Abdel Mouman Ghoumari

Steroid-dependent regulation of central nervous system remyelination: From gonadal hormones to chemokine signaling

Abdel Mouman Ghoumari, Michaël Schumacher

Efficient remyelination in the adult central nervous system remains limited and poorly understood. Recent experimental studies reveal that gonadal steroid hormones are essential regulators of myelin repair and that cooperation between androgen receptor (AR) and CXCR4 chemokine receptor signaling in astrocytes controls …

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Estradiol Promotes Myelin Repair in the Spinal Cord of Female Mice in a CXCR4 Chemokine Receptor-Independent Manner

Marianne Bardy-Lagarde, Narimène Asbelaoui, Michaël Schumacher, Abdel Mouman Ghoumari

In the adult central nervous system (CNS), myelin regeneration primarily occurs through the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes. In men, declining testosterone levels accelerate the progression of multiple sclerosis (MS), while in women, menopause worsens MS-related disability. We previously …

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Crosstalk between androgen signaling and the chemokine receptor CXCR4: a novel strategy to promote myelin regeneration

Marianne Bardy-Lagarde, Narimène Asbelaoui, Abdel Mouman Ghoumari

Multiple sclerosis (MS) is the most common chronic disease of the central nervous system (CNS) in young adults and represents the first cause of severe handicap, originally non-traumatic (Oh et al., 2018). MS is characterized by the infiltration of auto reactive lymphocytes …

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Interplay between androgen and CXCR4 chemokine signaling in myelin repair

Narimène Asbelaoui, Charly Abi‐Ghanem, Géraldine Schlecht‐Louf, Hania Oukil et autres

In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating disorder. Testosterone has been shown to promote myelin repair. Here, we demonstrate that the cooperation between testosterone and CXCR4 signaling …

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Testosterone and Myelin Regeneration in the Central Nervous System

Michaël Schumacher, Abdel Mouman Ghoumari, Claudia Mattern, Pierre F Bougneres et autres

Testosterone acts on the brain and spinal cord as an important regulator of neural functions, either by binding to the androgen receptor (AR) or via its aromatization to estradiol. Neurons have long been considered as its primary cellular target, but testosterone also …

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Progesterone and fetal-neonatal neuroprotection

Michaël Schumacher, Philippe Lière, Abdel Mouman Ghoumari

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Roles of Progesterone, Testosterone and Their Nuclear Receptors in Central Nervous System Myelination and Remyelination

Abdel Mouman Ghoumari, Charly Abi Ghanem, Narimène Asbelaoui, Michaël Schumacher et autres

Progesterone and testosterone, beyond their roles as sex hormones, are neuroactive steroids, playing crucial regulatory functions within the nervous system. Among these, neuroprotection and myelin regeneration are important ones. The present review aims to discuss the stimulatory effects of progesterone and testosterone …

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Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture

Jennifer Rakotomamonjy, Abdel Mouman Ghoumari

Endogenous γ-aminobutyric acid (GABA)-dependent activity induces death of developing Purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. Here, using brain-derived neurotrophic factor (BDNF) heterozygous mice, we show that BDNF plays no role in immature Purkinje …

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Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor

Charly Abi Ghanem, Cindy Degerny, Rashad Hussain, Philippe Lière et autres

The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a late wave …

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Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin

Bartosz Bielecki, Claudia Mattern, Abdel Mouman Ghoumari, Sumaira Javaid et autres

Significance Myelin allows the rapid conduction of electrical signals and provides axons with metabolic support. It appeared relatively late in evolution in hinge-jawed vertebrates and concomitantly with the emergence of the androgen receptor (AR), hinting at a specific role for androgens in …

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Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum

Delphine Meffre, Ghjuvan’Ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski et autres

The identification of new pathways governing myelination provides innovative avenues for remyelination. Liver X receptors (LXRs) α and β are nuclear receptors activated by oxysterols that originated from the oxidation of cholesterol. They are crucial for cholesterol homeostasis, a major lipid constituent …

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Progesterone and nestorone promote myelin regeneration in chronic demyelinating lesions of corpus callosum and cerebral cortex

Martine El‐Etr, Marion Rame, Céline Boucher, Abdel Mouman Ghoumari et autres

Multiple Sclerosis affects mainly women and consists in intermittent or chronic damages to the myelin sheaths, focal inflammation, and axonal degeneration. Current therapies are limited to immunomodulators and antiinflammatory drugs, but there is no efficient treatment for stimulating the endogenous capacity of …

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