M. Saïd Ghandour

Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination

Giada Delfino, Karelle Bénardais, Julien Graff, Brigitte Samama et autres

The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in some neurological and psychiatric …

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A Challenging Case of Corpus Callosum Anaplastic Astrocytoma

Ahmed K A Ahmed, Ahamed M. Elkhair, Omeralfaroug Adam, M. Saïd Ghandour et autres

Anaplastic astrocytoma is a rare, malignant brain tumor that arises from astrocytes, with a poor prognosis. Herein, we report a challenging diagnostic case of a 76 years old female with an Anaplastic astrocytoma metastasized to the corpus callosum.

Correction: Novel variants in COL4A4 and COL4A5 are rare causes of FSGS in two unrelated families

Stephanie L. Hines, Anjali Agarwal, M. Saïd Ghandour, Nabeel Aslam et autres

The originally published version of this Article contained an error in the name of the author Nabeel Aslam, which was incorrectly given as Aslam Nabeel. This has now been corrected in both the PDF and HTML versions of the Article.

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Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice

Flurin Cathomas, Damiano Azzinnari, Giorgio Bergamini, Hannes Sigrist et autres

Oligodendrocyte gene expression is downregulated in stress‐related neuropsychiatric disorders, including depression. In mice, chronic social stress (CSS) leads to depression‐relevant changes in brain and emotional behavior, and the present study shows the involvement of oligodendrocytes in this model. In C57BL/6 (BL/6) mice, …

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Early intervention in the management of pulmonary arterial hypertension: clinical and economic outcomes

Charles D. Burger, M. Saïd Ghandour, Divya Padmanabhan Menon, Haytham Helmi et autres

Pulmonary arterial hypertension (PAH) has a high morbidity rate and is fatal if left untreated. Increasing evidence supports early intervention, possibly with initial combination therapy. PAH-specific pharmaceuticals, however, are expensive and may have serious adverse effects, particularly when used in combination. The …

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HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

Crystal R. Leibrand, Jason J. Paris, M. Saïd Ghandour, Pamela E. Knapp et autres

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Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin

Bartosz Bielecki, Claudia Mattern, Abdel Mouman Ghoumari, Sumaira Javaid et autres

Significance Myelin allows the rapid conduction of electrical signals and provides axons with metabolic support. It appeared relatively late in evolution in hinge-jawed vertebrates and concomitantly with the emergence of the androgen receptor (AR), hinting at a specific role for androgens in …

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Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments

Fumio Yoshikawa, Yumi Sato, Koujiro Tohyama, Takumi Akagi et autres

Opalin, a central nervous system-specific myelin protein phylogenetically unique to mammals, has been suggested to play a role in mammalian-specific myelin. To elucidate the role of Opalin in mammalian myelin, we disrupted the Opalin gene in mice and analyzed the impacts on …

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Human Neural Cells Transiently Express Reelin during Olfactory Placode Development

Maria Cristina Antal, Brigitte Samama, M. Saïd Ghandour, Nelly Boehm

Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main and accessory, …

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The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

Rashad Hussain, Abdel Mouman Ghoumari, Bartosz Bielecki, Jérôme Steibel et autres

Myelin regeneration is a major therapeutic goal in demyelinating diseases, and the failure to remyelinate rapidly has profound consequences for the health of axons and for brain function. However, there is no efficient treatment for stimulating myelin repair, and current therapies are …

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The Brown Norway opticospinal model of demyelination: Does it mimic multiple sclerosis or neuromyelitis optica?

Nicolas Collongues, Jean‐Baptiste Chanson, Frédéric Blanc, Jérôme Steibel et autres

Opticospinal demyelinating diseases in humans are mostly characterized by the opticospinal form of multiple sclerosis (MS) and neuromyelitis optica (NMO). Increasing attention has recently focused on astrocyte markers, aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) in these diseases. We induced opticospinal …

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Detection ofN‐acetyl methionine in human and murine brain and neuronal and glial derived cell lines

Tara M. Smith, M. Saïd Ghandour, Paul L. Wood

Despite the fact that N-acetyl methionine (NAM) supplementation has long been reported as a bioavailable source of methionine in humans, and known to reduce liver toxicity after acetaminophen overdose, its cellular endogenous presence has never been investigated. We demonstrate for the first …

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