Keitaro Kai

Systematic Review Protocol on Women in Neurosurgery

Noeru Kawase, Shunsuke Nakae, Masanobu Kumon, Keitaro Kai

Sensitivity analysisNo sensitivity analysis is planned because this review will not perform quantitative meta-analysis or statistical pooling of effect estimates.The analysis will consist primarily of descriptive and qualitative synthesis of the included literature.

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Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages

Hiroaki Matsuzaki, Keitaro Kai, Yoshihiro Komohara, Hiromu Yano et autres

Glioblastoma (GBM) involves disruptions in the blood-brain barrier (BBB) and alterations in the immune microenvironment, including the activation of glioma-associated macrophages (GAMs). Vascular endothelial growth factor inhibitors, commonly used in recurrent GBM treatment, can influence these processes. This study investigates the relationship …

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PATH-40. CLINICAL CHARACTERIZATION OF H3K27M-MUTANT GLIOMAS

Tatsuya Takezaki, Jun‐ichiro Kuroda, Naoki Shinojima, Keitaro Kai et autres

Abstract Diffuse midline gliomas, H3K27M-altered(DMGs) are a recently defined entity of gliomas, occur in midline, infiltrate diffusely and have poor prognosis. We reviewed our cases of DMGs to describe clinical, pathological, molecular characteristics, retrospectively. We detected 39 H3K27M-mutant cases of our 959 …

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The roles of glioma-associated macrophages/microglia and potential targets for anti-glioma therapy

Hiroaki Matsuzaki, Cheng Wei Pan, Yoshihiro Komohara, Rin Yamada et autres

Glioblastoma (GBM) is the central nervous system tumor with the most aggressive behavior, and no definitive therapy has yet been found. The tumor microenvironment of GBM is immunosuppressive and is considered a 'cold tumor' with low lymphocytic infiltration, but is characterized by …

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Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage

Hiroki Uchikawa, Koki Kameno, Keitaro Kai, Sosho Kajiwara et autres

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A Consideration of Optimal Head Position in Transsylvian Selective Amygdalohippocampectomy

Tadashi Hamasaki, Hiroki Uchikawa, Tatsuya Kawano, Keitaro Kai et autres

Transsylvian selective amygdalohippocampectomy (TSA) is one of the predominant surgical options for drug-resistant mesial temporal lobe epilepsy. The purpose of this article is to highlight the unique features of TSA and determine the setting to perform safe and secure TSA with special …

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Macrophage colony‐stimulating factor potentially induces recruitment and maturation of macrophages in recurrent pituitary neuroendocrine tumors

Hiroaki Matsuzaki, Yoshihiro Komohara, Hiromu Yano, Yukio Fujiwara et autres

Although pituitary neuroendocrine tumors (PitNETs) are usually benign, some are highly invasive and recurrent. Recurrent PitNETs are often treatment-resistant and there is currently no effective evidence-based treatment. Tumor-associated macrophages (TAMs) promote tumor growth in many cancers, but the effect of TAMs on …

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Gliosarcoma with Systemic Metastasis Showing Favorable Response to Ifosfamide, Carboplatin, and Etoposide Chemotherapy: An Autopsy Case Report

Yuki NAKAGAKI, Keitaro Kai, Yoshihiro Komohara, Tatsuya Takezaki et autres

Gliosarcoma is a rare malignant neoplasm. It accounts for approximately 2% of all glioblastomas. To date, there is no established treatment method for gliosarcoma, and a variety of therapies, such as surgical resection, radiotherapy, and chemotherapy, are typically employed. Here, we describe …

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Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy

Hiromu Yano, Yukio Fujiwara, Hasita Horlad, Pan Chang et autres

Cholesterol is an essential plasma membrane lipid for the maintenance of cellular homeostasis and cancer cell proliferation. Free cholesterol is harmful to cells; therefore, excessive free cholesterol must be quickly esterified by acetyl-coenzyme A:cholesterol acetyltransferase (ACAT) and exported by scavenger receptor class …

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マクロファージ由来のIL-1βはSTAT3/NF-κB経路を介して膠芽腫の増殖を誘導する

Keitaro Kai

IM-8 Significance of IL-1 pathways in Glioblastoma

Keitaro Kai, Yoshihiro Komohara, Takahiro Yamamoto, Ken Uekawa et autres

Abstract Purpose: Previous studies have revealed that macrophages affect the prognosis of glioblastoma. However, there are still many unknown parts about the mechanism. In this study, we conducted an experiment with the aim of elucidating the mechanism by which tumor associated macrophages …

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Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway

Keitaro Kai, Yoshihiro Komohara, Shigeyuki Esumi, Yukio Fujiwara et autres

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