, Cisang Zhuoma et autres

The adaptive responses of gut bacteria and host metabolism in Xizang sheep to the decline in forage quality and the extremehigh-altitude environment remain largely unclear. This study utilized Xizang sheep as a model, and employed 16S rRNA sequencing, metabolomics, and RT-qPCR to …

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Bile‐Derived Exosomal miR ‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida et autres

Bile-based liquid biopsy presents a promising approach for identifying novel biomarkers for biliary tract cancer (BTC) given its proximity to tumor sites. The aim of this study was to identify bile-derived exosomal microRNAs (miRNAs) with diagnostic potential for BTC. The candidate miRNAs …

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Moderate altitude exposure induced gut microbiota enterotype shifts impacting host serum metabolome and phenome

Yonghui Ma, Dingchen Wang, Xinyi Yu, Yanqun Fan et autres

BACKGROUND: Consistent patterns of gut microbiota variations, particularly in relative abundance, have been identified in the adult human gut. Enterotype, another general measure of the gut microbiota, is a valuable approach for categorizing the human gut microbiota into distinct clusters. The impact …

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Transaldolase PagTAL1 modulates ROS homeostasis to improve heat stress tolerance in Populus

Xinyuan Wu, Yufen Bu, Cheng Pan, Na Sun et autres

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Preconditioning With TGF‐β Inhibitors Enhances Therapeutic Efficacy of Endothelial Progenitor Cells for Wound Healing in Diabetic Mice

Dongsheng Su, Fuyi Cheng, Qingyuan Jiang, Yong Zhang et autres

Diabetic wound (DW) represent a common complication of diabetes. Despite advances in regenerative repair utilizing endothelial progenitor cells (EPCs), challenges such as low survival and impaired angiogenic function of EPCs remain. Herein, we explored an effective method to induce injury-induced protection for …

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The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma

Hiroyuki Yamada, Hiromu Yano, Eri Matsubara, Shukang Zhao et autres

Abstract Thyroid transcription factor-1 (TTF-1) is a lineage-specific marker for lung adenocarcinoma (LUAD), whereas the relatively minor subset of TTF-1-negative LUADs shows a poor prognosis and a limited response to therapy. However, its relationship with the tumor immune microenvironment remains poorly defined. …

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The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma

Hiromu Yano, Eri Matsubara, Shukang Zhao, Yusuke Shinchi et autres

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U-Net-Driven Method for Identifying Vehicle Moving Forces from Bridge Displacement Data

Zhufeng Shao, Zhiqiang Shang, Fangyu Wu, Cheng Pan et autres

The structural safety of bridges depends not only on their inherent performance but also on the external loads they endure. Traffic loads serve as the primary source of live loads during bridge operation, making accurate identification of vehicle-bridge interaction forces critical for …

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Immunohistochemical Analysis of a1-Acid Glycoprotein and Tumor Associated Macrophages in Clear Cell Renal Cell Carcinoma

Ayano Ezaki, Hiromu Yano, Cheng Pan, Yukio Fujiwara et autres

BACKGROUND/AIM: α1-Acid glycoprotein (AGP), also known as orosomucoid, is an acute-phase protein that has been found increased in plasma of cancer patients. This study investigates the role of AGP expression in clear cell renal cell carcinoma (ccRCC) and its association with clinical …

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Progress of research on PD-L1 inhibitor adebrelimab usage in malignant tumors

Cheng Pan, Jichen He, Pingping Cheng, Kaixia Chen et autres

Adebrelimab is a humanized monoclonal antibody against programmed death-ligand 1 (PD-L1) and is also a novel immune checkpoint inhibitor, which has been used in the first-line treatment of extensive stage small cell lung cancer (SCLC) with its unique mechanism of action and …

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Correction: Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway

Rikito Tatsuno, Jiro Ichikawa, Yoshihiro Komohara, Cheng Pan et autres

The graph presented in the original Supplementary figure 4 was incorrect and has been replaced by a correct version. The original article has been corrected.

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